Pacific Northwest National Laboratory

Alzheimer's disease & dementia

The molecular mechanisms of Alzheimer's

Late-onset sporadic Alzheimer's disease (AD) accounts for about 99 percent of all cases, and is linked to multiple factors and pathogenetic mechanisms. One important contributor is a protein post-translational modification ...

Medical research

Profiling the gut microbiome proteins that modify bile

It turns out that bile is a lot more dynamic than you might think. One of the biggest factors affecting bile, which is very important to our ability to absorb nutrients, is our diet. But another is the make-up of the community ...

Medical research

Tackling infectious disease – one protein at a time

Garry Buchko and his colleagues are at the front line battling some of the most fearsome enemies that humanity has ever known: Tuberculosis. Pneumonia. Ebola. Plague. Botulism.

Medical research

Low-dose radiation impacts skin sensitivity

In experiments where human skin tissue samples were exposed to low doses of ionizing radiation, scientists at Pacific Northwest National Laboratory found that a skin tissue model showed perturbations that suggest its stability ...

Health

Man trumps dog: Earlier assumption about BPA exposure confirmed

Coating the mouth with BPA-containing food, like soup, does not lead to higher than expected levels of BPA in blood, a new study in Toxicology and Applied Pharmacology shows. The study authors conclude that oral exposure ...

Medical research

Are my muscular dystrophy drugs working?

People with muscular dystrophy could one day assess the effectiveness of their medication with the help of a smartphone-linked device, a new study in mice suggests. The study used a new method to process ultrasound imaging ...

Medical research

Study breathes understanding into plutonium-nitrate effects

A study led by Pacific Northwest National Laboratory (PNNL) scientists offers new insights into the retention of plutonium-nitrate in the lungs-as well as clues as to the cellular processes and structural changes that might ...

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