Sanford-Burnham Medical Research Institute

Medical research

How belly fat differs from thigh fat—and why it matters

Men tend to store fat in the abdominal area, but don't usually have much in the way of hips or thighs. Women, on the other hand, are more often pear-shaped—storing more fat on their hips and thighs than in the belly. Why ...

Medical research

Shifting the balance between good fat and bad fat

In many cases, obesity is caused by more than just overeating and a lack of exercise. Something in the body goes haywire, causing it to store more fat and burn less energy. But what is it? Researchers at Sanford-Burnham Medical ...

Medical research

Transplanted neural stem cells treat ALS in mouse model

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is untreatable and fatal. Nerve cells in the spinal cord die, eventually taking away a person's ability to move or even breathe. A consortium of ALS ...

Medical research

Making it easier to make stem cells

The process researchers use to generate induced pluripotent stem cells (iPSCs)—a special type of stem cell that can be made in the lab from any type of adult cell—is time consuming and inefficient. To speed things up, ...

Alzheimer's disease & dementia

Brain enzyme is double whammy for Alzheimer's disease

The underlying causes of Alzheimer's disease are not fully understood, but a good deal of evidence points to the accumulation of β-amyloid, a protein that's toxic to nerve cells. β-amyloid is formed by the activity ...

Medical research

Scientist models Smith-Lemli-Opitz syndrome in adult stem cells

Studies performed by a Sanford Research scientist using an innovative stem-cell model for a fatal developmental disorder is the focus of a recent study published in Nature Medicine. Kevin Francis, Ph.D. uncovered unique cellular ...

page 3 from 6