University of Bonn

Genetics

How nerve and vascular cells coordinate their growth

Nerve cells need a lot of energy and oxygen. They receive both through the blood. This is why nerve tissue is usually crisscrossed by a large number of blood vessels. But what prevents neurons and vascular cells from getting ...

Neuroscience

How neurons autonomously regulate their excitability

Nerve cells can regulate their sensitivity to incoming signals autonomously. A new study led by the University of Bonn has now discovered a mechanism that does just that. The German Center for Neurodegenerative Diseases and ...

Genetics

Mutation in TLR7 increases risk of severe COVID-19

Rare gene mutations can significantly increase the risk of severe COVID-19 disease. An international research team with significant contribution from the University of Bonn compared the genetic material of 5,085 people with ...

Neuroscience

Secret structure in the wiring diagram of the brain

In the brain, our perception arises from a complex interplay of neurons that are connected via synapses. But the number and strength of connections between certain types of neurons can vary. Researchers from the University ...

Ophthalmology

New diagnostic option for rare eye disease

An estimated 5 to 10% of blindness worldwide is caused by the rare inflammatory eye disease uveitis. Posterior uveitis in particular is often associated with severe disease progression and the need for immunosuppressive therapy. ...

Diseases, Conditions, Syndromes

COVID-19: New energy for flagging immune cells

In severe COVID-19 patients, metabolism produces insufficient amounts of certain energy-rich compounds called ketone bodies. However, these energy carriers are needed by two important cell types in the immune system in order ...

Overweight & Obesity

Molecule boosts fat burning

Normally, fat cells store energy. In brown fat cells, however, energy is dissipated as heat—brown fat thus serves as a biological heater. Most mammals therefore have this mechanism. In humans it keeps newborns warm; in ...

Medical research

'Growing end' of inflammation discovered

Redness, swelling and pain are signs of inflammation. It serves to protect the body from pathogens and foreign substances. Researchers from the Universities of Bonn and Cologne were able to show that inflammatory reactions ...

Neuroscience

Enzyme prevents brain activity from getting out of control

Our bodies have the ability to modify the contacts between neurons. Among other things, this is how it prevents brain activity from getting out of control. Researchers from the University Hospital Bonn, together with a team ...

Genetics

Hydrocephalus often caused by disrupted brain development

Hydrocephalus in children often has completely different causes than previously assumed. This is the conclusion of an international study. The researchers identified a series of mutations that cause disruption of early brain ...

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