Vanderbilt University

'Idling' cancer cells may return

About half of all melanomas have mutations in the BRAF gene that accelerate tumor cell growth and spread. While most patients benefit from targeted anti-BRAF therapy, resistance to treatment and tumor progression is almost ...

Apr 12, 2018
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Aqueous humor, microRNAs and glaucoma

Glaucoma—the leading cause of vision loss worldwide—includes a heterogeneous group of disorders. Primary open-angle glaucoma (POAG) and exfoliation glaucoma (XFG) are linked to decreased outflow of aqueous humor, which ...

Apr 11, 2018
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New view of the heartbeat

The human cardiac voltage-gated sodium channel (Nav1.5) plays a critical role in maintaining regular heartbeats. Mutations in Nav1.5 cause life-threatening heart rhythm disorders (arrhythmias).

Apr 09, 2018
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Lung diseases share molecular signature

The fibrotic lung diseases BPD (bronchopulmonary dysplasia) and IPF (idiopathic pulmonary fibrosis) affect preterm infants and older adults, respectively. Evidence suggests that these diseases involve dysregulation of lung ...

Apr 06, 2018
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Voluntary exercise and energy balance

Physical exercise alone generally fails to produce meaningful weight loss in obese individuals, and reduced non-exercise activity has been suggested to explain this observation.

Mar 23, 2018
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