%PDF-1.7 % 13 0 obj << /Type /Page /Parent 1 0 R /LastModified (D:20190619064743-04'00') /Resources 2 0 R /MediaBox [0.000000 0.000000 595.276000 841.890000] /CropBox [0.000000 0.000000 595.276000 841.890000] /BleedBox [0.000000 0.000000 595.276000 841.890000] /TrimBox [0.000000 0.000000 595.276000 841.890000] /ArtBox [0.000000 0.000000 595.276000 841.890000] /Contents 14 0 R /Rotate 0 /Group << /Type /Group /S /Transparency /CS /DeviceRGB >> /Annots [ 6 0 R ] /PZ 1 >> endobj 14 0 obj <> stream x[]o6ϯ z pTQzfmWCXmDl$%){}lI,ViM԰#[9!iّw~9y!KIx H'kgiIjO=Oș<  ȢEO7,ZHu|n&Q2+R'4H &~R(T$:"+~'/m~*"c`4i5o9vcdܘ tl~PoM}̒ -3QL^͞D!->"^~2,'iϗE]y9yseSP&+2ybb+BDh6wA{,ːRTE4)sAB#|L"<$@]3?рHQv -o/|2 nxp˕ISj9Vy߲Tk +4{%ia5< Oycrɻxr8Lp'o".d+_"HyD^1Y5h5MU!ϥ~ճ}wu$siʙp(R:m$da;-k8i%@>ڮG^+kސTĬ9ZajQO^F/ j4rd~@$ߊw ű-8]3( Qjh/Dv`6L9k' f趲BO-9 |h/ÓGHՠƂF*NȽћuo4w{ꃸ,!iUmPz2ǀg̻ؓ7vMH5!LcG8gQ-Z`(L N;Dճ䌣@w XgzHWU0E > s &TC@dI _f t.ũ6W_-(za۴pT\ΐ1xԲƐ=';]0V^k_:ՉcVv&RI%:V"a hZaG*nѹmtYJ6@k9C+ m6)ۉJ828dJ@Ge,̳G\@Xr{2C(Y5*J:;lq*3(#1Dэܹ+\" ??h|}tFߛt9iI 9Onț~} AhQaYOPģ#_??f endstream endobj 15 0 obj << /Type /Page /Parent 1 0 R /LastModified (D:20190619064743-04'00') /Resources 2 0 R /MediaBox [0.000000 0.000000 595.276000 841.890000] /CropBox [0.000000 0.000000 595.276000 841.890000] /BleedBox [0.000000 0.000000 595.276000 841.890000] /TrimBox [0.000000 0.000000 595.276000 841.890000] /ArtBox [0.000000 0.000000 595.276000 841.890000] /Contents 16 0 R /Rotate 0 /Group << /Type /Group /S /Transparency /CS /DeviceRGB >> /Annots [ 7 0 R 9 0 R ] /PZ 1 >> endobj 16 0 obj <> stream x\]o}X嶀CS$[&-"M $@ۇ6&.iE!߽3;K4MD\-[93shKR>؎ Wd-4N7WqZGWgON1<On?./Jd>|}O;ڇ/_;P>k/ /+wK|%,Mb/"cW%+ޔLlEJi.6 \Wo7Ұ=||⟦bIcFgZlng+MLW˜UW1޶޶/+l̨ Sχ@>\Yl;jnTi\Vo.!E1}hAE4 hVCjZҴŏY*Qt\8&suG\VөNނ&sS7J6DӘ"8f#+1j;JD3 :Lntgk~)N"b,;($NSpVFAXZܵ4Wpv @7Ih_ SNػ6s" 8S2&q(`t.%@z6=[_F8kz)4-mr6jTYA:&<9jbЊ wtj% jY`|[L`DTP51z۪n#>&wDSKKۍmkk\y!9!i +b(ķCBb5?ʵĊj&;oaIG@l[ KaA.g?t%]lE:Ctt [Vqܒ"6YKx9ZŒN]z1`t Kl8"ߧvr:0$=-AZ|Ì%ӢdoR`{U+#ǍPf ”H%piˑG%LP„(%#O#FxC2}X1Hh/+i6ȈWp!FH'q ]3WSQ'|_H`D,Az=as]xk1=NpnZf` f9Q_ਯ_? P4p/% ak*e2h)?'G ãOs¹$@N\L:[[Sh,CY%NKs "" B_k ]`5 Q3M|e 7}!a;82zq׷A1}>a2"" KQ.=4ả CG^2#׍\ɂ.|xRkYLaFd~VK8g4űNY"BF4ZT [Z?BюVPX|Aid]y1'\k\D_3GݽOB+in.:t@-E#V}3}tT|ck% Y" #g@ r.$}lH}٨dItl<MRKO8"5*<8SЭZ/1#\k`nYb1}t /;MkI ;2}mcl +r̈́]d!ʑer AZJiZx c--. ]Ue8 gp̒khC[,蘲GhiwGVN+;aaRK^:ZE‘7Ϲa^d7#% f%H :A,EeCs8!QbAwYWFDD >YǑN]S6>}kd>` ּ\p kZp{1#5VjܗWWSUܝeS:4dH;)7T#-D=]0ái,qzw07@Bۯ!ޱh9h[v֝Lv$9Q;kԶYٛ?;wgԒyvi{!s/ϓۀKb!|3 O[i>}dv-.w[_YWx_.VYQOYحgE5B =Y?`̿ {*h>hz{"7lCΦ[[}?b;nxG*p P_ƒ{rjt7Ln" 2/%*7済5t7ȫV-o55w*8ѿx|M؋1kp~×[Q]/_~7E7ͤ1n˪Ovm^_kyY*yN>dGA$GQx|Al/2/^UE_~&Zъs(=G={ƍ(mj^o|"uu٭&w> /Annots [ 10 0 R 11 0 R 12 0 R ] /PZ 1 >> endobj 18 0 obj <> stream xVKo0 W"˖u} (6 |J¶\Y?NҴͣkl HDR@p{)PxwW\1}emFpfҐ4|ܬXnALު|!{_ ?[B;1]p;^w۔0 {!~߮m avmngY;6g>|z Jlp48o2FHJenF|`, wʪQ fR< fyiT^,F"*w]7Q_ q1]$$1j'p=f1b4I!rgߜ񀄜#ebLYHeg]DBUa̢uc-Yy咅KĥNHyfmb>է{HJf5cZ <[ҵ#m]ؾK큭]Mn-;`}ű6N{ѵB:!p U4W0 UδO 2֦(RgHi0TM,| E3Mgz,drZb-k *&ji&jjZƈJsٶyU9?h$Sk`ï@ٌ,A>?VWYHdk'-򁪅Ɛg.`xT51I2ow.q|/k.v՞}xa>cq\[sUq=>'}NmD842\ɒ?* endstream endobj 1 0 obj << /Type /Pages /Kids [ 13 0 R 15 0 R 17 0 R ] /Count 3 >> endobj 3 0 obj <> endobj 5 0 obj <> endobj 8 0 obj <> endobj 19 0 obj <> stream JFIFHHExifMM* z(1>?QQ Q HHPaint.NET v3.5.10z%u0`:oCC." }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?(f 1T$`9Sw(B@;~(]Cd꾫Es:aݻd2\(2F][&]ۢϲ|W͵L@A A 8 (CĝCglZE/ |Ezє{ xQʒ@[ྊ\/I4R0?6.7`ŴwPu|3/Z@Ogi}cFdFKoj?~8|p_A<ĺOkGPK $wRmkmF;YVx&rLj#p ׭axf|s$Ӿc:Qwm]N)Cψ[eYba98xB+oTÚwcRþ$U[ ?qΙ{&jv6Xo$=ԗ&7zgAxIִ.$3,mwc{+%g[!U@&Fϻm/#hci'7n[%It.&/ֶ+Zl~:wi~D>$}o+}@.[/+B6mnt8bi{zc.~F{eUe86g3 VT&> BK VؘXzSMesoM_&ϔIÍK?+hڿnt_ K]H '̽yrWA=O+|"!gɤItXe>Xs hwwG Eouqa /ş_~~'x} ]_^]/ 蚼:<cu/ h&omEۯicǪ\[,k}_uS}㏆W]G^tmf`Ks ]=va&h9n忔>75NWQτ0of,E (˰8hBC_ Jq'W UQKz,N>+`S%}b5ISJ]+(&QVN>eoy7xG4[]]3K{i$I>g-(mbynLIC,"*3f?-%`lfPx涽X"H'h"ֈ(TfeU:܉,a,R*I4xcxalOhGр|ia$cg,{gAHEu->]F,{-.,EX"I$XQD/3R.{{T&ҭ%4[OPnx"HhM :e}-Լ'=s:\iZ<+Lj5+1AɮLZx-☽G3 1I"kuχ+A}5'NxI8 gJk[oenm!x,=n=>}kjPx~M񧍼5k45a,RLiȖTFQMR&K;}r+XkY[y>2F=2~6>Gmi++<[WF76MH4>;;Kf۽ъM3ZE}c㿈*- -.|G5uI![ YR$$A>Eyׇ|7u;n>4׭JϷR[h!rVr\{~Ϛ >0jMg?_y_ Do/x;ÚƏi a𶕦f|Eqgk4V^RY]}F,/J%ՌAud%:x3Hg_4[+^ ҴKaXF'n.]Z(i$bef5GO:u]/a~.3N4xiG*a8ާ-U){G nJEڿ[m7wv5MYp|'gm # #%B?|鿲w­{+_|Q#VkxcZޛ{I]Wyak}..i˨iY9QwOA~hf{+ |Y;cڴ27G>|H,na8o; CEO,ZLP?SHK} e92W7/1aj¤aڄq4 қS7,5]%EƔc/uҒw\r/EnT y>!V+VK4X^Y{;+Ӫ=MqslEn?Zz'Ë}^2xĺGf70/M~*DU=坍G{wwvci%vZ$GY&J9dkՀ\6hs.F*ĩ"+S%s*{ qqDj3$ q^T24,Cn +=j񟍼q5k'\%ݎ{ͦuyq4X$y<ك2Ey%™|Icw]3#R[`{KցY [1*kLOdw ^OAkЏb<¿ <=6x0ׄ>(=*[ t]9-?IZ@}/>FۃQ@ endstream endobj 20 0 obj <> stream JFIFHHC     HoZ_GS/RWr#>`['Suggmh>sVlIT=Jw|dlfޜ9J.ՒgGiKqV|n~-s78i\mc턱ETxyx z+Sh,suMj 8j篎3,O}:x"@-A1 !P"01@#2345AB`6ƪ":2u>AUS42't71S'c&.} JH%'Jq8>D\h2`܏ B=KB`CZį#d 8 :,x+>=Oi81] HOuo@gNIV݃ *G)Z5P` <: '# Ѯgw1o$,F;k- C,|R0z1uFm);1{RIKHzxLVEN)j~m9>L " \pN̹ZFP&>'NKA*73*7 *9I2(+ܕh hkq?揔 Xd&F6^*ʹqr.۴|cOa|Lҹ#n~VDNRE@IS /G4D'7B;Y Lٙ%V[?6[m@%;uc +tr5pзo?NU-y~]!h"Dr 9׀́t2 |V[%Q/96-ǧC'l`oxOЊVM1sԓ0cTq&K dJYƗ$)|T{` eyb'PKOQ4%5+qE3&%2k8,H]9튉r}/~uҨ$VS0ʫ+M(ze"9?2X?n8Q_%|d>T 2n;y06|!=^".Dd)2z ~ikf_͌Mjr'K!*OTH:~8|I?ڒo)с#)I8Ρ>RRjrZHn 8!qf26NW,li9-fLכ^ B6-V|QhkdӄV#`qG|zΧwKU5dq%R4==UBHom*XWCM%H.Hms,BO* rEg5:?dZW$ O)F<޴bGxM$+xo?9j"Uj}s?9G'Q&THQŪ3Xe+><3XCs{i[̏d :YUId1{&} n͍+;:c䢻,F*JLibù#5m)Y:ur nO,WXh*-#|I#ݞZy >N".Ov0&Ҕe);CAAᴙIZ[~fmBQZ$Tn҄c@leN.OjyGaGbIflt2Ĝ4$:Gd'9ʔ.yDb!>E=:(k\p B~=0,'.^pO!FY3I8Z2'ie1LFXxz/w{V{,kJE p5d~ػ0ƕ܏Ls~5qkhiJUPԵ>A?̍Q{|lZ[+X[vhR-f#Pt}C:LΗ~UsӤurW߬DF,'/Hw[Я?M=3?N?ntv]KX.b_5Z)q)v}r= jjw?ks]w/t}> !1 "0P@Aa4Q`q#2br$Ss?—^KYj\JY/^uX&WL([0O)aF)~ :~%e}K&ej_1Y]0eB2l[1QVWќ&4)uzMѲ>,' ]2xyU-ȶ/8'>i^BJ(8AAbOa,W)8M076 xr >j[}XVvOk&P7-h;5K]Y6'WVYz'MKQ= &)& iqL6:p#yQEG)Bp*ۑzY]i`Psلˉj °MODrڭG pˬ }ԹE4*z=2$luDն 3:fO\,S:k6(c3…:dN \!3e8|кet4;tەe$]OV2*,-+J(ħLi*GCvL<".-BvΣ-ÉR]hWE7qS8g5fa NJXq6_u`2Lzj8Qf c4D:I ~#CQD& 31NY\dJzeU[Fԭ`"$}./D&\O2&*[QhܧL|M*Yjn.u"6AhI!6T;$.d5!&`oSHcq_"oSe!lQCF #*$O rkS)n1,P9C'A2D9/QW/cJCTRc-K3Zair5C .A߉ZM u㯥M.R,|rK zQLa 74.cJ°JyB^c6,~Ƥb\A;VLJeKRBJBlFT LSy% f'Ska]B`jYhf yCG(DQ: l0f0Eڈ[',CUq U1XeA3*g VL)Ə~&O r@WX(\0LOkܯ&P:' 0TS~#:pE8e&3yq(7*UTc*"7HCFaTc%a2Q* NeAaa1nH_/RpjK7 KWC,VZc0GLRp%{Q+BZnOM^2G`G=IMu2LlV<" pQd,+idc{e5C@fhH,Xܹs 0jUG32p'rg N¬i_°H¥1OpHp9Ե<; Cj*s/=JP+!)ʾeQ<QW蛔(! ̗Ŀ8fV;fc\03:iSbzO2^|@]N1)yyj5c@kK0 "Q~htj)06.]"(ͰJ7>(/öN~P*kQst` wOk~(YT+ōE t yT|~ֈuW6"ˊ)R+,u)| nksK|n@.6#9])ڀ{<ėldzf 51V9vܣNN~>j[G1g=lbL%CLᗱŠu׽.,Cj-U=_Muo<%wc'?&:#Sos, !1AQaq 0@P`p?ƞJF ]Ws6Ϥy` q̢qQUiJƥ&l-b~Q4UT&f[FEWw/ H5Q?%G,(7DU[ʗ^bvZi _Yq`mOdjs|J} n/@˖quqxM=LQ4'54 a&dj|ʜ *f 'X/LrGwQRy3(pjZ:cO"u)Аjh[*:+U7h1&ܱP50C)@,`ՁKx P89^u0s.F =&#~=jrW;X6 h=fj,Q̮ʪaЮ}"Ʃ/׬mX%i+|fP­1m~f[!NaUE*RT;{6W1^SK:җff.eHֱf Z"cIKx~=GyiʜD/O1%br˂K|59(>]WN"UHָl ɷZ}nqj&lpU\i L)vI*"º|D%5{2;7;+>&Մؤ@/k7\JuxAz%Qƣ9iRӄm\ofsQ ⲢԅDݺx Co 3+CAA]CpKšq*e;.͐).ߦ ([mt1\`C@fvc0CʴwAzϬkcBph/\^NO$qMݠ}\6^{n ӽJ *z8?׮2\ *wz*YDnm 5c ܬ zlՂN }㡋!U02߄9g/cQ hsImU+p*R?_0nAWLqHtn8UsLk?t߫/poJjŦM+ksޘ+ -z !.Ϗ6u/)59fj VN(pB5ĭk3ԯqX6zbK(h㗉^nSJBajdk̴ikuL\n.('Ͷg vULkwdF+Q`0-kn-\^K]@ }‰(.NOi4ގqUsyKbq,9Sybg'q*m{ aǬ׼sTQ(#:T6 &5^aF0-Ņ'_;j}K*Tg+I9b%LR;TO;XEU\M:pDWAȹPE;y߾"iR+mN`GbNg3j}˛~ (_oucO#n&88\F8$պ֛XpL;%f)$#mI]s5nZPj *Dj劜T?eQa CTWWr0h. bψj"H egp" }VfaK|&#wi9N(ܤzuxe~+Jp}FEDUfUހ/(xP5y Ӹ֙LP*G+# o05 W)!(`?Y/F f6!FhG5"v/)#UejG)B0*vAD2VbrVO?6x2(q5i*tjiB-9#2+3w39nP;F%]9?D &ɖ3m^,[ L^@ʱBáP:"'"SN1R Z50: SO3B;Poa7p */ڜQlˬ(PytR`ƹ*]6(@<;F/*W\ڔf6ϼ;pFdxs;6~&Y|ОSB*oݮeWKɪcs00!yԽƸ*e/A}j'ur*|0UÐl !ww6E;VqQow [NT1@o8M(# EUW>ҭvGscJbpJf,YXEʿ9\=* >DwWh Av, ,G \W2w9Ʀb٣`ߘoǙC$At+.9ڭ c#\4L=c.z1zD)3!V7BO#to}T*lZq B|bƸXյb>ߖ6 g,T[Fz#C&(o6r\7C`P?0 F;EnaK+i#VIK繗"-bDwlNrO4K/f1W2}5-Ffo@FͬF9Fye^MUڡiϼLɃDm9\4~OP VfB?3L%,ZznӔ [Lc TVVY 3uh$hsjD F-ߟ# E%fo G#<1T+bZ2V0K1_?^o&!5N(dprq|%z x2 ,WcXɁR:9|Wg?bj)dN{ai_^&jAT<}!ں,peS?nŨKvL6ܪ}]Lʗ2]}l8/58"s z_FI' 8jI[ |ͱ2ܻݘex$sM->+O! /)  J oJܿh1ߋ!6sG2]_Y m(Ri2ɞc X%"\&k +Gèo1w EuķZ cp7GHnb׸bt&1+~؍ F6QˌG\ˆXeݧ1 ]fDnwSQ90îu 7.ܶQ1+Yk2](s93gڦ42ϒ(︕4U2 l0(A pc]f;!7Qqc9dV<.l%vK\μg{XZ6EY1+Kjޫ{%Y<_5 Ǎj]3{k}ƪ>ߠ}KR(9xnsS`ٮ>eXܕ|c>{1aa`&2F34x{y_T%R|tc̲Z=8`p=fD3f7ƢС7U4g@CFy»oJ~p,壈5ez5^bvqx2p=l(:ݘ7+*FWbQqS*g3 kzF k߉rC/&bH6|bESB\6ҥA^UX_xfs^(A|jiT%ʼn‰Stvg2@lbVe31BD][-@R-o5ܼ҆9D5tŭ{N?8#yJL56ĉ[K'j*iTAw*}l@h2ʊDxrPEt*@ +g9?zhZft\q3UZJړ8VOIn5Vn<%Pܶ7OHQv^,n 5y37-LT]砕8SϴA/Bld+Ye"-dcٮ.6E(hBZN#_$ 9Ra3VSnP`Z& 0!ϖjZ"`*f:IJBT̬@9 lC52bpqQ4[Υx¦qNe6 )&MG"n"Re.rzj/ @gqiQG1p @5Jk%Zk5F2Ts׳Xo!Z[R-⚊RB!#cQH U,P5M$jk*"D)f.dxskY?qQif5BeƋTU|D0?2"C׶Dr3AJ endstream endobj 4 0 obj << /Type /XObject /Subtype /Form /FormType 1 /Filter /FlateDecode /BBox [0.000000 0.000000 595.276000 76.535433] /Matrix [1 0 0 1 0 0] /Resources << /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] /Font << /F2 5 0 R /F1 3 0 R >> /XObject << /I0 19 0 R >> >> /Length 197 >> stream xKkBA WeI&ڊU/ nʥBf8A3!(X4`JQj*Aj͕197f hkL[=µrw]F D%x2WC0 9)Z ^Wh}29yyu?4g=bT1߻a endstream endobj 2 0 obj << /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] /Font << /F1 3 0 R /F2 5 0 R /F3 8 0 R >> /XObject << /XT4 4 0 R /I0 19 0 R /I1 20 0 R >> >> endobj 6 0 obj <> /H /I>> endobj 7 0 obj <> /H /I>> endobj 9 0 obj <> /H /I>> endobj 10 0 obj <> /H /I>> endobj 11 0 obj <> /H /I>> endobj 12 0 obj <> /H /I>> endobj 21 0 obj << /Title (Limited restoration of MECP2 gene expression may relieve symptoms in Rett syndrome) /Subject (Limited restoration of MECP2 gene expression may relieve symptoms in Rett syndrome) /Creator (Science X Network) /Producer (TCPDF 6.2.25 \(http://www.tcpdf.org\)) /CreationDate (D:20190619064743-04'00') /ModDate (D:20190619064743-04'00') /Trapped /False >> endobj 22 0 obj << /Type /Metadata /Subtype /XML /Length 4405 >> stream application/pdf Limited restoration of MECP2 gene expression may relieve symptoms in Rett syndrome Limited restoration of MECP2 gene expression may relieve symptoms in Rett syndrome 2019-06-19T06:47:43-04:00 Science X Network 2019-06-19T06:47:43-04:00 2019-06-19T06:47:43-04:00 TCPDF 6.2.25 (http://www.tcpdf.org) uuid:a925466a-1b65-dc2c-ddbc-46c69ae89f16 uuid:a925466a-1b65-dc2c-ddbc-46c69ae89f16 http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text endstream endobj 23 0 obj << /Type /Catalog /Version /1.7 /Pages 1 0 R /Names << >> /ViewerPreferences << /Direction /L2R >> /PageLayout /SinglePage /PageMode /UseNone /OpenAction [13 0 R /FitH null] /Metadata 22 0 R >> endobj xref 0 24 0000000000 65535 f 0000008016 00000 n 0000028862 00000 n 0000008090 00000 n 0000028361 00000 n 0000008196 00000 n 0000029019 00000 n 0000029263 00000 n 0000008307 00000 n 0000029504 00000 n 0000029759 00000 n 0000030043 00000 n 0000030326 00000 n 0000000015 00000 n 0000000485 00000 n 0000003034 00000 n 0000003510 00000 n 0000006682 00000 n 0000007167 00000 n 0000008421 00000 n 0000014057 00000 n 0000030544 00000 n 0000031146 00000 n 0000035634 00000 n trailer << /Size 24 /Root 23 0 R /Info 21 0 R /ID [ ] >> startxref 35844 %%EOF