https://medicalxpress.com/medications-news/ en-us Latest medical news and research in Clinical pharmacology Pancreatic cancer is one of the deadliest cancers and the third-leading cause of cancer-related death in the United States. While scientists continue searching for new therapies, advances can also come from understanding how existing drugs work. By uncovering the underlying biology, researchers can identify new ways to use existing drugs, improve their effectiveness and overcome barriers that have limited their clinical impact. https://medicalxpress.com/news/2026-06-foundational-therapeutic-strategies-emerging-cancer.html Tue, 23 Jun 2026 16:40:01 EDT news701446036 Many conditions that cause vision loss share a common feature: the gradual breakdown of the retina, the light-sensing tissue at the back of the eye. Although scientists know some of the structural changes that ensue as this damage progresses, less is understood about the molecular signals that shape how the retina copes with disease. https://medicalxpress.com/news/2026-06-erucamide-molecule-eye-response-retinal.html Mon, 22 Jun 2026 19:40:06 EDT news701360308 Our body loves the state of homeostasis, where everything is in perfect equilibrium, from temperature to pH levels to fluid balance. As soon as the body's core temperature drops below 95°F (35°C) and stays there for a long time, the heart, nervous system and other organs start to function poorly, which makes hypothermia extremely dangerous when not dealt with immediately. It is a medical emergency that can result in loss of consciousness or death. https://medicalxpress.com/news/2026-06-hibernation-cooling-brain.html Fri, 19 Jun 2026 15:20:02 EDT news701082772 A new gene therapy has been used to successfully treat a deadly childhood liver disease in mice that model the disease, according to researchers at UCL and Great Ormond Street Hospital. Arthrogryposis, renal dysfunction and cholestasis (ARC) syndrome is a lethal genetic disorder usually caused by a lack of the VPS33B protein, with children diagnosed with the condition rarely living beyond their first year of life. https://medicalxpress.com/news/2026-06-gene-therapy-arc-syndrome-deadly.html Fri, 19 Jun 2026 05:00:01 EDT news701013761 People with obesity and type 2 diabetes are at high risk of blood vessel damage. This risk depends not only on the genes a person carries, but also on how they are "read." By changing the epigenetic reading signals in the thin fat layer surrounding arteries and veins, researchers led by the University of Zurich were able to reduce inflammation and improve blood vessel health in both mice and human tissue. https://medicalxpress.com/news/2026-06-epigenetic-drugs-blood-vessels-obesity.html Thu, 18 Jun 2026 15:50:01 EDT news701015342 A new kind of flu vaccine moved a step closer to the U.S. market Thursday as federal health advisers recommended approval of the first made with the same mRNA technology that was key to ending the COVID-19 pandemic. https://medicalxpress.com/news/2026-06-fda-panel-kind-flu-vaccine.html Thu, 18 Jun 2026 14:46:14 EDT news701012712 Metabolic dysfunction-associated steatohepatitis (MASH), primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are progressive chronic liver diseases linked to abnormal bile acid metabolism. Although these diseases differ in origin, they all lead to a similar outcome: abnormal hepatic accumulation of bile acids and liver injury. https://medicalxpress.com/news/2026-06-rhythmic-drug-dosing-boost-safety.html Thu, 18 Jun 2026 11:40:07 EDT news700998163 An international clinical trial has identified the optimal antibiotics for golden staph bloodstream infections, a breakthrough set to reshape treatment for the life-threatening condition. The SNAP Trial found that the standard antibiotic, flucloxacillin, should no longer be the drug of choice for treating the infection, revealing that cefazolin and benzylpenicillin offer safer and equally effective alternatives for patients. https://medicalxpress.com/news/2026-06-global-clinical-trial-reveals-safest.html Thu, 18 Jun 2026 10:20:06 EDT news700995168 With tens of millions of annual cases, gonorrhea is the second most frequently reported sexually transmitted infection (STI). In the U.S. alone, more than 600,000 cases are reported each year. If left untreated, gonorrhea can result in severe reproductive health issues, including infertility in both women and men and pelvic inflammatory disease. The infection also increases the risk of HIV transmission, and—if the pathogen spreads from the genitals or throat to other parts of the body—it can damage the heart and cause meningitis and sepsis. https://medicalxpress.com/news/2026-06-ai-screens-million-compounds-uncover.html Thu, 18 Jun 2026 08:40:06 EDT news700988701 Removing criminal penalties for possessing cannabis for personal use, or introducing tightly controlled legalization of cannabis, does not appear to increase levels of cannabis use. However, the commercial sale of cannabis is linked to increased health risks, with large-scale for-profit markets—such as those seen in the U.S. and Canada—resulting in more potent products and higher rates of addiction. https://medicalxpress.com/news/2026-06-legalizing-cannabis-addiction-tightly.html Wed, 17 Jun 2026 18:30:08 EDT news700904521 University of Guelph research published in the journal publication Blood has uncovered a surprising weakness in acute myeloid leukemia (AML) that a compound in a common skin care ingredient may be able to target. https://medicalxpress.com/news/2026-06-inhibiting-high-leukemia-abcd1-protein.html Wed, 17 Jun 2026 18:00:06 EDT news700931546 A comprehensive analysis of 173,303 genomes from Pakistan, published today in Nature, is upending how scientists understand human genetics and drug development. By identifying 34,000 people who are "human knockouts," with complete loss of function of at least one gene, the study reveals variation in the human genome needed to shape new treatments for human diseases while also illuminating why drugs developed in mice often fail in humans. https://medicalxpress.com/news/2026-06-pakistani-genomes-reveal-knockouts-mouse.html Wed, 17 Jun 2026 15:40:05 EDT news700921554 A drug previously developed at UCLA to help heart tissue repair itself after a heart attack might also help kidney tissue repair and regenerate, researchers have found. https://medicalxpress.com/news/2026-06-kidney-protein-blockade-scarring-faster.html Tue, 16 Jun 2026 16:00:01 EDT news700843681 Cancer cells are remarkably good at adapting to stress. When treatments damage them, they often find new ways to survive, fueling drug resistance and disease progression. https://medicalxpress.com/news/2026-06-hidden-pim1-pathway-prostate-cancer.html Tue, 16 Jun 2026 15:20:03 EDT news700838188