https://medicalxpress.com/ en-us provides the latest news from Cincinnati Children's Hospital Medical Center Researchers at Cincinnati Children's, working with collaborators at University College London and Oak Ridge National Laboratory, have identified a practical, data-centered strategy to reduce bias in artificial intelligence (AI) systems used in children's mental health care. The findings, published in Communications Medicine, address growing concern that AI tools designed to assist clinicians may not perform equally well across patient groups. https://medicalxpress.com/news/2026-04-method-advances-efforts-bias-ai.html Wed, 15 Apr 2026 16:40:01 EDT news695486823 Scientists at Cincinnati Children's have identified how certain immune cells are molecularly programmed to respond faster when the body encounters a familiar threat, shedding light on immune memory and its links to diseases such as asthma, multiple sclerosis and inflammatory bowel disease. The study, published in Cell Reports, found that "memory" CD4⁺ T cells—immune cells formed after infection or vaccination—have their DNA primed to activate key defense genes within hours. In contrast, naïve T cells encountering a pathogen for the first time can take days to mount a response. https://medicalxpress.com/news/2026-03-cell-reveals-immune-memory-cells.html Thu, 26 Mar 2026 18:20:03 EDT news693762781 As modern medicine leaps forward in its ability to quickly and more affordably run genetic disease risk tests, ethical questions have swirled about how best to inform people about risk findings they may have had no idea were coming. https://medicalxpress.com/news/2026-03-medical-centers-highlight-responsible-ways.html Mon, 23 Mar 2026 11:00:09 EDT news693467686 A multi-center study led by researchers at Cincinnati Children's sheds new light on why some newborns become severely ill from Escherichia coli infection, but others do not. It turns out that most babies are immune because of germ-fighting antibodies they receive from their moms. https://medicalxpress.com/news/2026-03-mothers-exposure-microbes-newborn-babies.html Wed, 11 Mar 2026 12:00:10 EDT news692362452 For many people diagnosed with cancer, treatment with immune checkpoint inhibitors (ICIs) has dramatically extended lives. Some of these treatments, such as Keytruda and Opdivo, have become familiar brand names. However, for some patients, ICI cancer treatment can also prompt the immune system to attack heart tissue—a potentially lethal side effect. https://medicalxpress.com/news/2026-02-discovery-immune-checkpoint-inhibitor-safety.html Fri, 20 Feb 2026 12:20:02 EST news690812164 Experts at Cincinnati Children's have uncovered striking metabolic differences in people with Fanconi anemia (FA), a rare genetic disorder that causes bone marrow failure and dramatically increases cancer risk. https://medicalxpress.com/news/2025-11-metabolism-fanconi-anemia-rare-genetic.html Fri, 28 Nov 2025 14:00:07 EST news683374048 At the cellular level, the mechanics of how muscle tissue repair occurs gets complicated. There are significant differences between, say, tearing a muscle in a sports injury versus muscle tissue wasting away from diseases like muscular dystrophy. https://medicalxpress.com/news/2025-11-macrophages-neurons-faster-muscle-injury.html Fri, 21 Nov 2025 11:00:01 EST news682876331 Immune checkpoint inhibitors (ICIs) emerged in the US about 15 years ago as an exciting class of cancer treatments that have achieved complete and durable remissions for thousands of people with end-stage metastatic cancers. However, many other patients have tumors that remain "cold" and unresponsive to these treatments. https://medicalxpress.com/news/2025-10-mutation-yields-hot-clues-immune.html Wed, 29 Oct 2025 16:50:03 EDT news680973447 One huge reason why the world of medicine hasn't yet found "the cure" for hard-to-treat malignancies like acute myeloid leukemia (AML) and many other forms of cancer is that the world of science is still striving to fully understand how our bone marrow forms the many types of cells within the stuff we call "blood." https://medicalxpress.com/news/2025-10-rethinking-bone-marrow-framework.html Wed, 22 Oct 2025 13:31:05 EDT news680358661 The technique sounds so outlandish that it won an IgNobel prize in 2024. But the science behind rescuing people with blocked airways and clogged lungs by rectally delivering oxygen to the body is no joke. https://medicalxpress.com/news/2025-10-ignobel-butt-idea-closer-real.html Mon, 20 Oct 2025 15:19:35 EDT news680192364 Researchers at Cincinnati Children's Hospital Medical Center in collaboration with Roche, have developed a next-generation human liver organoid microarray platform that could help predict which drugs may cause harmful immune reactions in some people. https://medicalxpress.com/news/2025-10-human-liver-organoid-platform-immune.html Tue, 14 Oct 2025 14:25:05 EDT news679670702 Scientists from Cincinnati Children's and colleagues based in Japan report achieving a major step forward in organoid technology: producing liver tissue that grows its own internal blood vessels. https://medicalxpress.com/news/2025-06-liver-organoid-generates-specific-blood.html Wed, 25 Jun 2025 16:08:43 EDT news670086519 In 2017, scientists at Cincinnati Children's revealed that using antibiotics to protect newborns from dangerous infections often comes with a long-term consequence—a permanently underdeveloped immune system that can make children prone to poor outcomes from future lung infections. https://medicalxpress.com/news/2025-06-simple-supplement-healthy-newborn-gut.html Mon, 09 Jun 2025 11:00:01 EDT news668680943 Many women already know that preeclampsia—a dangerous form of high blood pressure during pregnancy—can lead to serious complications including kidney failure, stroke, and even death. Preeclampsia is also a well-known cause of preterm birth, which can pose a number of health risks for the baby. https://medicalxpress.com/news/2025-05-mom-hypertension-affect-preterm-infant.html Thu, 01 May 2025 04:41:04 EDT news665293261 Scientists at Cincinnati Children's along with an international team of researchers have discovered a surprising new connection between gut health and blood cancer risk—one that could transform how we think about aging, inflammation, and the early stages of leukemia. https://medicalxpress.com/news/2025-04-bacteria-aging-guts-elevate-leukemia.html Wed, 23 Apr 2025 11:00:01 EDT news664616461 One reason why our livers excel at clearing waste from our blood system is that the organ functions according to three key "zones" that perform specific major tasks. So, if scientists hope to create self-growing patches of liver organoid tissue that could help repair damaged organs, it's important that the lab-grown tissue faithfully reproduce such zones. https://medicalxpress.com/news/2025-04-human-multi-zonal-liver-organoids.html Wed, 16 Apr 2025 12:52:04 EDT news664026721 A groundbreaking consensus report on anaphylaxis—the severe reaction some people experience from bee stings, peanut butter exposures, medications, and the like—has been released by the Global Allergy and Asthma Excellence Network (GA2LEN) and recently published in The Journal of Allergy and Clinical Immunology. https://medicalxpress.com/news/2025-03-consensus-anaphylaxis-major-advancement-allergy.html Tue, 04 Mar 2025 12:43:03 EST news660314581 Despite ongoing progress, structural racism and health disparities continue to shape health care practices in ways health care providers may not even realize. A recent study in JAMA Network Open, published Feb. 28, 2025, shows that continued use of race-specific equations in the diagnostic process of children with asthma symptoms limits the identification of reduced lung function in Black children. https://medicalxpress.com/news/2025-02-omitting-lung-function-equations-asthma.html Fri, 28 Feb 2025 12:46:19 EST news659969175 A new study from scientists at Cincinnati Children's suggests there may be a way to further protect transplanted hearts from rejection by preparing the donor organ and the recipient with an anti-inflammatory antibody treatment before surgery occurs. https://medicalxpress.com/news/2024-08-pre-surgical-antibody-treatment-heart.html Mon, 12 Aug 2024 15:00:01 EDT news642672340 Our skin–the body's largest organ–provides the first line of defense against infections and many other threats to our health. Decades of research has shown that a wide range of diseases can occur, or become worse, when the skin cannot form an effective barrier. https://medicalxpress.com/news/2024-08-card14-protein-role-eczema-psoriasis.html Thu, 08 Aug 2024 13:36:20 EDT news642342976 Despite high hopes, a drug that wipes out the namesake cell type associated with the disease eosinophilic esophagitis (EoE) doesn't make patients feel better and doesn't reverse tissue damage in their throats. https://medicalxpress.com/news/2024-06-eosinophilic-esophagitis.html Thu, 27 Jun 2024 08:00:03 EDT news638693997 In a pioneering achievement, a research team led by experts at Cincinnati Children's has developed the world's first human mini-brain that incorporates a fully functional blood-brain barrier (BBB). https://medicalxpress.com/news/2024-05-brain-assembloids-human-mini-fully.html Mon, 20 May 2024 12:55:05 EDT news635428501 When treated with a novel protein function inhibitor called ESI1, mice that mimic the symptoms of multiple sclerosis (MS) and lab-prepared human brain cells both demonstrated the ability to regenerate vital myelin coatings that protect healthy axon function. https://medicalxpress.com/news/2024-05-small-molecule-early-stage-myelin.html Thu, 02 May 2024 12:34:06 EDT news633872040 Millions of working parents know the routine: bustle the kids off to childcare in the morning, work all day, then fight the daily traffic jams to get the kids back home. Something to drink, maybe a snack to munch, can help ease the commute. https://medicalxpress.com/news/2024-04-childcare-hour-window-healthier-habits.html Tue, 30 Apr 2024 15:09:03 EDT news633708541 In recent years, a growing body of research has shown that the human body can "remember" the pain of newborn injuries—including life-saving surgeries—all the way into adolescence. https://medicalxpress.com/news/2024-04-immune-cells-memory-early-life.html Thu, 18 Apr 2024 16:04:08 EDT news632675041 Thanks to an unusual application of game theory and machine learning technology, a large team of scientists led by experts at Cincinnati Children's has published the world's most detailed "atlas" of the many types of stem cells and early progenitors involved in producing human blood from diverse donors. https://medicalxpress.com/news/2024-03-atlas-date-human-blood-stem.html Thu, 21 Mar 2024 15:23:04 EDT news630253382 Imagine being able to count the different types of blood cells being formed inside the tiny bones of a mouse and pinpointing the strings and clusters of cells within the bone marrow that are responsible for producing specific types of blood cells. https://medicalxpress.com/news/2024-03-skeleton-wide-blood-cell-formation.html Wed, 20 Mar 2024 12:00:01 EDT news630146893 Numerous studies have raised alarms about how the COVID-19 pandemic disrupted learning, development and mental health among school-aged children. But few have focused on the effects felt by the 22 million children under age 6 who were not yet in school. https://medicalxpress.com/news/2024-02-covid-pandemic-kindergarten-readiness.html Mon, 05 Feb 2024 12:59:23 EST news626360359 An innovative computational tool dubbed "SNAF" may help the research world bring the emerging promise of cancer immunotherapy to a wider range of patients, according to a study published in Science Translational Medicine. https://medicalxpress.com/news/2024-01-tool-cancer-immunotherapy.html Wed, 17 Jan 2024 14:00:01 EST news624709976 One of the important breakthroughs that made it possible to program or reprogram cell fate more efficiently and with higher fidelity in a dish was discovering how to make use of a small set of molecular cowboys called pioneer transcription factors (TFs). https://phys.org/news/2024-01-transcription-factors-blaze-trail-cell.html Wed, 10 Jan 2024 11:00:10 EST news624106807