https://medicalxpress.com/ en-us provides the latest news from Cleveland Clinic New results from a clinical trial show promising outcomes for a gene-edited treatment for severe sickle cell disease, a genetic blood disorder with few curative options. After research conducted as part of the multicenter RUBY Trial, researchers have published their latest findings in the New England Journal of Medicine. Remarkably, 27 out of 28 patients did not have any painful sickle cell crises after treatment, achieving what physicians call a "functional cure." https://medicalxpress.com/news/2026-03-gene-therapy-success-severe-sickle.html Wed, 01 Apr 2026 17:00:08 EDT news694189321 As the use of injectable GLP-1 drugs continues to rise, questions persist about what happens after patients stop taking them in real-world settings. A new Cleveland Clinic analysis of nearly 8,000 patients suggests that discontinuing semaglutide and tirzepatide, on average, does not lead to significant weight regain in clinical practice, as many patients later restart the original medication or try an alternative obesity treatment. https://medicalxpress.com/news/2026-03-patients-glp-drugs-reveals-real.html Fri, 13 Mar 2026 15:50:01 EDT news692603115 New research by Cleveland Clinic and Dyania Health demonstrates how a medically trained large language model system can accurately and efficiently screen electronic medical records (EMRs) to identify patients who are eligible for a rare disease clinical trial. Published in The Journal of Cardiac Failure, the study offers real-world evidence that artificial intelligence (AI)-enabled medical chart review can improve the speed, accuracy, and equity of trial enrollment. https://medicalxpress.com/news/2026-03-ai-driven-accurately-potential-rare.html Tue, 03 Mar 2026 17:00:06 EST news691749421 Cleveland Clinic researchers have discovered that bacteria inside cancerous tumors may be key to understanding why immunotherapy works for some patients but not others. https://medicalxpress.com/news/2025-12-tumor-bacteria-linked-immunotherapy-resistance.html Fri, 02 Jan 2026 05:00:04 EST news686378909 Cleveland Clinic researchers are presenting final Phase I data from their novel study of a vaccine aimed at preventing triple-negative breast cancer, the most aggressive and lethal form of the disease. https://medicalxpress.com/news/2025-12-phase-trial-breast-cancer-vaccine.html Thu, 11 Dec 2025 18:00:01 EST news684664809 A team led by Cleveland Clinic's Kenneth Merz, Ph.D., and IBM's Antonio Mezzacapo, Ph.D., is developing quantum computing methods to simulate and study supramolecular processes that guide how entire molecules interact with each other. https://phys.org/news/2025-11-quantum-centric-supercomputing-simulates-supramolecular.html Tue, 18 Nov 2025 12:35:03 EST news682691702 New Cleveland Clinic research reveals that up to 5% of Americans—approximately 17 million people—carry genetic mutations or "variants" linked to increased cancer susceptibility, regardless of risk factors like personal or family cancer history. https://medicalxpress.com/news/2025-10-americans-genetic-mutations-cancer.html Mon, 27 Oct 2025 16:40:01 EDT news680801540 Researchers at Cleveland Clinic Children's have helped identify a previously unknown gene that increases the risk of developing osteosarcoma, the most common type of malignant bone tumor in children and young adults. https://medicalxpress.com/news/2025-10-reveals-genetic-link-common-pediatric.html Thu, 09 Oct 2025 16:00:01 EDT news679242841 Genetic testing can identify patients with HPV-positive throat cancer who may benefit from lower radiation doses, according to Cleveland Clinic research. The study, published in the Journal of Clinical Investigation, builds on a growing body of evidence that radiation treatment can be personalized using tumor genomics, potentially shifting treatment approaches from the norm, where radiation is prescribed at a uniform dose, to one called Genomic Adjusted Radiation Dose (GARD), where radiation is prescribed to a desired effect. https://medicalxpress.com/news/2025-09-gene-tailored-doses-hpv-throat.html Sat, 27 Sep 2025 07:20:36 EDT news678176425 A large Cleveland Clinic study has found that people with obesity and type 2 diabetes who undergo weight-loss surgery live longer and face fewer serious health problems compared with those treated with GLP-1 receptor agonist medicines alone. https://medicalxpress.com/news/2025-09-bariatric-surgery-weight-loss-greater.html Tue, 16 Sep 2025 05:00:05 EDT news677172341 Cleveland Clinic Cole Eye Institute researchers have identified a potential association between the use of GLP-1 receptor agonist (GLP-1RA) therapy and a reduced risk of non-infectious uveitis, a type of eye inflammation. https://medicalxpress.com/news/2025-08-obesity-medications-eye-inflammation.html Thu, 28 Aug 2025 13:14:03 EDT news675605641 Cleveland Clinic researchers have discovered a connection between elevated blood levels of TMAO (trimethylamine N-oxide)—a byproduct of gut bacteria digestion of nutrients found in red meat and other animal products—and a higher risk of abdominal aortic aneurysms. https://medicalxpress.com/news/2025-08-red-meat-gut-byproduct-linked.html Wed, 20 Aug 2025 11:00:12 EDT news674815831 A new study published by Cleveland Clinic researchers in Diabetes, Obesity and Metabolism investigating the genetic underpinnings of weight loss response has identified a gene, neurobeachin (NBEA), as a predictor of how individuals respond to GLP-1RAs, the class of medications behind popular treatments like liraglutide and semaglutide. https://medicalxpress.com/news/2025-07-genetic-predictor-weight-loss-glp.html Mon, 21 Jul 2025 10:05:32 EDT news672311125 Kenneth Merz, Ph.D., of Cleveland Clinic's Center for Computational Life Sciences and a team are exploring how quantum computers can work with supercomputers to better simulate molecule behavior. https://phys.org/news/2025-07-approach-combines-quantum-supercomputers-molecule.html Mon, 14 Jul 2025 12:44:02 EDT news671715837 Cleveland Clinic researchers are working to improve the way we use evolutionary modeling to understand drug resistance. The study, published in Science Advances, uses a new type of evolutionary model called a "fitness seascape" to incorporate a patient's dosage schedule into models that predict whether an infection will develop antibiotic resistance, and has found that inconsistent timing and missing early doses can lead to treatment failure. https://medicalxpress.com/news/2025-06-evolutionary-antibiotic-resistance-reveals-dose.html Fri, 13 Jun 2025 14:10:02 EDT news669040556 A Cleveland Clinic study shows that semaglutide and tirzepatide—injectable GLP-1 drugs for obesity—produce smaller weight loss in a real-world setting because patients discontinue treatment or use lower maintenance dosages. Treatment discontinuation also negatively impacted blood sugar control in patients with prediabetes. The study was published in the Obesity Journal. https://medicalxpress.com/news/2025-06-medications-obesity-smaller-weight-loss.html Tue, 10 Jun 2025 03:00:01 EDT news668679054 A team led by Kenneth Merz, Ph.D., Staff at Cleveland Clinic's Center for Computational Life Sciences, showed how quantum computers can be used for investigating how molecules act in aqueous solutions. https://phys.org/news/2025-06-hybrid-quantum-classical-molecular-behavior.html Thu, 05 Jun 2025 09:50:03 EDT news668335801 Cleveland Clinic virology researchers have found that a specific protein modification to the immune protein MDA5 is key to how human bodies detect and respond to viruses and viral replication. https://medicalxpress.com/news/2025-04-immune-protein-modification-curb-viral.html Thu, 10 Apr 2025 14:19:03 EDT news663513541 A Cleveland Clinic-led clinical trial of tolebrutinib, an investigational oral Bruton's tyrosine kinase inhibitor, a group of drugs originally developed to treat lymphomas and related blood disorders, demonstrated a 31% delay in the onset of six-month confirmed disability progression (CDP) in patients with non-relapsing secondary progressive multiple sclerosis (SPMS). https://medicalxpress.com/news/2025-04-trial-delay-disability-relapsing-secondary.html Tue, 08 Apr 2025 12:50:02 EDT news663259430 Kenneth Merz, Ph.D., of Cleveland Clinic's Center for Computational Life Sciences, and a research team are testing quantum computing's abilities in chemistry through integrating machine learning and quantum circuits. https://phys.org/news/2025-04-quantum-proton-affinity-superior-accuracy.html Wed, 02 Apr 2025 13:23:54 EDT news662819026 A team of researchers from Cleveland Clinic Genomic Medicine share insights from an early set of 19,000 patients to receive immune checkpoint inhibitor treatments for colorectal cancer in the U.S. https://medicalxpress.com/news/2025-03-analysis-colorectal-cancer-immunotherapy-treatment.html Thu, 20 Mar 2025 11:00:07 EDT news661679822 Cleveland Clinic researchers have developed and validated a prediction model that estimates the risk of developing colorectal cancer and advanced precancerous polyps in adults under 45 years old. The paper appears in Digestive Diseases and Sciences. https://medicalxpress.com/news/2025-03-team-score-early-onset-colorectal.html Mon, 03 Mar 2025 15:21:03 EST news660237661 Researchers from Cleveland Clinic's Genome Center have outlined the pathway human herpes simplex virus-1 (HSV1) can use to contribute to Alzheimer's disease in aging brains. In a report published in Alzheimer's & Dementia, investigators also share two FDA-approved, commercially available drugs that reverse this pathway in a laboratory setting. https://medicalxpress.com/news/2025-02-herpesviruses-contribute-alzheimer-disease-transposable.html Mon, 24 Feb 2025 16:26:33 EST news659636788 Researchers from the Cleveland Clinic Genome Center have successfully applied advanced artificial intelligence (AI) genetics models to Parkinson's disease. Researchers identified genetic factors in progression and FDA-approved drugs that can potentially be repurposed for PD treatment. https://medicalxpress.com/news/2025-01-ai-potential-genes-parkinson-disease.html Wed, 29 Jan 2025 09:12:04 EST news657364321 A Cleveland Clinic study shows that patients with obesity and fatty liver-related cirrhosis who had bariatric (weight-loss) surgery significantly lowered their future risk of developing serious liver complications compared with patients who received medical therapy alone. The results are published in Nature Medicine. https://medicalxpress.com/news/2025-01-bariatric-surgery-favorably-cirrhosis.html Mon, 27 Jan 2025 09:20:04 EST news657192001 Cleveland Clinic researchers have found definitive proof of a kidney microbiome that influences renal health and kidney stone formation, demonstrating that the urinary tract is not sterile and low levels of bacteria are normal. https://medicalxpress.com/news/2024-12-full-characterization-kidney-microbiome-potential.html Wed, 11 Dec 2024 11:52:04 EST news653140322 Cleveland Clinic Genome Center researchers have unraveled how immune cells called microglia can transform and drive harmful processes like neuroinflammation in Alzheimer's disease. The study, published in the journal Alzheimer's & Dementia, also integrates drug databases with real-world patient data to identify FDA-approved drugs that may be repurposed to target disease-associated microglia in Alzheimer's disease without affecting the healthy type. https://medicalxpress.com/news/2024-12-network-based-analyses-uncover-neuroinflammation.html Fri, 06 Dec 2024 13:31:05 EST news652714262 Cleveland Clinic developed a predictive model to identify patients at risk of developing gastric (stomach) cancer who may benefit from stomach cancer screening. The model is designed to identify who might need regular upper endoscopies to screen for stomach cancer. Although U.S. patients get routinely screened for other diseases, endoscopies—where a patient needs anesthesia—are more invasive. https://medicalxpress.com/news/2024-12-patients-stomach-cancer-screening.html Wed, 04 Dec 2024 14:51:03 EST news652546261 Cleveland Clinic researchers are presenting updated findings from their novel study of a vaccine aimed at preventing triple-negative breast cancer, the most aggressive and lethal form of the disease. https://medicalxpress.com/news/2024-11-breast-cancer-vaccine.html Fri, 08 Nov 2024 11:21:49 EST news650287302 Cleveland Clinic researchers found that a 12-week therapeutic virtual yoga program for chronic low back pain can be a feasible, safe and effective treatment option. The findings are published in JAMA Network Open. https://medicalxpress.com/news/2024-11-therapeutic-virtual-yoga-effective-chronic.html Fri, 01 Nov 2024 11:00:01 EDT news649668934