https://medicalxpress.com/ en-us provides the latest news from Garvan Institute of Medical Research Researchers at the Garvan Institute of Medical Research have uncovered a critical mechanism driving inflammation in mevalonate kinase deficiency (MKD), a rare but devastating autoinflammatory disorder. The study, published in Immunity, reveals that immune cells called natural killer (NK) cells are impaired in MKD, leading to an excessive inflammatory response when patients encounter infections. https://medicalxpress.com/news/2026-04-years-doctors-wrong-immune-culprit.html Thu, 30 Apr 2026 11:00:16 EDT news696757262 Prostate cancer affects one in five Australian men, making it the most common cancer in the country. Now, researchers at the Garvan Institute of Medical Research have produced the world's most detailed cellular "atlas" of early-stage prostate cancer, revealing the earliest changes that lead to the disease. https://medicalxpress.com/news/2026-03-cellular-atlas-prostate-cancer-avenues.html Wed, 25 Mar 2026 10:00:12 EDT news693651361 A discovery from Australian researchers could lead to better treatment for children with neuroblastoma, a cancer that currently claims 9 out of 10 young patients who experience recurrence. The team at the Garvan Institute of Medical Research in Sydney, Australia, found a drug combination that can bypass the cellular defenses these tumors develop that lead to relapse. https://medicalxpress.com/news/2025-11-drug-combination-sidesteps-resistance-aggressive.html Fri, 28 Nov 2025 14:00:04 EST news683393581 A Garvan-led clinical trial has found that using a common and inexpensive type 2 diabetes drug reduces insulin needs in type 1 diabetes, opening doors for improved management of the condition. https://medicalxpress.com/news/2025-11-cheap-century-drug-life-diabetes.html Mon, 24 Nov 2025 05:00:11 EST news682875841 A team of scientists at the Garvan Institute of Medical Research has discovered that inactivation of a stress pathway makes ER+ breast cancer cells ignore stress signals, allowing them to evade treatment. https://medicalxpress.com/news/2025-08-uncover-potential-mechanism-treatment-resistance.html Mon, 18 Aug 2025 07:38:46 EDT news674721523 A multinational team of researchers, co-led by the Garvan Institute of Medical Research, has developed and tested a new AI tool to better characterize the diversity of individual cells within tumors, opening doors for more targeted therapies for patients. https://medicalxpress.com/news/2025-06-ai-tool-distinct-cancer-cell.html Tue, 24 Jun 2025 10:00:01 EDT news669976898 Researchers at the Garvan Institute of Medical Research and UNSW Sydney have discovered why some people with celiac disease continue to suffer debilitating symptoms despite strictly avoiding gluten. https://medicalxpress.com/news/2025-05-rogue-immune-cells-gluten-free.html Thu, 15 May 2025 09:02:04 EDT news666518521 Sydney scientists have revealed why receiving a booster vaccine in the same arm as your first dose can generate a more effective immune response more quickly. The study, led by the Garvan Institute of Medical Research and the Kirby Institute at UNSW Sydney and published in the journal Cell, offers new insight that could help improve future vaccination strategies. https://medicalxpress.com/news/2025-04-left-arm-reveals-vaccination-site.html Mon, 28 Apr 2025 11:00:09 EDT news665047861 Researchers at the Garvan Institute of Medical Research have uncovered how pancreatic cancer hijacks a crucial metabolic "switch" to help it spread, revealing a potential new treatment strategy for this highly aggressive disease. https://medicalxpress.com/news/2025-03-metabolic-pancreatic-cancer.html Fri, 14 Mar 2025 09:58:03 EDT news661165081 A new study has uncovered that a gene variant common in Oceanian communities was misclassified as a potential cause of heart disease, highlighting the risk of the current diversity gap in genomics research which can pose a greater risk for misdiagnosis of people from non-European ancestries. https://medicalxpress.com/news/2025-03-case-misclassified-cardiomyopathy-gene-variant.html Wed, 05 Mar 2025 12:10:02 EST news660386161 Scientists at the Garvan Institute of Medical Research have discovered how a viral infection causes autoimmune disease, disproving a long-standing theory and opening a promising new approach to developing treatments for autoimmune conditions. https://medicalxpress.com/news/2025-01-storm-mutations-chronic-hepatitis-infection.html Wed, 15 Jan 2025 11:00:18 EST news656152802 A multinational collaboration co-led by the Garvan Institute of Medical Research has uncovered a potential explanation for why some cancer patients receiving a type of immunotherapy called checkpoint inhibitors experience increased susceptibility to common infections. https://medicalxpress.com/news/2024-11-reveals-common-cancer-immunotherapy-side.html Tue, 26 Nov 2024 12:44:04 EST news651847438 Researchers have mapped 50,000 of DNA's mysterious "knots" in the human genome. The innovative study of DNA's hidden structures may open up new approaches for treatment and diagnosis of diseases, including cancer. https://phys.org/news/2024-08-dna-mysterious-human-genome.html Thu, 29 Aug 2024 05:00:02 EDT news644077202 A molecule called nidogen-2 may be a key driver of pancreatic cancer progression and metastasis, offering a promising new treatment approach for this aggressive cancer, according to a Garvan Institute study. https://medicalxpress.com/news/2024-07-pancreatic-cancer-boost-chemotherapy.html Mon, 08 Jul 2024 11:09:48 EDT news639655785 Using artificial intelligence, Garvan Institute researchers have found potential cancer drivers hidden in so-called 'junk' regions of DNA, opening up possibilities for a new approach to diagnosis and treatment. https://medicalxpress.com/news/2024-07-class-cancer-mutations-junk-dna.html Wed, 03 Jul 2024 09:20:04 EDT news639217201 Researchers have discovered how the mechanical properties of tumors can prime cancer cells to better survive their spread to other organs. https://medicalxpress.com/news/2024-04-softer-tumors-fuel-aggressive-triple.html Fri, 12 Apr 2024 09:11:03 EDT news632131861 The epigenetic 'signature' of a rare, hard-to-diagnose breast tumor has been found by scientists at the Garvan Institute of Medical Research. The discovery could lead to improved treatment guidelines and better outcomes for patients with this rare disease. https://medicalxpress.com/news/2024-02-biomarkers-difficult-breast-tumor.html Fri, 02 Feb 2024 11:36:02 EST news626096160 Endocrine resistance—a major cause of breast cancer deaths—can be underpinned by an epigenetic change called DNA methylation, researchers at the Garvan Institute of Medical Research have discovered. The team successfully reversed this methylation to reduce cancer growth in patient-derived animal models. https://medicalxpress.com/news/2024-01-epigenetic-therapy-endocrine-resistant-breast.html Tue, 09 Jan 2024 10:21:04 EST news624018062 Bone may seem as if it's a hard, lifeless structure, but now the cells living within have been imaged in unprecedented detail, thanks to an innovative imaging method developed at the Garvan Institute of Medical Research. https://phys.org/news/2023-10-imaging-method-reveals-cells-bone.html Thu, 26 Oct 2023 10:48:35 EDT news617536106 Findings from the Garvan Institute of Medical Research reveal a new Australian drug that targets scar-like 'fibrotic' tissue within tumors shows promise for treating pancreatic ductal adenocarcinoma, one of the most aggressive forms of pancreatic cancer with a five-year survival rate of less than 10%. https://medicalxpress.com/news/2023-08-drug-scar-like-tissue-tumors-aggressive.html Tue, 29 Aug 2023 10:31:41 EDT news612523897 A study led by researchers at the Garvan Institute of Medical Research shows for the first time how a gene called RELA, known to regulate inflammation, also plays an essential role in maintaining normal blood-sugar levels. https://medicalxpress.com/news/2023-06-gene-clues-common-diabetes-side.html Wed, 14 Jun 2023 15:21:04 EDT news605974862 Studying stem cell samples from hundreds of individuals in the same culture dish, using a method developed at the Garvan Institute of Medical Research, could have transformative potential for personalized treatments and the study of complex human traits. https://medicalxpress.com/news/2023-06-team-village-dish-stem-cell.html Fri, 09 Jun 2023 10:29:00 EDT news605525308 When you're stressed, a high-calorie snack may seem like a comforting go-to. But this combination has an unhealthy downside. According to Sydney scientists, stress combined with calorie-dense comfort food creates changes in the brain that drive more eating, boost cravings for sweet, highly palatable food and lead to excess weight gain. https://medicalxpress.com/news/2023-06-chronic-stress-brain-crave-comfort.html Thu, 08 Jun 2023 11:00:15 EDT news605430124 A team at the Garvan Institute of Medical Research has discovered a group of brain cells that boosts appetite when there is a prolonged surplus of energy in the body, such as excess fat accumulation in obesity. https://medicalxpress.com/news/2023-05-brain-cells-appetite-obesity.html Wed, 17 May 2023 11:00:01 EDT news603537105 Pancreatic cancer drug response and resistance has been uncovered in unprecedented detail, thanks to a research tool developed at the Garvan Institute. https://medicalxpress.com/news/2023-04-image-drug-response-resistant-pockets.html Fri, 28 Apr 2023 10:20:23 EDT news601896016 A discovery about gene variants of an inflammation 'brake' brings scientists a step closer to personalised treatment for patients at risk of kidney disease and kidney failure. https://medicalxpress.com/news/2023-04-inflammation-gene-reveal-outcomes-kidney.html Sun, 23 Apr 2023 13:56:50 EDT news601476960 The cellular glitches underlying a rare genetic disorder called activated PI3K Delta syndrome 2 (APDS2) have been identified by researchers at the Garvan Institute of Medical Research. The disorder is caused by genetic variations that disrupt immune cell signaling through a protein called PI3K. https://medicalxpress.com/news/2023-03-insights-rare-genetic-immune-disorders.html Tue, 21 Mar 2023 12:14:03 EDT news598619641 Cancer cells have an innate randomness in their ability to respond to chemotherapy, which is another tool in their arsenal of resisting treatment, new research led by the Garvan Institute of Medical Research shows. https://medicalxpress.com/news/2023-03-tumor-cells-response-chemotherapy-driven.html Fri, 03 Mar 2023 14:00:04 EST news597056477 For almost 140 years, the origin and behavior of an enigmatic cell type inside lymph nodes, called a tingible body macrophage, has remained a mystery. Now, for the first time, scientists at the Garvan Institute of Medical Research have tracked the cell's lifecycle and function, with implications for our understanding of autoimmune disorders. https://medicalxpress.com/news/2023-03-specialized-garbage-disposal-cell-implicated.html Thu, 02 Mar 2023 11:46:04 EST news596979961 A new class of SARS-CoV-2 antibodies has been shown to neutralize multiple variants of the virus, providing hope for a better antiviral medication to prevent and treat COVID-19 symptoms in at-risk individuals, according to a new study from the Garvan Institute of Medical Research. https://medicalxpress.com/news/2023-02-class-antibodies-covid-.html Tue, 14 Feb 2023 12:10:04 EST news595598991