https://medicalxpress.com/ en-us provides the latest news from The Mount Sinai Hospital A new review from the Icahn School of Medicine at Mount Sinai and the Hospital Clínic de Barcelona provides one of the clearest roadmaps to date for understanding and treating liver cancer, one of the deadliest cancers worldwide. Published in Cell, the study, "Hallmarks of Liver Cancer: Therapeutic Implications", applies the widely used "Hallmarks of Cancer" framework to liver tumors, linking the biology of the disease to treatment strategies, including immunotherapy and precision medicine approaches, particularly in the approximately 45% of bile duct cancers that harbor targetable mutations. https://medicalxpress.com/news/2026-04-liver-cancer-roadmap-links-tumor.html Thu, 16 Apr 2026 16:40:02 EDT news695572900 Mount Sinai researchers have created an analytic tool using machine learning that can predict cardiovascular disease risk in millions of patients with obstructive sleep apnea, a serious sleep disorder, according to findings recently published in Communications Medicine. The team said their study is the first to provide estimates of whether continuous positive airway pressure (CPAP), a widely used therapy for obstructive sleep apnea, will increase or decrease an individual's cardiovascular risk. It highlights the potential for precision medicine and varied approaches to tailor clinical care and reduce cardiovascular disease risk in vulnerable patients. https://medicalxpress.com/news/2026-04-ai-cpap-massively-heart-apnea.html Thu, 09 Apr 2026 17:40:03 EDT news694971481 Using a microaxial flow pump prior to and during cardiac stenting procedures for patients with severe heart attacks who don't have cardiogenic shock does not significantly reduce heart damage. That is the major finding from the first clinical trial of its kind to analyze the effect of resting the heart in high-risk heart attack patients to see if it reduces the size of the heart attack. https://medicalxpress.com/news/2026-03-microaxial-outcomes-high-heart-patients.html Sun, 05 Apr 2026 12:00:01 EDT news694094706 Researchers at the Icahn School of Medicine at Mount Sinai and the Mount Sinai Tisch Cancer Center have found that adults aged 80 and older with early-stage lung cancer can safely undergo surgery and achieve outcomes comparable to younger patients, challenging longstanding assumptions about age and cancer treatment. https://medicalxpress.com/news/2026-04-lung-cancer-surgery-safe-patients.html Thu, 02 Apr 2026 13:20:03 EDT news694353661 Researchers from the Icahn School of Medicine at Mount Sinai have discovered a molecular switch in neurons that limits the regrowth of damaged axonal fibers. The findings, published in the journal Nature, show that blocking a protein called the aryl hydrocarbon receptor (AHR) may help neural regeneration and restore function after injuries to the peripheral nerves or spinal cord. https://medicalxpress.com/news/2026-03-molecular-limits-axonal-regeneration-injury.html Wed, 01 Apr 2026 11:00:09 EDT news694189141 A collaborative research study co-led by scientists at the Icahn School of Medicine at Mount Sinai and the Liber Institute for Brain Development has for the first time identified a biological process that may help explain how the brain develops differently in people with Down syndrome. https://medicalxpress.com/news/2026-03-syndrome-early-rna-shifts-reshape.html Tue, 31 Mar 2026 05:00:07 EDT news694089447 Researchers at the Icahn School of Medicine at Mount Sinai in New York have identified and described a previously unknown recessive neurodevelopmental disorder (NDD) that appears to be the most prevalent ever discovered. The condition is caused by changes in a small noncoding gene called RNU2-2. It is estimated to affect thousands of individuals in the United States and account for about 10% of all recessive NDD cases with a known genetic cause. https://medicalxpress.com/news/2026-03-newly-recessive-neurodevelopmental-disorder-prevalent.html Mon, 30 Mar 2026 05:00:05 EDT news693836881 A new study, co-led by researchers at the Icahn School of Medicine at Mount Sinai and published March 30 in Nature Medicine, demonstrates that genes associated with autism risk are largely the same across people of different ancestries. The findings, based on one of the largest genomic studies of Latin American individuals to date, provide strong evidence that the genetic architecture of autism is consistent across diverse populations. They underscore the importance of expanding genetic research beyond individuals of European ancestry. https://medicalxpress.com/news/2026-03-autism-genes-ancestries-reveals.html Mon, 30 Mar 2026 05:00:01 EDT news693834602 Mount Sinai researchers have published the first organ-wide human skin spatial atlas from across the body. It provides an unprecedentedly detailed view of healthy human skin, revealing cellular composition and functional mechanisms of skin from more than a dozen unique sites on the body, including the scalp and sole. https://medicalxpress.com/news/2026-03-spatial-atlas-reveals-unique-cell.html Mon, 23 Mar 2026 18:20:01 EDT news693499441 Researchers at the Icahn School of Medicine at Mount Sinai and the Mount Sinai Tisch Cancer Center have discovered a biological pathway that helps explain why some bladder cancers do not respond well to immunotherapy. Their findings, published in Cancer Discovery, show that common signs of inflammation in the blood are linked to immune cells inside tumors that block the body's ability to fight cancer. https://medicalxpress.com/news/2026-03-inflammatory-immune-pathway-immunotherapy-resistance.html Wed, 18 Mar 2026 11:40:06 EDT news693052381 Researchers have identified a distinct and reproducible gene expression program associated with neurotransmission in the living human brain, offering unprecedented insight into the molecular mechanisms that support human cognition, emotion, and behavior. The findings were published in Molecular Psychiatry. https://medicalxpress.com/news/2026-03-gene-linked-neurotransmission-human-brain.html Mon, 16 Mar 2026 19:20:03 EDT news692895736 As artificial intelligence (AI) becomes more common in health care, from managing records to assisting with medication decisions, researchers at the Icahn School of Medicine at Mount Sinai are asking an important question: How well does AI hold up when the workload gets intense at a health system scale? https://medicalxpress.com/news/2026-03-orchestrated-multi-agent-ai-outperform.html Wed, 11 Mar 2026 13:00:05 EDT news692448111 What if doctors could tell you a disease was coming years before you felt a single symptom—and stop it in its tracks? That is the goal of a sweeping new research initiative launched by the Icahn School of Medicine at Mount Sinai in collaboration with the Uniformed Services University of the Health Sciences (USU) and the Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF). https://medicalxpress.com/news/2026-03-multidisciplinary-blood-samples-diseases-years.html Mon, 02 Mar 2026 09:20:03 EST news691665302 A team of researchers at the Icahn School of Medicine at Mount Sinai, Weill Cornell Medicine, and other institutions have uncovered a key biological explanation for why eczema so often starts in childhood. The study, in young mice, found that some types of immune cells in early-life skin are more reactive than those in adults, a difference that may help explain why children are more vulnerable to inflammation and allergic skin disease. https://medicalxpress.com/news/2026-02-eczema-childhood-clues-early-immune.html Wed, 25 Feb 2026 11:00:05 EST news691161181 ChatGPT Health, a widely used consumer artificial intelligence (AI) tool that provides health guidance directly to the public—including advice about how urgently to seek medical care—may fail to direct users appropriately to emergency care in a significant number of serious cases, according to researchers at the Icahn School of Medicine at Mount Sinai. The study, fast-tracked in the February 23, 2026 online issue of Nature Medicine, is the first independent safety evaluation of the large language model (LLM)-based tool since its January 2026 launch. It also identified serious concerns with the tool's suicide-crisis safeguards. https://medicalxpress.com/news/2026-02-chatgpt-health-independent-safety.html Tue, 24 Feb 2026 12:20:01 EST news691156202 Researchers at the Icahn School of Medicine at Mount Sinai have reported promising findings that may help redefine treatment for patients with muscle-invasive bladder cancer, a potentially aggressive form of the disease traditionally treated with surgical removal of the bladder. The study, published in the Proceedings of the National Academy of Sciences, demonstrates that ultra-sensitive testing of tumor-derived DNA in blood and urine may help identify patients who can safely preserve their bladder without compromising cancer outcomes. https://medicalxpress.com/news/2026-02-blood-urine-dna-bladder-cancer.html Thu, 19 Feb 2026 13:20:03 EST news690728718 Researchers at the Mount Sinai Kravis Children's Heart Center led a multicenter effort to develop and validate an artificial intelligence (AI) tool that can analyze a standard electrocardiogram (ECG) to identify patients with repaired tetralogy of Fallot who may be at risk for harmful heart changes typically detected by cardiac MRI. The study, supported by the National Institutes of Health, is published in the European Heart Journal: Digital Health. https://medicalxpress.com/news/2026-02-ai-powered-ecg-lifelong-heart.html Wed, 18 Feb 2026 12:19:46 EST news690639541 Babies born between 2003 and 2006 were exposed to many more "forever chemicals" before birth than scientists previously understood, according to new research published in Environmental Science & Technology. https://medicalxpress.com/news/2026-02-babies-exposed-chemicals-birth-previously.html Wed, 18 Feb 2026 09:40:06 EST news690629263 A new study from the Icahn School of Medicine at Mount Sinai and the Mount Sinai Tisch Cancer Center finds that pleurectomy/decortication, a lung-sparing surgery, can be performed safely with low mortality in carefully selected patients with pleural mesothelioma, a rare and aggressive cancer most often caused by asbestos exposure. https://medicalxpress.com/news/2026-02-evidence-lung-surgery-mesothelioma-patients.html Thu, 12 Feb 2026 13:00:28 EST news690123602 A team of leading clinical research scientists from the Departments of Psychiatry and Dermatology at the Icahn School of Medicine at Mount Sinai has found that the serum of patients with major depressive disorder shares immune abnormalities with inflammatory skin diseases, most notably the common Th2 immune pathway that is implicated in atopic dermatitis. Because these skin diseases are treatable, the findings suggest new therapeutic possibilities for psychiatric illness as well. https://medicalxpress.com/news/2026-02-major-depressive-disorder-immune-abnormalities.html Wed, 11 Feb 2026 15:56:35 EST news690047761 Medical artificial intelligence (AI) is often described as a way to make patient care safer by helping clinicians manage information. A new study by the Icahn School of Medicine at Mount Sinai and collaborators confronts a critical vulnerability: when a medical lie enters the system, can AI pass it on as if it were true? https://medicalxpress.com/news/2026-02-medical-ai-large-llms-health.html Mon, 09 Feb 2026 18:30:05 EST news689848617 Mount Sinai researchers have identified a cellular mechanism linking infections from influenza A viruses (IAVs) to cardiovascular disease, providing critical insights on how influenza can damage the heart and increase the risk of a heart attack or other major cardiovascular event. https://medicalxpress.com/news/2026-02-flu-season-strain-heart-mrna.html Mon, 09 Feb 2026 11:00:05 EST news689593021 Scientists at the Icahn School of Medicine at Mount Sinai have identified an important immune response that helps explain why some cancer patients benefit from immunotherapy while others do not. https://medicalxpress.com/news/2026-01-antibody-immune-cells-cancer-immunotherapy.html Tue, 27 Jan 2026 19:50:01 EST news688744223 Researchers at the Icahn School of Medicine at Mount Sinai, in collaboration with other leading institutions across the country, have published an innovative study that provides radiation oncologists with practical guidance to identify and protect female sexual organs during pelvic cancer treatment. https://medicalxpress.com/news/2026-01-advance-female-sexual-anatomy-pelvic.html Tue, 27 Jan 2026 11:25:25 EST news688735502 A new comprehensive review from researchers at the Icahn School of Medicine at Mount Sinai details how decades of cancer vaccine research are converging into a new era of more precise, personalized, and effective immunotherapies, particularly when combined with other cancer treatments. The work examines the evolution of therapeutic cancer vaccines, with a special focus on neoantigen-based vaccines—highly personalized vaccines designed using genetic mutations unique to a patient's tumor. https://medicalxpress.com/news/2026-01-cancer-vaccines-personalized-combination-treatment.html Thu, 22 Jan 2026 14:57:05 EST news688316161 Scientists at the Icahn School of Medicine at Mount Sinai have developed an experimental immunotherapy that takes an unconventional approach to metastatic cancer: instead of going after cancer cells directly, it targets the cells that protect them. https://medicalxpress.com/news/2026-01-experimental-car-therapy-tumor-immune.html Thu, 22 Jan 2026 13:19:13 EST news688310281 Researchers at the Icahn School of Medicine at Mount Sinai have characterized how cellular senescence—a biological process in which aging cells change how they function—is associated with human brain structure in both development and late life. https://medicalxpress.com/news/2026-01-cellular-senescence-linked-brain-lifespan.html Thu, 22 Jan 2026 11:00:15 EST news688227061 A team of researchers has conducted the largest and most comprehensive genome-wide association study (GWAS) to date of schizophrenia in individuals of African ancestry. https://medicalxpress.com/news/2026-01-largest-genetic-schizophrenia-african-ancestry.html Wed, 21 Jan 2026 15:06:25 EST news688230302 Exposure to per- and polyfluoroalkyl substances (PFAS), a class of highly persistent environmental chemicals commonly referred to as "forever chemicals," is associated with a higher risk of gestational diabetes mellitus and altered markers of insulin resistance and insulin secretion, according to a new systematic review and meta-analysis led by researchers at the Icahn School of Medicine at Mount Sinai. https://medicalxpress.com/news/2026-01-exposure-chemicals-linked-higher-gestational.html Wed, 14 Jan 2026 13:30:01 EST news687617545 Researchers have identified bradycardia—an abnormally low heart rate—as a symptom of xylazine-opioid overdose. This breakthrough finding from the Icahn School of Medicine at Mount Sinai may help emergency medicine physicians detect whether patients have been exposed to xylazine, a drug that is increasingly found as an additive to the illicit fentanyl supply, particularly in the Northeast. https://medicalxpress.com/news/2026-01-abnormally-heart-xylazine-fentanyl-overdose.html Tue, 13 Jan 2026 10:00:04 EST news687441721