https://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Scientists from Great Ormond Street Hospital (GOSH) and University College London (UCL) have created the first lab‑grown esophagus—the food pipe—shown to safely replace a full section of the organ and restore normal function, including swallowing, in a growing animal without the need for immunosuppression. https://medicalxpress.com/news/2026-03-tissue-children-born-esophagus.html Fri, 20 Mar 2026 06:00:01 EDT news693131341 An international research team led by the Levenberg Laboratory in the Faculty of Biomedical Engineering at the Technion-Israel Institute of Technology has succeeded in developing a first-of-its-kind, three-dimensional implant that combines muscle and fat tissues, a lymphatic network, and a hierarchical blood vessel network. The researchers' findings are published in Cell Biomaterials. https://medicalxpress.com/news/2026-03-implant-treatment-significant-tissue-loss.html Tue, 17 Mar 2026 17:30:01 EDT news692985244 A Japanese research team has demonstrated in rat experiments that stem cells from human primary tooth pulp may help treat chronic-phase cerebral palsy. "This is the first animal study to show that stem cell treatment works even after motor deficits have already appeared," said Clinical Professor Yoshiaki Sato of Nagoya University Hospital, the study's corresponding author. The findings are published in the journal Stem Cell Research & Therapy. https://medicalxpress.com/news/2026-03-stem-cells-human-baby-teeth.html Wed, 04 Mar 2026 09:40:02 EST news691838881 Multiple myeloma, a cancer of the bone marrow, remains difficult to treat despite modern CAR T cell therapies. In recent research, a team led by Dr. Armin Rehm presents an improved immunotherapy that recognizes two distinct features of malignant cells to destroy the cancer more effectively. https://medicalxpress.com/news/2026-01-pronged-malignant-cells-immunotherapy.html Thu, 08 Jan 2026 16:51:48 EST news687113461 The first-in-human clinical phase I trial assessing the feasibility and safety of WDVAX, an immunostimulatory biomaterial-based cancer vaccine, in a cohort of 21 patients with stage 4 metastatic melanoma, was concluded with positive outcomes that encourage future vaccine developments and trials to test them in combination with immune checkpoint inhibitor therapies. https://medicalxpress.com/news/2025-12-clinical-trial-personalized-cancer-vaccine.html Mon, 15 Dec 2025 15:29:42 EST news685034941 A patient with synovial sarcoma, a soft-tissue cancer that usually occurs in the large joints of the arms and legs, is the first in Arizona treated with a new immune cell therapy known as TECELRA at the HonorHealth Research Institute. https://medicalxpress.com/news/2025-12-patient-arizona-immune-cell-therapy.html Sun, 14 Dec 2025 14:10:01 EST news684763372 A team led by scientists at King's College London, in collaboration with national and international partners, has discovered how a specific group of immune cells in the gut—Group 3 Innate Lymphoid Cells (ILC3s)—promote intestinal health by activating a powerful signaling molecule called Transforming Growth Factor Beta 1 (TGF-β1). The findings could lead to new treatments for inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis. https://medicalxpress.com/news/2025-12-gut-cells-aid-intestinal-ibd.html Thu, 11 Dec 2025 12:37:32 EST news684679022 Preliminary results from two trials of the gene therapy exagamglogene autotemcel (exa-cel) suggest the therapy offers an effective cure for beta-thalassemia and sickle cell disease in children younger than 12. Researchers say the therapy's potential to offer a cure at an early age—before organ damage accumulates—could make exa-cel even more beneficial in children than adults. https://medicalxpress.com/news/2025-12-exa-cel-gene-therapy-effective.html Sat, 06 Dec 2025 07:00:06 EST news684057301 The number of traumatic amputations is rising worldwide—caused by road traffic accidents, accidents at work or during leisure activities, but also as a result of terrorist attacks or war. Only a few specialist clinics are able to perform autologous replantation on patients with often life-threatening injuries, i.e., reattaching severed limbs to the body in such a way that they regain their function completely or at least to a limited extent. In addition, the operation must be performed quickly, as the amputated limbs are stored in an ice bag as standard and can only survive for a few hours without a blood supply. https://medicalxpress.com/news/2025-11-aims-severed-limbs.html Sat, 29 Nov 2025 15:30:01 EST news683548247 Researchers at Cincinnati Children's Hospital Medical Center in collaboration with Roche, have developed a next-generation human liver organoid microarray platform that could help predict which drugs may cause harmful immune reactions in some people. https://medicalxpress.com/news/2025-10-human-liver-organoid-platform-immune.html Tue, 14 Oct 2025 14:25:05 EDT news679670702 Researchers at the First Affiliated Hospital of the University of Science and Technology of China claim that an in vivo CD8 T-cell-targeted lipid nanoparticle carrying CD19 CAR mRNA (HN2301) generated transient CAR T cells that rapidly depleted B cells and reduced disease activity in five patients with treatment resistant systemic lupus erythematosus. https://medicalxpress.com/news/2025-10-patient-lupus-car-cell-feasibility.html Mon, 06 Oct 2025 13:20:03 EDT news678968137 To undergo kidney dialysis, doctors must first surgically create an access route—an arteriovenous fistula—usually in an arm, a conduit that will accommodate hemodialysis treatments. It is a routine outpatient procedure performed for years worldwide. https://medicalxpress.com/news/2025-09-stem-cells-fat-tissue-kidney.html Tue, 30 Sep 2025 07:00:01 EDT news678368289 For African American patients undergoing mastectomy, the risk of complications and the postoperative appearance of the breast are among the important drivers of preferences for breast reconstruction, reports a study in Plastic and Reconstructive Surgery. https://medicalxpress.com/news/2025-08-breast-reconstruction-african-american-women.html Thu, 28 Aug 2025 15:09:04 EDT news675612541 Researchers from Tel Aviv University and Sheba Tel Hashomer Medical Center have developed an innovative bioengineered skin equivalent for grafting in burn victims. The bioengineered skin produced from the patient's own cells is more stable, robust, and flexible than current treatments, making it easier to handle. https://medicalxpress.com/news/2025-06-bioengineered-skin-preclinical.html Wed, 11 Jun 2025 14:15:05 EDT news668870102 Yale researchers have built a 3D-bioprinted synthetic aorta that they have successfully implanted into rats. This technology could advance the treatment of cardiovascular diseases such as coronary artery disease or peripheral arterial disease by allowing scientists to engineer and replace blood vessels in humans. https://medicalxpress.com/news/2025-05-bioprinted-aortas-successfully-implanted-rats.html Tue, 06 May 2025 09:50:08 EDT news665743801 In recent years, cell therapies have developed alongside chemotherapy and immunotherapy to become a new pillar in the treatment of patients with blood and lymph gland cancer. In solid tumors, such as skin, lung, or bone and soft tissue cancer (sarcomas), they have not yet proven themselves as a treatment method. https://medicalxpress.com/news/2025-04-cell-therapy-results-advanced-tumor.html Fri, 25 Apr 2025 11:07:23 EDT news664798033 Cells with electrophysiological activity obtained at the University of the Basque Country (UPV/EHU) are opening up new avenues for the study of neurodegenerative diseases and the development of future autologous transplants. https://medicalxpress.com/news/2025-04-cells-similar-neurons-human-dental.html Mon, 07 Apr 2025 13:09:47 EDT news663250175 An expanded clinical trial that tested an experimental stem cell treatment for blinding cornea injuries found the treatment was feasible and safe in 14 patients who were treated and followed for 18 months, and there was a high proportion of complete or partial success. https://medicalxpress.com/news/2025-03-stem-cell-therapy-irreversible-corneal.html Tue, 04 Mar 2025 05:00:01 EST news660216001 CAR T cell therapy is one of the most promising new cancer treatments to emerge in recent years. It involves removing a patient's own immune T cells and engineering them to recognize specific targets on the surface of the cancer cell. https://medicalxpress.com/news/2025-01-viral-protein-nef-enables-shelf.html Fri, 31 Jan 2025 03:20:46 EST news657516039 For women undergoing breast reconstruction after mastectomy, older age is associated with small but significant increases in certain complications, reports a study in the journal Plastic & Reconstructive Surgery. https://medicalxpress.com/news/2024-12-older-age-linked-complications-breast.html Fri, 20 Dec 2024 13:04:38 EST news653922274 Two million bone transplants are performed worldwide yearly, including half a million in the United States alone. Yet, a QUT-led study has found surgeons are slow to adopt newly developed biomaterials or tissue-engineered solutions. https://medicalxpress.com/news/2024-12-surgeons-cautious-bone-methods.html Tue, 17 Dec 2024 10:29:23 EST news653653758 A team of UC Davis Health researchers has shown that CD34+ stem cells can be safely administered into retinitis pigmentosa (RP) patients' eyes and may offer therapeutic benefits. The phase 1 trial also confirmed that these specialized cells can be readily isolated from the patient's own bone marrow. The study was published in the journal Ophthalmology Science. https://medicalxpress.com/news/2024-11-early-stage-trial-stem-cell.html Tue, 26 Nov 2024 17:03:03 EST news651862981 The pelvic floor supports our organs in the abdomen and holds them firmly in place. In women, however, the pelvic floor can be weakened by pregnancy and vaginal births, for example, or due to heredity, age or weight. https://medicalxpress.com/news/2024-11-robotic-surgery-uterus-prolapse.html Wed, 13 Nov 2024 14:15:04 EST news650729702 Researchers have developed a novel method to enhance the ability of mesenchymal stromal cells (MSCs) to generate cartilage tissue by adding ascorbic acid (AA) during MSC expansion. https://medicalxpress.com/news/2024-10-method-effectiveness-msc-therapy-cartilage.html Tue, 15 Oct 2024 15:07:05 EDT news648223621 An accelerated course of radiation therapy does not increase complications for patients who undergo breast reconstruction following a mastectomy, new research shows. Findings of the large, Phase III RT CHARM trial (Alliance A221505) were presented at the American Society for Radiation Oncology (ASTRO) Annual Meeting. https://medicalxpress.com/news/2024-09-mastectomy-therapy-shortened-patients-breast.html Mon, 30 Sep 2024 10:00:01 EDT news646643844 Various forms of arthritis afflict nearly 600 million people worldwide and add $16.5 billion to the United States' health care bill, yet there are few engineered cartilage tissue therapies available to sufferers. https://medicalxpress.com/news/2024-09-advocate-tissue-approach-arthritis-relief.html Wed, 04 Sep 2024 17:27:03 EDT news644689622 Researchers from AMBER and Trinity, led by Dr. David Hoey, have successfully replicated the behavior of a blood vessel and its guiding structure to regenerate damaged tissue. https://medicalxpress.com/news/2024-08-bioengineers-hybrid-grafts-combat-cardiovascular.html Thu, 22 Aug 2024 10:11:03 EDT news643540261 People with Parkinson's disease are receiving a new treatment in a clinical trial started after University of Wisconsin–Madison scientists demonstrated the safety and feasibility of the therapeutic delivery method in a study of non-human primates. https://medicalxpress.com/news/2024-07-brain-cell-grafts-monkeys-human.html Mon, 29 Jul 2024 12:53:31 EDT news641476403 Some private UK biobanks may be misleading expectant parents about the value of storing umbilical cord blood to treat life-threatening diseases that may arise in their child in the future, reveals an investigation by The BMJ. https://medicalxpress.com/news/2024-07-companies-overinflating-umbilical-cord-blood.html Wed, 24 Jul 2024 18:30:01 EDT news641052781 Researchers from University of California San Diego have found that two of the most frequently administered stem cell therapies, which are often used interchangeably, actually contain completely different types of cells. The results challenge the current "one-cell-cures-all" paradigm in orthopedic stem cell therapeutics and highlight the need for more informed and rigorous characterization of injectable stem cell therapies before they are marketed for use in patients. https://medicalxpress.com/news/2024-07-stem-cell-therapies-equally-dont.html Fri, 12 Jul 2024 14:00:01 EDT news639994619