https://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. As instigators of immunity, monoclonal antibodies are marvels of modern medicine, lab-made proteins that can treat cancers, autoimmune diseases, and many other conditions. With the market for these therapies forecast to double by 2030, it might seem that the only thing they can't do is grow fast enough. New research from the University of Oklahoma aims to put an end to that limitation, too. https://medicalxpress.com/news/2026-02-ai-antibody-drug-production.html Mon, 09 Feb 2026 16:40:04 EST news689873354 A research team from POSTECH and ImmunoBiome in Korea, led by Professor Sin-Hyeog Im, has uncovered a new mechanism showing how butyrate—a short-chain fatty acid produced by gut commensal bacteria—enhances T follicular helper (Tfh) cell activity to promote antibody production and strengthen mucosal vaccine efficacy. This study identifies a new microbiota–immune–antibody production axis linking microbial metabolism to mucosal immune responses, providing a strategy to maximize the protective effects of mucosal vaccines. The findings are published in the journal Microbiome. https://medicalxpress.com/news/2026-02-gut-microbe-derived-butyrate-immune.html Thu, 05 Feb 2026 11:00:40 EST news689511601 An experimental pill called enlicitide slashed levels of low-density lipoprotein (LDL) cholesterol, commonly known as "bad" cholesterol, by up to 60%, according to a new phase three clinical trial published in the New England Journal of Medicine. If approved by the Food and Drug Administration, this novel medication could help millions in the U.S. significantly reduce their risk of heart attacks and strokes. https://medicalxpress.com/news/2026-02-experimental-pill-bad-cholesterol.html Thu, 05 Feb 2026 10:06:53 EST news689508361 Scientists at The Wistar Institute have developed an HIV vaccine candidate that achieves something never before observed in the field: inducing neutralizing antibodies against HIV after a single immunization in nonhuman primates. The innovative approach, published in Nature Immunology, could significantly shorten and simplify HIV vaccination protocols, making them more accessible worldwide. https://medicalxpress.com/news/2026-02-shot-hiv-vaccine-candidate-neutralizing.html Tue, 03 Feb 2026 06:36:51 EST news689322961 Antibodies are the immune system's precision tools for recognizing and neutralizing viruses, bacteria and other foreign substances that can make us ill. These proteins circulate in the bloodstream and are built from chains of amino acids. Yet pinning down the exact amino acid sequence of an antibody is surprisingly tough. https://medicalxpress.com/news/2026-01-benchmark-antibodies-dataset-aims-standardize.html Fri, 30 Jan 2026 12:35:25 EST news688998901 Monoclonal antibodies (mAbs) aid the body against autoimmune diseases and cancer, among other things. Patients have to pick up the medicine every few weeks. It would be easier for them to be able to inject the medicine themselves at home, but this would only be possible if the medications were highly concentrated but not too viscous. https://medicalxpress.com/news/2026-01-simulations-antibody-drug-viscosity-paving.html Fri, 16 Jan 2026 10:45:20 EST news687782648 Allergies and asthma affect an increasing number of children worldwide, but now an international research group led by DTU has identified a previously unknown mechanism that can reduce the risk of allergies and asthma later in life. The study shows that children are less likely to develop these diseases if, as infants, they are colonized with certain bifidobacteria that produce a substance in the gut—a so-called metabolite—that dampens immune responses to allergens. https://medicalxpress.com/news/2026-01-infant-gut-bacteria-key-asthma.html Mon, 12 Jan 2026 11:16:36 EST news687438961 Researchers at the University of Southampton have developed a promising new way to bolster the body's immune system response to cancer. https://medicalxpress.com/news/2026-01-multi-pronged-antibodies-boost-immune.html Thu, 08 Jan 2026 14:18:39 EST news687104281 A new study analyzing the immune response to COVID-19 in a Catalan cohort of health workers sheds light on an important question: does it matter whether a person was first infected or first vaccinated? https://medicalxpress.com/news/2025-12-infected-vaccinated-covid-immunity.html Tue, 23 Dec 2025 04:09:15 EST news685685280 A new artificial intelligence model could help design antibodies that better protect the body against viruses and disease. The AI model, known as ImmunoMatch, can predict and identify correct protein pairings within antibodies, potentially helping to strengthen the immune system. The research was conducted by a team from the University of Surrey and University College London and is published in Nature Methods. https://medicalxpress.com/news/2025-12-ai-sequences-antibodies-therapeutic-treatments.html Tue, 16 Dec 2025 13:18:28 EST news685113481 Today's influenza vaccines primarily prevent infection in individuals, but new research led by the University of Michigan and the Institut Pasteur suggests that incorporating antibodies generated after infection could lead to more powerful vaccines by also reducing person-to-person transmission. https://medicalxpress.com/news/2025-12-vaccine-flu-antibodies-role-transmission.html Mon, 15 Dec 2025 13:23:39 EST news685027382 Children with a rare form of cancer called neuroblastoma which hasn't responded to initial treatment or that has relapsed may benefit from adding antibody treatment to usual chemotherapy, according to new results from a clinical trial. https://medicalxpress.com/news/2025-12-adding-antibody-treatment-chemo-boosts.html Fri, 12 Dec 2025 16:00:01 EST news684750901 A review on autoimmune neurological diseases reveals what occurs in our body when the immune system, by mistake, produces antibodies that target a protein essential for the normal functioning of nerves. The result is hyperexcitability, that is, uncontrolled electrical signals that trigger continuous, involuntary muscle activity. https://medicalxpress.com/news/2025-12-exploring-misguided-antibodies-nervous.html Fri, 12 Dec 2025 12:54:21 EST news684766442 Federal officials say the U.S. Food and Drug Administration (FDA) is reviewing reports of possible deaths in adults and children following COVID-19 vaccination. https://medicalxpress.com/news/2025-12-fda-deaths-covid-vaccination.html Thu, 11 Dec 2025 10:50:02 EST news684672491 Children who grow up in farming communities have long been known to develop far fewer allergies than their urban peers. A new study from the University of Rochester Medical Center (URMC), offers one possible reason why: their immune systems may mature faster, and breast milk appears to play an important supporting role. https://medicalxpress.com/news/2025-12-farm-families-earlier-immune-maturation.html Thu, 11 Dec 2025 09:46:23 EST news684668761 With the help of artificial intelligence, an international team of researchers has made the first major inroad to date toward a new and more effective way to fight the monkeypox virus (MPXV), which causes a painful and sometimes deadly disease that can be especially dangerous for children, pregnant women and immunocompromised people. https://medicalxpress.com/news/2025-12-ai-key-mpox-protein-vaccine.html Wed, 10 Dec 2025 14:00:01 EST news684508624 Adding tucatinib (Tukysa) to first-line maintenance therapy with trastuzumab (Herceptin) and pertuzumab (Perjeta) delayed disease progression in patients with HER2-positive metastatic breast cancer, potentially extending time off chemotherapy, according to results from a Phase III clinical trial HER2CLIMB-05 presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9–12, 2025. https://medicalxpress.com/news/2025-12-adding-tucatinib-line-maintenance-therapy.html Wed, 10 Dec 2025 08:21:45 EST news684577262 A new clinical trial suggests that pairing bispecific antibodies and antibody-drug conjugates with CAR T-cell therapy may sharply boost one-year progression-free survival for people with aggressive lymphoma. https://medicalxpress.com/news/2025-12-combination-approach-aims-car-durable.html Mon, 08 Dec 2025 16:30:03 EST news684405836 In a recent preclinical study, researchers from The University of Texas MD Anderson Cancer Center developed an antibody therapy called 77A that showed an ability to overcome treatment resistance in blood cancers, such as myeloma and lymphoma, as well as solid tumors. https://medicalxpress.com/news/2025-12-antibody-boosts-immune-response-blood.html Mon, 08 Dec 2025 13:41:38 EST news684423661 Finland was the first country to offer the zoonotic avian influenza A(H5N8) vaccine manufactured by Seqirus to at-risk occupational groups following the extensive clade 2.3.4.4b A(H5N1) outbreak affecting wild birds and fur farms in Finland in 2023. https://medicalxpress.com/news/2025-12-h5n8-avian-influenza-vaccine-robust.html Fri, 05 Dec 2025 12:57:28 EST news684161822 Scientists led by Stephanie Eisenbarth, MD, Ph.D., the Roy and Elaine Patterson Professor of Medicine and director of the Center for Human Immunobiology, have discovered how critical IgA antibodies are produced through unexpected cellular pathways, findings that may help inform the design of more effective vaccines to prevent infections, according to a recent study published in Immunity. https://medicalxpress.com/news/2025-12-unexpected-pathway-iga-antibody-production.html Mon, 01 Dec 2025 15:33:29 EST news683825581 Crimean-Congo hemorrhagic fever (CCHF) is one of the world's most dangerous yet overlooked infectious diseases. Spread by ticks and livestock, the virus causes sudden fever, organ failure, and internal bleeding, killing up to 40% of those infected. Outbreaks have been reported across parts of Africa, Asia, Eastern Europe, and the Middle East. Despite decades of research, no approved vaccines or treatments exist. https://medicalxpress.com/news/2025-11-experimental-vaccine-rapid-deadly-borne.html Fri, 21 Nov 2025 15:29:47 EST news682961375 Researchers at the Icahn School of Medicine at Mount Sinai and collaborators have created the most comprehensive map to date showing how antibodies attach to the SARS-CoV-2 virus, which causes COVID-19, and how viral mutations weaken that attachment. https://medicalxpress.com/news/2025-11-covid-variants-outsmart-immune.html Fri, 21 Nov 2025 12:26:05 EST news682950362 A clinical oncology research team at the LKS Faculty of Medicine, the University of Hong Kong (HKUMed), in collaboration with the US National Cancer Institute (NCI), has developed an innovative big data platform, called the "Cancer Immunology Data Engine" (CIDE). This state-of-the-art platform integrates clinical outcomes from 5,957 cancer patients worldwide who received immunotherapy, along with comprehensive multi-omics datasets covering 17 cancer types and comprising 8,575 tumor samples. https://medicalxpress.com/news/2025-11-cancer-immunology-big-platform-advancing.html Wed, 19 Nov 2025 12:05:04 EST news682776301 Polycystic kidney disease (PKD) is a debilitating hereditary condition in which fluid-filled sacs form and proliferate in the kidneys. Over time, the painful, growing cysts rob the organs of their function, often leading to dialysis in advanced cases. There is currently no cure. https://medicalxpress.com/news/2025-11-magic-bullet-polycystic-kidney-disease.html Wed, 19 Nov 2025 11:33:04 EST news682774381 Researchers at the University of California San Diego School of Medicine have identified a promising new therapy for triple-negative breast cancer (TNBC), which is among the most aggressive and difficult-to-treat forms of the disease. https://medicalxpress.com/news/2025-11-precision-therapy-breast-cancer-source.html Mon, 17 Nov 2025 11:34:03 EST news682601641 A team of researchers at the University of Pittsburgh has developed a skin patch that can detect antibodies associated with COVID and flu infections. It's orders of magnitude more sensitive than existing tests, uses just a half volt of electricity, and can return results in 10 minutes. https://medicalxpress.com/news/2025-11-needle-flucovid-vaccines-effective.html Mon, 10 Nov 2025 14:14:02 EST news682006441 Intravenous immunoglobulin (IVIG) therapy involves infusing patients with naturally occurring IgG antibodies to treat autoimmune conditions. With origins dating back to the 1950s, IVIG is currently FDA-approved for four diseases but widely prescribed off-label to treat more than 80 additional ones because it's often the only medicine that has any impact on these conditions. https://medicalxpress.com/news/2025-11-highly-potent-ivig-autoimmunity-human.html Thu, 06 Nov 2025 15:50:03 EST news681666131 A study led by André Veillette, a researcher at the Montreal Clinical Research Institute (IRCM) and a professor in the Faculty of Medicine at University of Montreal, sheds new light on the complexity of the immune system and its role in cancer treatment. https://medicalxpress.com/news/2025-11-cancer-immunotherapy-isnt-effective.html Wed, 05 Nov 2025 09:47:59 EST news681558473 Pancreatic cancer is notoriously hard to treat and often resists the most advanced immunotherapies. Northwestern Medicine scientists have uncovered a novel explanation for that resistance: Pancreatic tumors use a sugar-based disguise to hide from the immune system. The scientists also created an antibody therapy that blocks the sugar-mediated "don't-attack" signal. https://medicalxpress.com/news/2025-10-antibody-therapy-foils-pancreatic-cancer.html Mon, 03 Nov 2025 10:00:02 EST news681121742