https://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. Gliomas are cancers that originate directly in the brain, instead of spreading to the brain from other parts of the body. These cancers cannot be cured with conventional cancer treatments, as they spread into healthy brain tissue and cannot be removed via surgical procedures. https://medicalxpress.com/news/2025-12-brain-tumor-cells-neurons-vice.html Mon, 22 Dec 2025 10:00:01 EST news685360022 High-grade gliomas are aggressive brain tumors with poor prognosis, largely because even after surgical removal, infiltrative residual tumor cells often regrow during the latency before radiotherapy, leading to recurrence. The standard chemoradiotherapy only modestly improves survival. A crucial window of vulnerability arises post-surgery, before radiotherapy begins, where residual tumor cells are not well addressed by systemic chemotherapy. https://medicalxpress.com/news/2025-09-gel-aggressive-brain-tumors.html Fri, 26 Sep 2025 12:33:18 EDT news678108795 A new study, led by researchers at Children's Hospital of Philadelphia (CHOP), identified tiny pieces of messenger RNA that are missing in pediatric high-grade glioma tumors but not in normal brain tissues. Preclinical research indicates that these missing RNA fragments can make difficult-to-treat tumors more responsive to immunotherapy. The findings were recently published in the journal Cell Reports. https://medicalxpress.com/news/2025-08-messenger-rna-fragments-key-immunotherapy.html Fri, 15 Aug 2025 14:12:38 EDT news674485949 A collaborative study between Dana-Farber Cancer Institute and the Broad Institute found that 8.9% of children with glioma, the most common form of pediatric brain tumor, have alterations in the fibroblast growth factor receptor (FGFR) family of proteins, and that these gliomas may be sensitive to existing U.S. Food and Drug Administration (FDA) approved inhibitors that broadly block FGFR. https://medicalxpress.com/news/2025-07-therapies-pediatric-gliomas.html Thu, 31 Jul 2025 16:12:00 EDT news673197115 A group led by the Department of Neurosurgery at the Brain Research Institute, Niigata University, has successfully treated a patient with a brainstem glioma harboring a rare IDH2 mutation. The case report was published online in the journal Frontiers in Oncology. https://medicalxpress.com/news/2025-07-temozolomide-adult-brainstem-glioma-patient.html Thu, 17 Jul 2025 05:04:28 EDT news671947463 In a clinical practice guideline issued by the American Society for Radiation Oncology and published online June 25 in Practical Radiation Oncology, updated recommendations are presented for the management of World Health Organization (WHO) grade 4 adult-type diffuse glioma, focusing on radiation therapy (RT) and/or adjunctive therapies. https://medicalxpress.com/news/2025-07-issued-grade-diffuse-glioma.html Tue, 08 Jul 2025 15:32:41 EDT news671207552 Camryn was diagnosed with a low-grade glioma at age two after her parents noticed a lazy eye. Sixteen years, 11 brain surgeries and over six years of chemotherapy treatment, Camryn is now transitioning from The Hospital for Sick Children (SickKids) into adult care. https://medicalxpress.com/news/2025-06-molecular-unveils-insights-adolescent-young.html Tue, 17 Jun 2025 11:18:04 EDT news669377881 In the largest ever study of its kind, an analysis of entire tumor genomes has provided the most complete picture yet of an aggressive type of brain cancer. https://medicalxpress.com/news/2025-05-comprehensive-tumor-genome-analysis-blueprint.html Wed, 28 May 2025 14:20:03 EDT news667660801 Mayo Clinic researchers have identified a potential new way to monitor the progression of high-grade gliomas, one of the most aggressive types of brain cancer. Their feasibility study suggests that a personalized blood test tailored to each patient's tumor DNA could provide a faster and less invasive way to determine if the cancer is advancing. https://medicalxpress.com/news/2025-04-personalized-approach-brain-cancer.html Thu, 24 Apr 2025 13:30:05 EDT news664718719 Pediatric high-grade gliomas, particularly H3K27M diffuse midline gliomas (DMG), are aggressive malignant brain tumors with a poor prognosis. Previous research suggests that platelet-derived growth factor receptor alpha (PDGFRA) appears to play a multifaceted role in the pathogenesis of both adult and pediatric high-grade gliomas. Not only are genetic alterations of PDGFRA common in patients with pediatric high-grade gliomas, but elevated PDGFRA expression has been shown to be key in driving growth of DMG tumors. https://medicalxpress.com/news/2025-03-pediatric-high-grade-gliomas-reveals.html Thu, 27 Mar 2025 04:52:44 EDT news662269959 High-grade glioma, an aggressive form of pediatric and adult brain cancer, is challenging to treat given the tumor location, incidence of recurrence and difficulty for drugs to cross the blood-brain barrier. https://medicalxpress.com/news/2025-03-repurposed-fda-drug-high-grade.html Thu, 13 Mar 2025 15:16:45 EDT news661097801 Gene mutations caused by exposure to certain chemical compounds have been linked to the development of gliomas, the most common type of malignant brain tumor. New research reveals that among patients with gliomas, these mutations are more common in firefighters than in individuals with other occupations. The findings are published online in Cancer. https://medicalxpress.com/news/2025-03-firefighters-higher-brain-cancer-gene.html Mon, 10 Mar 2025 03:00:01 EDT news660559541 A group led by the Department of Neurosurgery, Brain Research Institute, Niigata University, has succeeded in the diagnosis of leptomeningeal disease in diffuse midline gliomas by detecting H3K27M-mutant droplets from circulating tumor DNA of cerebrospinal fluid taken from these patients. https://medicalxpress.com/news/2025-01-succeeds-early-diagnosis-leptomeningeal-disease.html Mon, 27 Jan 2025 14:48:02 EST news657211681 There seems to be no association between hormone therapy (HT) and glioma risk among U.S. women, according to a study published online Jan. 14 in Menopause. https://medicalxpress.com/news/2025-01-hormone-therapy-glioma-women.html Wed, 15 Jan 2025 15:10:07 EST news656175065 Women are more likely to have such debilitating conditions as osteoporosis, migraines, Alzheimer disease, depression, multiple sclerosis, and brain tumors. Sex hormones are often blamed. However, a new study suggests no link between hormone therapy (HT) and common brain tumors known as gliomas. https://medicalxpress.com/news/2025-01-large-scale-link-common-brain.html Wed, 15 Jan 2025 07:09:57 EST news656147394 Every week, Harvard Medical School neuro-oncologist Annie Hsieh treats patients with gliomas—the most common type of brain cancer, including the deadliest, glioblastoma. https://medicalxpress.com/news/2024-12-neurontumor-brain-illuminates-formation-gliomas.html Thu, 05 Dec 2024 14:57:52 EST news652633067 Gliomas are the most common brain tumors, and many start off growing slowly as "low-grade" tumors before inevitably becoming aggressive, lethal, and "high grade." New research offers an explanation for this deadly transformation. https://medicalxpress.com/news/2024-11-brain-tumor-source-glioma-deadly.html Thu, 21 Nov 2024 08:55:52 EST news651401747 Researchers at Baylor College of Medicine and the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital have uncovered a new cell type in the human brain. https://medicalxpress.com/news/2024-09-human-brain-cancers-electrical-impulses.html Thu, 05 Sep 2024 11:00:01 EDT news644743501 CDK4/6 inhibitors, which are already FDA approved for the treatment of other forms of cancer, show early signs of promise in the treatment of a subtype of pediatric high-grade glioma, according to new research from Dana-Farber Cancer Institute and the Institute of Cancer Research in London. Treatment of a patient with a second relapse of this glioma subtype and no other treatment options resulted in 18 months of progression-free survival. https://medicalxpress.com/news/2024-09-adolescent-glioma-subtype-cdk46-inhibitor.html Wed, 04 Sep 2024 14:53:30 EDT news644680404 Glioma represents the most common central nervous system cancer in adults. The current classification scheme uses molecular alterations, particularly IDH1.R132H, to stratify lesions into distinct prognostic groups. https://medicalxpress.com/news/2024-09-blood-based-assay-idh1r132h-mutant.html Mon, 02 Sep 2024 09:53:39 EDT news644489618 A new drug for treatment of a type of brain cancer, called IDH-mutant low-grade glioma, was approved Aug. 6 by the U.S. Food and Drug Administration (FDA). The promising new drug stems from a 2008 genetic discovery made at the Johns Hopkins Kimmel Cancer Center. https://medicalxpress.com/news/2024-08-fda-drug-brain-cancer-gene.html Wed, 07 Aug 2024 10:37:22 EDT news642245838 Vorasidenib has been approved by the U.S. Food and Drug Administration (FDA) for patients with Grade 2 gliomas with IDH1 or IDH2 mutations. https://medicalxpress.com/news/2024-08-fda-therapy-glioma-patients-decades.html Wed, 07 Aug 2024 07:09:49 EDT news642233383 In August 2023, a team of researchers including Dr. Eduard Porta, group leader at the Josep Carreras Institute, published a thorough analysis of the effects of cancer driver alterations found across different cancer types, ranging from epigenetic dysregulation to protein-protein interactions. That study provided a deeper perspective on cancer and yielded valuable data for clinical research in the future. https://medicalxpress.com/news/2024-07-proteogenomics-analysis-high-grade-gliomas.html Wed, 10 Jul 2024 12:35:56 EDT news639833753 A study from the laboratory of Shi-Yuan Cheng, Ph.D., professor in the Ken and Ruth Davee Department of Neurology's Division of Neuro-oncology, has identified novel mechanisms underlying RNA splicing events within glioma tumor cells, mechanisms which may serve as novel therapeutic targets, according to findings published in the Journal of Clinical Investigation. https://medicalxpress.com/news/2024-05-genetic-mechanisms-therapeutic-glioma.html Fri, 17 May 2024 10:36:04 EDT news635160961 A study in mice by researchers at the School of Medicine indicates that brain injury can lead to brain tumors in susceptible individuals. For this study, they used mice that model people with neurofibromatosis type 1 (NF1), a genetic disorder that causes brain tumors. https://medicalxpress.com/news/2024-05-brain-tumors-linked-injury-mouse.html Thu, 09 May 2024 12:27:02 EDT news634476421 Investigators at the UCLA Health Jonsson Comprehensive Cancer Center have pinpointed a combination immunotherapy treatment that enhances the immune response for people with malignant gliomas, an aggressive type of brain tumor that is fast growing and difficult to treat. https://medicalxpress.com/news/2024-05-benefits-adding-immune-boosting-agent.html Thu, 09 May 2024 12:18:05 EDT news634475881 Northwestern Medicine investigators led by Amy Heimberger, MD, Ph.D., the Jean Malnati Miller Professor of Brain Tumor Research and vice chair for Research in the Department of Neurological Surgery, have discovered a new mechanism in which cancer-associated fibroblasts mediate immune suppression in glioma tumors. https://medicalxpress.com/news/2024-03-immune-inhibitor-glioma.html Thu, 21 Mar 2024 11:43:04 EDT news630240182 A new research paper titled "BCAS1 defines a heterogeneous cell population in diffuse gliomas" has been published in Oncotarget. https://medicalxpress.com/news/2024-01-bcas1-heterogeneous-cell-population-diffuse.html Wed, 31 Jan 2024 13:30:29 EST news625930225 Diffuse gliomas are malignant brain tumors and cannot be optimally examined by conventional imaging using MRI. Amino acid PET can better visualize the activity and spread of gliomas. An international research group (RANO Group) led by MedUni Vienna and LMU Munich has now established the first international criteria for standardized imaging of gliomas using amino acid PET. This groundbreaking work has been published in The Lancet Oncology. https://medicalxpress.com/news/2024-01-team-framework-imaging-diagnostics-brain.html Wed, 03 Jan 2024 10:17:03 EST news623499421 Diffuse gliomas, which account for the majority of malignant brain tumors in adults, comprise astrocytoma, oligodendroglioma, and glioblastoma. Current diagnosis of glioma types requires combining both histological features and molecular characteristics. https://medicalxpress.com/news/2023-11-advancing-neuropathology-ai-driven-classification-diffuse.html Fri, 24 Nov 2023 09:49:46 EST news620041783