https://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. Researchers from Children's Hospital of Philadelphia (CHOP) have developed a method to help cancer immunotherapies reach otherwise "invisible" tumors by helping guide therapies to their appropriate targets. This could be particularly useful for very difficult-to-treat tumors like neuroblastoma. The findings appear in Science Advances. https://medicalxpress.com/news/2026-01-protein-complex-immunotherapies-hard-neuroblastoma.html Thu, 08 Jan 2026 16:45:30 EST news687113101 Using machine learning and a large volume of data on genes and existing drugs, researchers at Lund University in Sweden have identified a combination of statins and phenothiazines that is particularly promising in the treatment of the aggressive form of neuroblastoma. The results from experimental trials showed slowing of tumor growth and higher survival rates. https://medicalxpress.com/news/2025-12-machine-statin-phenothiazine-combo-neuroblastoma.html Mon, 29 Dec 2025 09:10:04 EST news686216381 Children with a rare form of cancer called neuroblastoma which hasn't responded to initial treatment or that has relapsed may benefit from adding antibody treatment to usual chemotherapy, according to new results from a clinical trial. https://medicalxpress.com/news/2025-12-adding-antibody-treatment-chemo-boosts.html Fri, 12 Dec 2025 16:00:01 EST news684750901 A discovery from Australian researchers could lead to better treatment for children with neuroblastoma, a cancer that currently claims 9 out of 10 young patients who experience recurrence. The team at the Garvan Institute of Medical Research in Sydney, Australia, found a drug combination that can bypass the cellular defenses these tumors develop that lead to relapse. https://medicalxpress.com/news/2025-11-drug-combination-sidesteps-resistance-aggressive.html Fri, 28 Nov 2025 14:00:04 EST news683393581 Neuroblastoma is a type of cancer that affects the sympathetic nervous system in young children and is often difficult to treat, especially when the tumor cells carry multiple copies of the MYCN gene. https://medicalxpress.com/news/2025-10-higher-hif2-aggressive-childhood-cancer.html Wed, 22 Oct 2025 15:21:38 EDT news680365294 Within the last two decades, multiple stem cell transplants and immunotherapy have been added to intensive chemotherapy as the standard of care for high-risk neuroblastoma, drastically improving survival of this childhood cancer. https://medicalxpress.com/news/2025-10-survivors-high-neuroblastoma-substantial-late.html Mon, 20 Oct 2025 16:56:04 EDT news680198161 Researchers at Children's Hospital of Philadelphia (CHOP) found that combining a specialized diet with an approved medication interrupts the growth of high-risk neuroblastoma, a deadly pediatric cancer, by reprogramming tumor behavior. The findings were published in the journal Nature. https://medicalxpress.com/news/2025-09-diet-medication-combo-growth-aggressive.html Thu, 25 Sep 2025 11:02:07 EDT news678016923 Gene expression governs whether neuroblastoma tumor cells exist in either the adrenergic (differentiated and sensitive to treatment) or mesenchymal (less differentiated and therapy-resistant) cell state. Tumors may switch between states, confounding treatment efforts. A study from St. Jude Children's Research Hospital indicates that the extent of this plasticity is underreported, but there is a way to circumvent this challenge therapeutically. https://medicalxpress.com/news/2025-09-molecular-harnesses-power-immune-neuroblastoma.html Wed, 17 Sep 2025 09:34:04 EDT news677320442 From Bambino Gesù Children's Hospital in Rome comes a report that a third-generation CAR T cell therapy targeting GD2, designated GD2–CART01, induced durable remissions and long-term survival in children with high-risk metastatic, relapsed, or refractory neuroblastoma. https://medicalxpress.com/news/2025-09-gd2-car-treatment-durable-remissions.html Mon, 15 Sep 2025 13:30:07 EDT news677159795 A new study led by Children's Hospital Los Angeles has found a novel mechanism behind neuroblastoma progression: the shape and structure of the extracellular matrix. https://medicalxpress.com/news/2025-07-key-mechanism-neuroblastoma.html Tue, 15 Jul 2025 07:19:24 EDT news671782759 Neuroblastoma is a cancer that affects the sympathetic nervous system of children. It is unusual among cancers because it shows a range of outcomes: from aggressive, potentially fatal progression to a unique phenomenon where the tumor spontaneously regresses even without treatment. https://medicalxpress.com/news/2025-06-cancer-cells-wont-commit-good.html Tue, 24 Jun 2025 12:00:02 EDT news669977341 Researchers at Karolinska Institutet and Lund University in Sweden have identified a new treatment strategy for neuroblastoma, an aggressive form of childhood cancer. By combining two antioxidant enzyme inhibitors, they have converted cancer cells in mice into healthy nerve cells. https://medicalxpress.com/news/2025-06-enzyme-inhibitor-strategy-neuroblastoma-cells.html Mon, 16 Jun 2025 15:00:01 EDT news669301921 High-risk neuroblastoma kills roughly half of affected children because the tumor can switch cell identity and evade therapy. By combining single-cell multi-omics with spatial transcriptomics, researchers at Karolinska Institutet have constructed a cell-by-cell roadmap of these state transitions. The paper is published in the journal Developmental Cell. https://medicalxpress.com/news/2025-05-cell-roadmap-reveals-key-transcription.html Mon, 12 May 2025 11:23:03 EDT news666267781 Researchers at Children's Hospital of Philadelphia (CHOP) highlighted the success of anaplastic lymphoma kinase (ALK) inhibition therapy in treating hereditary neuroblastoma, a rare subset of a common childhood cancer. Researchers suggest that the findings, published recently in JCO Precision Oncology, could help establish a new standard of care. https://medicalxpress.com/news/2025-05-standard-families-hereditary-neuroblastoma-linked.html Tue, 06 May 2025 17:23:03 EDT news665770981 Black and Hispanic children with high-risk neuroblastoma experience worse survival outcomes than their white peers, even when treated in frontline clinical trials, according to a study led by a UT Southwestern Medical Center researcher. https://medicalxpress.com/news/2025-04-black-hispanic-children-high-neuroblastoma.html Wed, 30 Apr 2025 11:34:04 EDT news665231641 Researchers at Children's Hospital of Philadelphia (CHOP) developed a longitudinal atlas of neuroblastoma, a common and potentially deadly childhood cancer, to gain a deeper understanding into precise molecular mechanisms underlying why and how certain treatments eventually become ineffective. https://medicalxpress.com/news/2025-04-cell-atlas-uncover-significant-shifts.html Mon, 14 Apr 2025 13:14:04 EDT news663855241 Neuroblastoma is a solid tumor that occurs in children. When high-risk, the disease has a poor prognosis. Decades ago, adding the drug retinoic acid to neuroblastoma treatment increased survival by 10–15%. However, this effect was only evident in post-chemotherapy consolidation after bulky primary tumors had largely been eliminated. Why retinoic acid is effective in this setting but not against primary tumors, has been speculated about for nearly 50 years. https://medicalxpress.com/news/2025-02-scientists-mystery-drug-retinoic-acid.html Fri, 28 Feb 2025 13:24:53 EST news659971489 A patient has achieved over 18 years of remission from neuroblastoma, a type of nerve cell cancer, following treatment with chimeric antigen receptor (CAR) T cell therapy and without requiring any additional treatments. The findings are published in Nature Medicine. https://medicalxpress.com/news/2025-02-patient-nerve-cell-cancer-remission.html Mon, 17 Feb 2025 11:45:03 EST news659015102 Neuroblastoma is the most common extracranial solid tumor in children, with nearly 50% of cases diagnosed at an advanced stage, often with metastatic disease. Despite advances in treatment, survival rates for high-risk and relapsed/refractory neuroblastoma remain dismal, and options like autologous stem cell transplantation and immunotherapy are frequently unavailable in low- and middle-income countries. https://medicalxpress.com/news/2025-01-metronomic-chemotherapy-approach-pediatric-neuroblastoma.html Thu, 23 Jan 2025 16:38:03 EST news656872681 Researchers in the group of Associate Professor Ninib Baryawno, Department of Women's and Children's Health, KI, have published their work, titled "Comparative Single-Cell Transcriptomics of Human Neuroblastoma and Preclinical Models Reveals Conservation of an Adrenergic Cell State," in Cancer Research. https://medicalxpress.com/news/2025-01-bridging-gap-mirror-human-tumors.html Wed, 15 Jan 2025 10:12:02 EST news656158314 The survival rate for children with a rare but deadly cancer could one day be improved by adding an existing drug—which is currently used to manage excess copper in the body—to their treatment. https://medicalxpress.com/news/2024-12-copper-key-rare-childhood-cancer.html Thu, 12 Dec 2024 12:16:47 EST news653228195 Blocking the METTL3 protein can increase sensitivity to chemotherapy in neuroblastoma, according to research from the University of Gothenburg. The study shows how specific RNA modifications affect gene expression in the early development of neuroblastoma. https://medicalxpress.com/news/2024-11-inhibiting-mettl3-protein-high-neuroblastoma.html Tue, 12 Nov 2024 14:21:04 EST news650643661 Researchers from Karolinska Institutet have made a significant breakthrough in the study of childhood neuroblastoma, a type of cancer that begins before birth during the early stages of adrenal gland development. https://medicalxpress.com/news/2024-09-discovery-tumor-cell-childhood-cancer.html Wed, 11 Sep 2024 15:56:03 EDT news645288961 A new molecular imaging technique that pairs a novel tracer with a next-generation PET/CT scanner can identify neuroblastoma in children with high sensitivity, requiring a scan time of only minutes and no sedation or anesthesia. With its ability to accurately diagnose neuroblastoma, this technique, known as 18F-MFBG LAFOV PET/CT, has the potential to impact therapeutic decision-making for children with this disease. https://medicalxpress.com/news/2024-08-petct-technique-accurately-neuroblastoma-children.html Wed, 21 Aug 2024 16:49:03 EDT news643477741 Researchers at Children's Hospital of Philadelphia (CHOP) announced a significant breakthrough in understanding chemotherapy resistance in high-risk neuroblastoma, a common and potentially deadly childhood cancer arising within the peripheral nervous system. https://medicalxpress.com/news/2024-08-malignant-cells-responsible-relapse-high.html Wed, 14 Aug 2024 13:31:03 EDT news642861058 Scientists have discovered a new insight into the genetic pathway of childhood cancer, offering new hope for tailored treatments. https://medicalxpress.com/news/2024-05-stem-cells-insight-genetic-pathway.html Tue, 14 May 2024 11:46:07 EDT news634905962 Neuroblastoma is a common pediatric cancer that originates in developing nerve cells outside the brain. While increasingly intensive treatments have improved the survival of patients with high-risk neuroblastoma, currently more than 40% of patients do not survive. https://medicalxpress.com/news/2024-05-drug-rna-modifications-neuroblastoma.html Fri, 03 May 2024 15:10:19 EDT news633967812 Researchers have identified new variations in neuroblastoma that could lead to a more accurate prognosis and better-targeted treatments for this devastating childhood cancer. https://medicalxpress.com/news/2024-04-neuroblastoma-subgroups-distinct-prognoses-potential.html Tue, 09 Apr 2024 10:00:00 EDT news631875597 Neuroblastoma, one of the most common childhood cancers, is classified as a developmental cancer because it arises prenatally during the formation of organs and tissues. It originates from cancer cells that develop in neuroblasts, a type of immature nerve tissue, and primarily affects the adrenal glands. https://medicalxpress.com/news/2024-03-successfully-mimics-complex-neuroblastoma-vasculature.html Thu, 28 Mar 2024 09:35:45 EDT news630837339 The MYCN oncoprotein (proteins related to the growth of cancer cells) plays a key role in starting, advancing and making it difficult to treat various human cancers. When MYCN is overactive, especially in high-risk neuroblastoma (childhood cancer often found in the adrenal glands), the tumors become less responsive to immunotherapy—a treatment that uses the body's immune system to fight cancer. Still, recognition of this problem has not led to any effective strategies to tackle this problem. https://medicalxpress.com/news/2024-03-molecule-neuroblastoma-immunosuppression-aggressiveness.html Fri, 15 Mar 2024 14:00:01 EDT news629718357