https://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. A team of researchers have identified a fundamental mechanism that links the 24-hour circadian cycle to the precise repair of DNA breaks. This study, conducted by researchers from the Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER) and the University of Seville, in collaboration with the Virgen Macarena University Hospital, focused on the circadian protein Cryptochrome1 (CRY1), suggests that the time of day when radiotherapy is administered can significantly influence the effectiveness of treatment for certain types of cancer. The paper is published in Nature Communications. https://medicalxpress.com/news/2026-01-radiotherapy-effective-day.html Fri, 30 Jan 2026 08:30:34 EST news688984202 Mayo Clinic researchers have developed a promising gene-editing therapy that directly corrects a genetic mutation responsible for autosomal dominant polycystic kidney disease (ADPKD), the most common inherited kidney disorder. https://medicalxpress.com/news/2026-01-dose-base-pkd1-mutation-survival.html Thu, 29 Jan 2026 13:48:41 EST news688916862 While current clinical trials for cardiac regeneration using induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) employ immunosuppressive regimens used in heart transplants, the precise immunosuppressive regimen needed remains elusive. Now, researchers have identified optimized immunosuppressive strategies that allow transplanted iPSC-CMs to survive without immune rejection in non-human primates. These findings advance the clinical potential of regenerative therapies for severe heart failure, addressing a major challenge in translating stem cell science into effective human treatments. https://medicalxpress.com/news/2026-01-drug-combinations-stem-cell-heart.html Wed, 28 Jan 2026 16:57:38 EST news688841821 Can the brain keep working when its architecture changes? Researchers at the University of Geneva (UNIGE) have discovered that neurons located in the wrong place can still carry out their normal function—challenging long-held assumptions about how the brain is organized. Published in Nature Neuroscience, this study reveals an unexpected ability of the brain to adapt. https://medicalxpress.com/news/2026-01-misplaced-neurons-brain-essential-sensory.html Mon, 19 Jan 2026 14:47:54 EST news688056362 Researchers at University College London (UCL) have uncovered a key mechanism that helps the body switch off inflammation—a breakthrough that could lead to new treatments for chronic diseases affecting millions worldwide. https://medicalxpress.com/news/2026-01-scientists-natural-inflammation.html Fri, 16 Jan 2026 05:00:08 EST news687697921 Over the past few decades, advances in hematology have illuminated how a delicate balance between stem cell self-renewal and differentiation sustains healthy blood formation. In myelodysplastic syndrome (MDS), however, this balance collapses, leading to abnormal blood cell development and a heightened risk of progression to acute myeloid leukemia. https://medicalxpress.com/news/2025-12-chromatin-accessibility-reveal-stem-cells.html Sat, 13 Dec 2025 12:10:01 EST news684763287 SereNeuro Therapeutics, a preclinical biotechnology company developing non-opioid pain therapies, has unveiled new data on a novel approach to chronic pain management and joint tissue preservation. The data highlight SN101, a first-in-class induced pluripotent stem cell (iPSC)-derived therapy. https://medicalxpress.com/news/2025-12-opioid-pain-sponge-therapy-chronic.html Fri, 12 Dec 2025 16:10:02 EST news684665542 Ebola (EBOV) and Marburg virus (MARV) are highly lethal viruses that cause severe disease in infected patients by extensively damaging the body. This includes the gastrointestinal tract. Severe diarrhea followed by dehydration is a major cause of death in EBOV and MARV disease patients, yet the role of the intestinal lining (epithelium) in these outcomes remains poorly understood. https://medicalxpress.com/news/2025-12-mini-gut-reveals-ebola-marburg.html Thu, 11 Dec 2025 14:00:10 EST news684676801 A team from the Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER) has developed an innovative technique called PLAMseq (proximity-labeled affinity-purified mass spectrometry plus sequencing) that, for the first time, allows simultaneous analysis of chromatin-associated proteins and their location in the genome in a single experiment. The research is published in the journal Science Advances. https://medicalxpress.com/news/2025-12-insights-sequencing-method-reveals-genome.html Thu, 04 Dec 2025 14:16:16 EST news684080148 In research, induced pluripotent stem (iPS) cells are derived from skin, urine, or blood samples and developed into other cells, like heart tissue, that researchers want to study. Because of the similarities between certain dog and human diseases, canine iPS cells have potential uses in regenerative medicine and drug discovery.　 https://medicalxpress.com/news/2025-11-stem-cell-medium-canine-heart.html Fri, 21 Nov 2025 12:35:03 EST news682950901 Every year, millions of lives are suddenly, swiftly transformed by a stroke, which occurs when a blood vessel traveling towards the brain becomes obstructed, causing neurons to die off. Strokes are among the leading causes of disability in adults, and it is estimated that 1 in 6 people will suffer one at some point in their lives. https://medicalxpress.com/news/2025-11-stem-cell-therapy-regenerate-brain.html Wed, 19 Nov 2025 09:43:06 EST news682767782 Rhythmic electrical activity in the retina (known as pathological oscillations) has been observed in several eye diseases, including congenital stationary night blindness (CSNB) and retinitis pigmentosa (RP). These oscillations interfere with the normal transmission of visual information to the brain, often causing degraded or distorted perception. Although scientists have long known that such oscillations occur in retinal ganglion cells (RGCs), the neurons responsible for sending visual signals to the brain, the cellular mechanism that drives this rhythmic activity has remained elusive. https://medicalxpress.com/news/2025-11-loss-key-visual-channel-triggers.html Tue, 18 Nov 2025 14:06:52 EST news682697208 Researchers at Texas A&M University have uncovered a key element of joint cartilage regrowth, which brings them one step closer to regrowing human limbs. https://medicalxpress.com/news/2025-11-discovery-key-joint-regeneration-regrow.html Wed, 12 Nov 2025 09:10:01 EST news682157724 Every second, millions of blood cells are produced in the human body, and about 90% of the cells replaced daily are blood cells. These include red blood cells essential for oxygen transport, platelets for blood clotting, and immune cells that protect us from infections. Because these cells are short-lived, they must be continuously replenished. https://medicalxpress.com/news/2025-11-blood-stem-cell-diversification-revealed.html Tue, 11 Nov 2025 13:40:02 EST news682090463 Frankenstein's creature is coming back to life—again. As Guillermo del Toro's new adaptation of Mary Shelley's gothic masterpiece airs on Netflix, we provide an anatomist's perspective of her tale of reanimation. Could an assembled body ever breathe, bleed or think? https://medicalxpress.com/news/2025-11-frankenstein-body-anatomists.html Thu, 06 Nov 2025 12:29:04 EST news681654542 If cancer is a disease of overabundance, where cells divide without restraint and tumors grow despite the body's best interests, then degenerative diseases are disorders of deprivation. When malfunctions occur in the biological machinery that our muscles or brains use for renewal and repair, these tissues gradually wither. This kind of decline is the hallmark of diseases such as Alzheimer's disease or Duchenne muscular dystrophy. https://medicalxpress.com/news/2025-10-blocking-key-protein-yield-potency.html Thu, 30 Oct 2025 14:57:04 EDT news681055021 Tooth development is a dynamic process that involves the stages of the bud, the cap, and the bell, followed by root development and subsequent tooth formation. Processes such as the bud-to-cap transition are mediated by epithelial-mesenchymal interactions. In addition, the position of a cell in a developing embryo determines its fate due to the relative differences in concentration of signaling molecules and growth factors. https://medicalxpress.com/news/2025-10-scientists-cells-teeth.html Thu, 23 Oct 2025 13:04:24 EDT news680443458 The body's tissues can get injured in many ways, but while some injuries heal perfectly, others don't heal at all. A cut in the skin, for example, usually heals all on its own, while internal organs, such as the heart after a heart attack or the kidney after an acute injury, remain damaged, leading to diminished function. Most tissues of the body repair themselves using the same processes, but until now, drugs that target these pathways to enhance tissue repair in slow-healing organs have not been identified. That's about to change. https://medicalxpress.com/news/2025-10-fda-heart-tissue-regeneration-drug.html Fri, 10 Oct 2025 10:07:35 EDT news679309649 Thanks to in-utero blood transfusion technology, what was once a fatal diagnosis in the womb can now result in live births. However, this medical advancement created a new challenge: a growing population of children born with that diagnosis—the severe, inherited blood disorder alpha thalassemia—which requires lifelong specialized care. https://medicalxpress.com/news/2025-09-gene-therapy-lifelong-transfusions-rare.html Thu, 18 Sep 2025 11:47:04 EDT news677414821 A USC Stem Cell-led research team has achieved a major step forward in the effort to build mouse and human synthetic kidneys. In a new paper published in Cell Stem Cell, the scientists describe generating more mature and complex lab-grown kidney structures (organoids) than ever before. https://medicalxpress.com/news/2025-09-lab-grown-kidney-maturity-synthetic.html Wed, 17 Sep 2025 11:00:27 EDT news677261221 For a long time, physicians and scientists believed our lungs were sterile (germ-free). But modern science indicates otherwise. Now we know they contain allergens, bacteria or viruses we inhale, such as influenza or SARS-COV-2, the virus that causes COVID-19. When those contaminants combine with inflammation, it can lead to chronic lung disease. https://medicalxpress.com/news/2025-09-il-small-protein-big-pulmonary.html Tue, 16 Sep 2025 16:20:03 EDT news677258401 EPFL scientists have shown that a gene linked to a rare childhood disease is essential for regenerating intestinal stem cells after injury. https://medicalxpress.com/news/2025-09-gene-rare-disorder-crucial-intestinal.html Tue, 09 Sep 2025 14:48:03 EDT news676648081 Scientists at Kumamoto University have made a major breakthrough in regenerative medicine by successfully creating functional ureter tissue—organoids resembling the urinary tract—from pluripotent stem cells. The results, published in Nature Communications, bring researchers one step closer to developing transplantable kidneys capable of producing and expelling urine. https://medicalxpress.com/news/2025-08-functional-ureter-tissue-stem-cells.html Wed, 27 Aug 2025 10:53:52 EDT news675510820 For the first time, a research team at the University of Minnesota Twin Cities demonstrated a process that combines 3D printing, stem cell biology, and lab-grown tissues for spinal cord injury recovery. https://medicalxpress.com/news/2025-08-3d-scaffold-spinal-cord-injury.html Mon, 25 Aug 2025 09:41:04 EDT news675333661 A new study from researchers at the University of Illinois Chicago reveals how the blood-brain barrier gets leakier with age, contributing to memory deficits. The study, published in Cell Reports, uncovered the molecular mechanisms behind this process and could provide new therapeutic targets to address cognitive decline earlier in the aging process. https://medicalxpress.com/news/2025-08-molecular-mechanisms-blood-brain-barrier.html Tue, 12 Aug 2025 14:10:06 EDT news674226601 For more than 30 years, scientists have studied how the myogenic determination gene number 1 (MYOD) protein binds DNA to modify the gene expression of muscle stem cells. Similar to the instant kung fu education Keanu Reeves downloaded in "The Matrix," MYOD plugs into muscle stem cell DNA and reprograms the cells to build muscle. https://medicalxpress.com/news/2025-08-muscle-master-moonlights-gene-silencer.html Mon, 11 Aug 2025 14:29:04 EDT news674141341 A research team at National Taiwan University has developed a new stem cell-based vaccine that could help prevent and treat colorectal cancer. https://medicalxpress.com/news/2025-08-ipsc-based-vaccines-colorectal-cancer.html Tue, 05 Aug 2025 06:00:02 EDT news673592140 Amyotrophic lateral sclerosis (ALS), known as Lou Gehrig's disease, is an incurable neurological disorder affecting motor neurons—nerve cells in the brain and spinal cord that control voluntary muscle movement and breathing. https://medicalxpress.com/news/2025-08-stem-cells-als-patients-potential.html Tue, 05 Aug 2025 05:00:09 EDT news673519861 AI-based medicine will revolutionize care, including for Alzheimer's and diabetes, predicts a technology expert, but it must be accessible to all patients. https://medicalxpress.com/news/2025-08-human-doctors-ai-health-revolution.html Fri, 01 Aug 2025 06:16:29 EDT news673247783 Hematopoietic stem cells (HSCs) are the fundamental building blocks of our circulatory system, giving rise to all blood cell types, including white blood cells, red blood cells, and platelets. HSCs play a key role in our understanding of complex biological processes and are involved in life-saving treatments such as bone marrow transplants and emerging gene therapies. As a cornerstone of regenerative medicine, HSCs hold immense promise for treating blood disorders, cancers, and immune system diseases. https://medicalxpress.com/news/2025-07-blood-stem-cell-quality-behavior.html Tue, 29 Jul 2025 11:26:59 EDT news673007215