https://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. Sepsis is a leading global cause of hospital deaths, occurring when the body's response to infection damages tissue and causes organs to fail. Africa bears the world's highest burden of sepsis, with an estimated 48 million cases each year leading to about 11 million deaths. People living with HIV face the greatest risk of dying from the condition. https://medicalxpress.com/news/2026-02-early-tb-treatment-hiv-sepsis.html Sat, 07 Feb 2026 07:20:01 EST news689663830 Griffith University researchers may have unlocked the secret to treating sepsis, with a Phase II clinical trial in China successfully concluding with promising results. https://medicalxpress.com/news/2026-01-potential-treatment-sepsis.html Thu, 15 Jan 2026 05:23:32 EST news687676981 A University of Virginia-led team of researchers has made a discovery that may change sepsis treatment for patients in Africa. https://medicalxpress.com/news/2026-01-simple-sepsis-treatment-thousands.html Wed, 07 Jan 2026 08:34:32 EST news686997193 New research from Liverpool School of Tropical Medicine (LSTM) has shown gut and bloodstream infections are caused by the same bacteria, giving hope of better prevention and diagnosis of deadly neonatal sepsis. https://medicalxpress.com/news/2025-12-links-gut-bloodstream-infections-newborns.html Wed, 10 Dec 2025 20:20:02 EST news684598831 High BMI and poor physical fitness during later adolescence increase the risk of both contracting and dying from sepsis and other severe bacterial infections in adulthood, according to a study from the University of Gothenburg. https://medicalxpress.com/news/2025-12-high-teenage-bmi-linked-severe.html Tue, 09 Dec 2025 11:34:30 EST news684502362 Immunotherapy for sepsis is effective when doctors tailor the treatment precisely to the patient's immune system condition. While earlier research showed little benefit of immunotherapy in sepsis, a new study demonstrates that a targeted approach of immunotherapy does improve clinical outcomes. This is reported by a consortium of 33 hospitals in JAMA, led by Radboud university medical center and the Hellenic Institute for the Study of Sepsis. https://medicalxpress.com/news/2025-12-immunotherapy-sepsis-precision-approach.html Mon, 08 Dec 2025 11:00:04 EST news684158738 A multi-country clinical trial has shown that a structured, sustainable approach to infection prevention and treatment can save women's lives, cutting severe maternal infections and deaths by about one-third (32%) compared to usual care. The maternal program of prevention and treatment (APT-Sepsis) was developed by researchers at the University of Liverpool, the World Health Organization (WHO) and the UN's Special Program in Human Reproduction (HRP). https://medicalxpress.com/news/2025-11-maternal-health-infection-deaths-large.html Wed, 19 Nov 2025 17:00:01 EST news682791781 A new discovery from the lab of YouYang Zhao, Ph.D., from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago, opens promising new directions for treatment of life-threatening lung injury caused by sepsis. https://medicalxpress.com/news/2025-11-potential-gene-based-treatment-sepsis.html Mon, 17 Nov 2025 14:34:04 EST news682612442 While our immune systems typically do a great job containing pathogens and clearing infections, they can occasionally overreact. When the immune response to infection becomes excessive, it causes rapid, widespread organ damage in a life-threatening condition called sepsis. Worldwide, sepsis imposes significant social, economic, and health costs. Estimates put global cases of sepsis at 50 million per year, resulting in over 11 million deaths annually. https://medicalxpress.com/news/2025-10-moderate-dose-corticosteroid-treatment-patient.html Thu, 16 Oct 2025 16:00:01 EDT news679849104 Using medical data from sick patients while they're still at home, traveling in an ambulance and receiving care in the emergency room, researchers at Northeastern have used artificial intelligence to build a tool that predicts life-threatening septic shock with 99% accuracy. https://medicalxpress.com/news/2025-10-ai-sepsis-accuracy-life-threatening.html Thu, 16 Oct 2025 10:12:04 EDT news679828322 Sepsis remains one of the leading causes of mortality in hospitalized patients worldwide, and innovative therapeutic strategies are urgently needed. https://medicalxpress.com/news/2025-10-based-therapy-treatment-sepsis-brazilian.html Wed, 15 Oct 2025 16:47:02 EDT news679765621 Sepsis, or infection causing life-threatening organ dysfunction, is a leading cause of death in children worldwide. In efforts to prevent this rare but critical condition, researchers developed and validated AI models that accurately identify children at high risk for sepsis within 48 hours, so that early preemptive care can be provided. https://medicalxpress.com/news/2025-10-ai-sepsis-children-preemptive.html Mon, 13 Oct 2025 11:00:08 EDT news679304281 In an advance for critical care medicine, two international studies published in parallel in the journal Nature Medicine have established a new unified framework for understanding the biological chaos of sepsis and other life-threatening illnesses. A University of Malta researcher, Dr. Brendon Scicluna of the Department of Applied Biomedical Science, Faculty of Health Sciences, designed and spearheaded one of the studies and made significant contributions to the second, placing the University at the forefront of the global effort to bring precision medicine to the sickest patients in our hospitals. https://medicalxpress.com/news/2025-10-global-standard-precision-medicine-sepsis.html Mon, 06 Oct 2025 14:43:04 EDT news678980581 Living with type 2 diabetes (T2D) may double the risk of developing sepsis—with those aged younger than 60 years and men particularly susceptible, according to a long-term community-based study in Australia, being presented at this year's Annual Meeting of the European Association for the Study of Diabetes (EASD), Vienna (15–19 Sept). https://medicalxpress.com/news/2025-09-diabetes-sepsis-large-community-based.html Mon, 15 Sep 2025 18:00:01 EDT news677173002 On World Sepsis Day, health experts remind Americans that sepsis strikes 1.7 million people in the U.S. each year and causes more than 350,000 deaths. https://medicalxpress.com/news/2025-09-world-sepsis-day-doctors-urge.html Mon, 15 Sep 2025 10:10:02 EDT news677146888 A team of University of Saskatchewan (USask) researchers have identified a pathway to help the human body defend itself against sepsis—a life-threatening condition caused by the body's inappropriate response to an infection. https://medicalxpress.com/news/2025-09-method-sepsis.html Mon, 15 Sep 2025 08:58:04 EDT news677145481 Sepsis arises from infection and immune dysregulation. Neutrophils play a key role in its progression, yet existing clinical tools cannot simultaneously isolate these cells and measure their functional activity. https://medicalxpress.com/news/2025-09-microfluidic-platform-free-neutrophil-function.html Fri, 05 Sep 2025 13:08:13 EDT news676296488 A recent University of Michigan-led study finds that 10% of patients hospitalized with sepsis were previously healthy—and many of those who ultimately died did so because it was too late to intervene. https://medicalxpress.com/news/2025-08-sepsis-previously-healthy-people-late.html Wed, 20 Aug 2025 15:30:16 EDT news674922606 Scientists at the University of Virginia School of Medicine and the University of Michigan have developed a monoclonal antibody to stop sepsis, a deadly full-body infection. The antibody also has the potential to treat a broad array of other inflammatory conditions, including autoimmune disorders, their research indicates. https://medicalxpress.com/news/2025-08-monoclonal-antibody-deadly-sepsis-cytokine.html Thu, 14 Aug 2025 14:34:05 EDT news674400841 There are relatively large regional differences in Sweden in the proportion of newborns receiving antibiotics for suspected sepsis, according to a study from the University of Gothenburg. The researchers want to call attention to overuse as well as highlight good examples. https://medicalxpress.com/news/2025-08-wide-regional-gaps-newborn-antibiotic.html Mon, 04 Aug 2025 08:20:01 EDT news673513817 Scientists in Ghent have achieved a breakthrough in sepsis research. In a study on mice, the researchers demonstrated that vitamin B1 (thiamine pyrophosphate, TPP) restores mitochondrial energy metabolism, drastically reduces lactate production, and increases survival rates in sepsis. The study results are published in Cell Reports. https://medicalxpress.com/news/2025-07-vitamin-b1-deadly-lactate-production.html Tue, 29 Jul 2025 08:39:04 EDT news672997141 More accurate measures are needed to help diagnose children with sepsis as a current clinical tool is failing to detect those requiring hospital care, according to a new study. https://medicalxpress.com/news/2025-07-accurate-required-sepsis-children.html Wed, 23 Jul 2025 06:30:03 EDT news672470920 Early-onset neonatal sepsis and meningitis are associated with an increased risk for childhood epilepsy, according to a study published online July 7 in JAMA Network Open. https://medicalxpress.com/news/2025-07-early-onset-neonatal-sepsis-linked.html Fri, 11 Jul 2025 12:52:12 EDT news671457129 Early-onset neonatal sepsis is associated with an increased likelihood of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), although the association with ADHD is attenuated in sibling-matched analyses, according to a study published online June 18 in Paediatric and Perinatal Epidemiology. https://medicalxpress.com/news/2025-06-onset-sepsis-week-life-likelihood.html Tue, 24 Jun 2025 17:20:02 EDT news670000794 Scientists from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago and colleagues identified several proteins from the umbilical cord blood of preterm newborns that signal acute systemic inflammation as an immune response to infection, providing objective and noninvasive means to diagnose early onset sepsis. https://medicalxpress.com/news/2025-06-umbilical-cord-blood-biomarkers-early.html Fri, 20 Jun 2025 12:50:03 EDT news669642139 Sepsis is when the immune system overshoots its inflammatory reaction to an infection, so strongly that the vital organs begin to shut down. It is life-threatening: each year in the US alone, approximately 750,000 patients are hospitalized for sepsis, of which approximately 27% die. https://medicalxpress.com/news/2025-06-statins-death-patients-life-threatening.html Fri, 06 Jun 2025 00:00:02 EDT news668331444 Canadian scientists have developed a blood test and portable device that can determine the onset of sepsis faster and more accurately than existing methods. https://medicalxpress.com/news/2025-05-rapid-bedside-sepsis-accuracy.html Tue, 27 May 2025 12:42:04 EDT news667568522 Sepsis is a life-threatening condition triggered by the body's extreme response to infection. It causes widespread inflammation, which can lead to tissue damage, organ failure and death. https://medicalxpress.com/news/2025-05-sepsis-syndrome-body-recovers-brain.html Thu, 15 May 2025 09:26:04 EDT news666519961 When the immune system does not function properly, individuals become more susceptible to infections caused by viruses, bacteria, or fungi. Researchers from Radboud University Medical Center have demonstrated that an existing drug can revive immune cells that are not functioning correctly. These findings provide leads for further research in patients admitted to the intensive care unit (ICU) with sepsis. https://medicalxpress.com/news/2025-04-drug-revive-immune-cells-sepsis.html Fri, 18 Apr 2025 07:00:01 EDT news664112845 A study presented at ESCMID Global 2025 has uncovered the potential of interleukin-6 (IL-6) as a powerful diagnostic biomarker for the early detection of sepsis in high-risk patient groups, including neonates, children and pregnant women. This study is the first to evaluate IL-6's diagnostic performance in a real-world cohort across all three populations. https://medicalxpress.com/news/2025-04-biomarker-early-sepsis-neonates-children.html Fri, 11 Apr 2025 18:10:06 EDT news663585541