The impact of cohesin mutations: Insights into a hidden regulator of alternative splicing in leukemia
A new role for cohesin in regulating alternative splicing has been identified, providing insights into splicing mutations in human disease.
A new role for cohesin in regulating alternative splicing has been identified, providing insights into splicing mutations in human disease.
A study led by researchers at the UC San Diego Stem Cell Research program and funded by the California Institute for Regenerative Medicine (CIRM) looks at an important RNA binding protein called LIN28, which is implicated ...
Sep 4, 2012
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Italian scientists from Università Cattolica at Rome have discovered an important genetic mechanism that pancreatic cancer cells employ to evade therapies, paving the way to new drugs for a killer disease. The tumor evades ...
Feb 6, 2024
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Pancreatic cancer presents a challenging prognosis, marked by a five-year overall survival rate of merely 12.5%. Diagnosis frequently occurs at an advanced stage, characterized by metastasis to distant sites. The intricate ...
Jan 11, 2024
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UCLA-led research describes the role that a protein called CEACAM1 plays in protecting the liver from injury during the transplantation process, potentially improving transplant outcomes. But the features that regulate this ...
Aug 2, 2023
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Researchers at Children's Hospital of Philadelphia (CHOP) and the University of California, Los Angeles (UCLA) have developed a computational platform capable of discovering tumor antigens derived from alternative RNA splicing, ...
May 17, 2023
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Living organisms have a knack for persisting in the face of challenges. For instance, when genes malfunction, organisms may be able to compensate by activating redundant genes with similar functions, called paralogs.
Feb 21, 2023
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When cells copy DNA to produce RNA transcripts, they include only some chunks of genetic material known as exons and throw out the rest. The resulting product is a fully-mature RNA molecule, which can be used as a template ...
Feb 9, 2023
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Researchers from Barts Cancer Institute (BCI) at Queen Mary University of London, the Italian Institute for Genomic Medicine, and the University of Milan have identified a novel role for a cancer-causing gene in controlling ...
Sep 27, 2022
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Currently, there is no cure for amyotrophic lateral sclerosis (ALS). Things could soon change, however. Researchers at FAU and the University of California San Diego (UCSD) have identified a protein that already displays ...
Jul 19, 2022
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