Desomorphine has been in the news lately. Never heard of it? That's quite possible. But you may well have heard its street name: "Krokodil." However you know it, it's a cheap substitute for heroin that has been widely branded ...
Nov 6, 2018
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A newly identified protein can be manipulated to make opioid painkillers effective at lower doses while also muting the reward mechanism that leads to addiction, Mount Sinai researchers have found.
Feb 12, 2018
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(Medical Xpress) -- Morphine's analgesic properties are as potent as its addictive potential are problematic. The neural pathway for that addiction is typically associated with dopamine (DA) neurons of the ventral tegmental ...
By the end of 2019, 39 states had enacted limits restricting prescriptions for opioid analgesics, according to new data released today by the Center for Public Health Law Research at Temple University's Beasley School of ...
Sep 15, 2022
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A new study conducted at the RI-MUHC concludes that prescribing opioid analgesics at discharge after surgery does not reduce postoperative pain and increases the risk of adverse events.
Jun 20, 2022
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Despite nearly 60 years of research, there is still a lack of high-certainty evidence on the effectiveness and safety of commonly used painkillers (analgesics) for short bouts of low back pain, finds an analysis of the evidence ...
Mar 22, 2023
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A retrospective case series study led by Dr. Vinod Dasa, Professor of Clinical Orthopaedics at LSU Health New Orleans School of Medicine, reports that more than two-thirds of the patients who underwent total knee replacement ...
Mar 25, 2022
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Researchers from Columbia University Medical Center (CUMC) found that men had greater pain relief than women after smoking marijuana.
Aug 18, 2016
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Global opioid sales increased by an estimated 4% annually from 2015 to 2019, but massive disparities in access to essential pain relief medications persist between countries, finds a study led by UCL researchers.
Mar 30, 2022
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Co-prescription of the anticonvulsant gabapentin is associated with an increased risk of opioid-related death in people who are prescribed opioid painkillers, according to a new study published in PLOS Medicine.
Oct 3, 2017
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An analgesic (also known as a painkiller) is any member of the group of drugs used to relieve pain (achieve analgesia). The word analgesic derives from Greek an- ("without") and algos ("pain").
Analgesic drugs act in various ways on the peripheral and central nervous systems; they include paracetamol (para-acetylaminophenol, also known in the US as acetaminophen), the non-steroidal anti-inflammatory drugs (NSAIDs) such as the salicylates, and opioid drugs such as morphine and opium. They are distinct from anesthetics, which reversibly eliminate sensation.
In choosing analgesics, the severity and response to other medication determines the choice of agent; the WHO pain ladder, originally developed in cancer-related pain, is widely applied to find suitable drugs in a stepwise manner. The analgesic choice is also determined by the type of pain: for neuropathic pain, traditional analgesics are less effective, and there is often benefit from classes of drugs that are not normally considered analgesics, such as tricyclic antidepressants and anticonvulsants.
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