Alzheimer's disease & dementia

Racial disparities in drug prescriptions for dementia

Disparities in drug prescribing suggest that black and Asian people with dementia are not receiving the same quality of care as their white peers, according to a new UCL-led study in the UK.

Psychology & Psychiatry

Long-term medication for schizophrenia is safe

Researchers at Karolinska Institutet in Sweden and their colleagues in Germany, the U.S. and Finland have studied the safety of very long-term antipsychotic therapy for schizophrenia. According to the study, which is published ...

Alzheimer's disease & dementia

More hospital days seen with antipsychotic use in Alzheimer disease

(HealthDay)—Alzheimer disease patients who initiate treatment with antipsychotic medications spend more days hospitalized than those who do not initiate antipsychotics, according to a study recently published in the Journal ...

Psychology & Psychiatry

For young people with psychosis, early intervention is crucial

Andrew Echeguren, 26, had his first psychotic episode when he was 15. He was working as an assistant coach at a summer soccer camp for kids when the lyrics coming out of his iPod suddenly morphed into racist and homophobic ...

page 1 from 22

Antipsychotic

An antipsychotic (or neuroleptic) is a tranquilizing psychiatric medication primarily used to manage psychosis (including delusions or hallucinations, as well as disordered thought), particularly in schizophrenia and bipolar disorder. A first generation of antipsychotics, known as typical antipsychotics, was discovered in the 1950s. Most of the drugs in the second generation, known as atypical antipsychotics, have been developed more recently, although the first atypical antipsychotic, clozapine, was discovered in the 1950s and introduced clinically in the 1970s. Both generations of medication tend to block receptors in the brain's dopamine pathways, but antipsychotic drugs encompass a wide range of receptor targets.

A number of harmful and undesired (adverse) effects have been observed, including lowered life expectancy, weight gain, decrease in brain volume, enlarged breasts and milk discharge in men and women (hyperprolactinaemia), lowered white blood cell count (agranulocytosis), involuntary repetitive body movements (tardive dyskinesia), diabetes, an inability to sit still or remain motionless (akathisia), sexual dysfunction, a return of psychosis requiring increasing the dosage due to cells producing more neurochemicals to compensate for the drugs (tardive psychosis), and a potential for permanent chemical dependence leading to psychosis much worse than before treatment began, if the drug dosage is ever lowered or stopped (tardive dysphrenia).[citation needed]

Temporary withdrawal symptoms including insomnia, agitation, psychosis, and motor disorders may occur during dosage reduction of antipsychotics, and can be mistaken for a return of the underlying condition.

The development of new antipsychotics with fewer of these adverse effects and with greater relative effectiveness as compared to existing antipsychotics (efficacy), is an ongoing field of research.

This text uses material from Wikipedia, licensed under CC BY-SA