Alzheimer's disease & dementia

Experimental Alzheimer's drug improves memory in mice

An experimental drug known as A03, which was previously developed to treat depression, increases the levels of the enzyme Sirtuin1, or SirT1, and improves memory in mice. The mice were genetically modified to have a protein ...

Alzheimer's disease & dementia

Major Alzheimer's risk factor linked to red wine target

The major genetic risk factor for Alzheimer's disease (AD), present in about two-thirds of people who develop the disease, is ApoE4, the cholesterol-carrying protein that about a quarter of us are born with. But one of the ...

Alzheimer's disease & dementia

ApoE4 Alzheimer's gene causes brain's blood vessels to leak, die

Common variants of the ApoE gene are strongly associated with the risk of developing late-onset Alzheimer's disease, but the gene's role in the disease has been unclear. Now, researchers funded by the National Institutes ...

Alzheimer's disease & dementia

Study clarifies ApoE4's role in dementia

ApoE4, a protein linked to both Alzheimer's disease and a form of dementia caused by damage of blood vessels in the brain, increases the risk of cognitive impairment by reducing the number and responsiveness of blood vessels ...

Alzheimer's disease & dementia

Neuroscientists discover roles of gene linked to Alzheimer's

People with a gene variant called APOE4 have a higher risk of developing late-onset Alzheimer's disease: APOE4 is three times more common among Alzheimer's patients than it is among the general population. However, little ...

Alzheimer's disease & dementia

Study links aortic stiffness with lower cerebral blood flow

Greater aortic stiffness is related to lower cerebral blood flow, especially among individuals with increased genetic predisposition to Alzheimer's disease, according to research from Vanderbilt University Medical Center.

Alzheimer's disease & dementia

Testing for Alzheimer's genes forces difficult decisions

Last year, Barbara's husband thought it would be fun to learn more about their family's history, so he bought 23andMe gene-testing kits for himself, Barbara and their three daughters for Christmas.

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