Oncology & Cancer

Predicting resistance to anticancer drugs

Cancer cells can develop resistance to therapy through both genetic and non-genetic mechanisms. But it is unclear how and why one of these routes to resistance prevails. Understanding this 'choice' by the cancer cells may ...

Oncology & Cancer

Identifying new targeted therapy approaches for leukemia

A team of Northwestern Medicine scientists led by Ali Shilatifard, Ph.D., the Robert Francis Furchgott Professor and chair of Biochemistry and Molecular Genetics, has identified the molecular mechanisms of ASXL1 mutations ...

Medical research

Transporter imbalance implicated in schizophrenia

Alterations in the balance of two chloride ion transporters may be responsible for cognitive deficits in schizophrenia, according to a Northwestern Medicine study published in Science Advances.

Oncology & Cancer

New computational method detects disrupted pathways in cancer

Cancer is a notoriously complex disease, in part because it may be caused by mutations among hundreds or even thousands of genes. In addition, most cancers exhibit an extraordinary amount of variation among genetic mutations, ...

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