Inflammatory disorders

Potential new therapy for Crohn's, colitis identified

People with inflammatory bowel disease (IBD) live with frequent, miserable episodes of abdominal pain, diarrhea and in severe cases, rectal bleeding. Standard treatments are aimed at directly suppressing inflammation, but ...

Immunology

New immunotherapy targeting blood-clotting protein

Normally, the blood protein fibrin does not enter the brain. But in several neurological disorders, the blood-brain barrier—which keeps large molecules in the blood from entering the brain—becomes abnormally permeable, ...

Immunology

Mechanism behind autoimmune disorder revealed

Northwestern Medicine scientists discovered a previously-unknown mechanism of disease behind a specific autoimmune disorder, findings published in the Proceedings of the National Academy of Sciences.

Medical research

New methods reveal the biomechanics of blood clotting

Platelets are cells in the blood whose job is to stop bleeding by sticking together to form clots and plug up a wound. Now, for the first time, scientists have measured and mapped the key molecular forces on platelets that ...

Diseases, Conditions, Syndromes

Blocking gene expression improves outcomes in blood disease in models

Scientists successfully reduced the symptoms of a blood disease called myeloproliferative neoplasm in mouse models by interrupting an important regulatory pathway, according to a Northwestern Medicine study published in the ...

Cardiology

How and why blood clots shrink

Blood clotting is the "Jekyll and Hyde" of biological processes. It's a lifesaver when you're bleeding, but gone awry, it causes heart attacks, strokes and other serious medical problems. If a clot grows too big, pieces dislodged ...

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