Diseases, Conditions, Syndromes

New osteoporosis therapy's dual effects on bone tissue

Sclerostin is a protein produced by osteocytes in the bone that inhibits bone formation. A recent analysis of results from a clinical trial reveals the beneficial effects of romosozumab, an antibody therapy that targets sclerostin, ...

Gerontology & Geriatrics

Individualized therapy for patients with osteoporosis

More than six million people in Germany suffer from osteoporosis. The disease is characterized by chronic bone resorption, leading to frequent fractures as a consequence of the bone loss. In many cases, treating the condition ...

Diseases, Conditions, Syndromes

New mechanism activates bone-building cells in osteoperosis

The number of osteoporosis medications that promote bone formation are few compared to those that suppress bone resorption. A research group led by Kumamoto University scientists has discovered that the gene SIRT7 is important ...

Medical research

Clarifying the interplay between bone cells in bone remodeling

Bones have numerous functions, including providing mechanical support of soft tissues, acting as levers for muscle action, and protecting the central nervous system. To accomplish their functions, bones undergo continuous ...

Arthritis & Rheumatism

Jawbone loss predates rheumatoid arthritis

Jawbone loss caused by periodontitis predates the onset of rheumatoid arthritis. This according to research from UmeƄ University in Sweden presented in the journal Arthritis & Rheumatology. The research also shows a causal ...

Medical research

Link between cells associated with aging and bone loss

Mayo Clinic researchers have reported a causal link between senescent cells - the cells associated with aging and age-related disease - and bone loss in mice. Targeting these cells led to an increase in bone mass and strength. ...

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