Oncology & Cancer
Simpler name for cancer genetic syndrome could save lives
As medical science links certain genetic mutations with a greater variety of cancers, the names for these risk syndromes are falling out of step.
Jul 4, 2019
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News tagged with brca2
Oncology & Cancer
Drug target identified for chemotherapy-resistant ovarian, breast cancer
People who inherit a faulty copy of the so-called "breast cancer genes" BRCA1 and BRCA2 are at high risk of cancer. About 10 percent of breast cancer cases and 15 percent of ovarian cancers can be traced back to a flaw in ...
Feb 4, 2019
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Oncology & Cancer
New drug targets for BRCA-driven cancer uncovered
BRCA1 and BRCA2 ("BReast CAncer genes") are critical tumor suppressor genes—women carrying a mutation in one of these genes have up to an 80 percent risk of developing breast cancer and a 50 percent risk of developing ovarian ...
Jan 24, 2019
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Oncology & Cancer
The long and short of CDK12
Mutations in the BRCA1 and BRCA2 genes pose a serious risk for breast and ovarian cancer because they endanger the genomic stability of a cell by interfering with homologous recombination repair (HR), a key mechanism for ...
Dec 3, 2018
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Genetics
Mystery of breast cancer risk gene solved, 20 years after its discovery
More than 20 years after scientists revealed that mutations in the BRCA1 gene predispose women to breast cancer, Yale scientists have pinpointed the molecular mechanism that allows those mutations to wreak their havoc.
Oct 4, 2017
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Oncology & Cancer
Searching for the 'signature' causes of BRCAness in breast cancer
Breast cancer cells with defects in the DNA damage repair-genes BRCA1 and BRCA2 have a mutational signature (a pattern of base swaps—e.g., Ts for Gs, Cs for As—throughout a genome) known in cancer genomics as "Signature ...
Aug 21, 2017
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Oncology & Cancer
Common class of chemicals cause cancer by breaking down DNA repair mechanisms
A common class of chemicals found everywhere from car exhausts, smoke, building materials and furniture to cosmetics and shampoos could increase cancer risk because of their ability to break down the repair mechanisms that ...
Jun 1, 2017
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Oncology & Cancer
Gene increases risk of breast cancer to one in three by age 70
Breast cancer risks for one of potentially the most important genes associated with breast cancer after the BRCA1/2 genes are today reported in the New England Journal of Medicine. Women with mutations in the PALB2 gene have ...
Aug 6, 2014
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Oncology & Cancer
Study links another gene variant to male breast cancer
(HealthDay)—Researchers report that they've identified another genetic variation that appears connected to male breast cancer, a rare condition that kills several hundred men in the United States each year.
Sep 23, 2012
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Oncology & Cancer
Diagnostic chest radiation before 30 may increase breast cancer risk
Women carrying a mutation in the BRCA1- or BRCA2- genes (which control the suppression of breast and ovarian cancer) who have undergone diagnostic radiation to the chest before the age of 30 are more likely to develop breast ...
Sep 6, 2012
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BRCA2
More reference expression data
BRCA2 (Breast Cancer Type 2 susceptibility protein) is a protein that in humans is encoded by the BRCA2 gene. BRCA2 belongs to the tumor suppressor gene family and the protein encoded by this gene is involved in the repair of chromosomal damage with an important role in the error-free repair of DNA double strand breaks.
The BRCA2 gene is located on the long (q) arm of chromosome 13 at position 12.3 (13q12.3), from base pair 31,787,616 to base pair 31,871,804.
This text uses material from Wikipedia, licensed under CC BY-SA
