Genetics

Mutant gene-targeted immunotherapy approach developed

A novel targeted immunotherapy approach developed by researchers at the Ludwig Center, the Lustgarten Laboratory, and Bloomberg-Kimmel Institute for Cancer Immunotherapy at the Johns Hopkins Kimmel Cancer Center employs new ...

Immunology

Second 'don't eat me' signal found on cancer cells

A second biological pathway that signals immune cells not to engulf and kill cancer cells has been identified by researchers at the Stanford University School of Medicine.

Oncology & Cancer

Personalized melanoma vaccines marshal powerful immune response

Personalized melanoma vaccines can be used to marshal a powerful immune response against unique mutations in patients' tumors, according to early data in a first-in-people clinical trial at Washington University School of ...

Oncology & Cancer

Older patients benefit from cancer immunotherapies

A retrospective analysis of large datasets of biomarkers from tumors and healthy tissue by researchers at the Johns Hopkins Kimmel Cancer Center Convergence Institute suggests that older cancer patients could benefit as ...

Oncology & Cancer

'Tumor avatars' predict patients' response to immunotherapy

Tumor fragments in the lab are able to predict whether the corresponding real-life patients will benefit from immunotherapy. "We've solved a major problem many scientists had been facing: Preserving a tumor's original composition ...

Medical research

Common tumor inhibitor drug triggers unfavorable immune effects

Cancer immunotherapy involving drugs that inhibit CTLA-4 also activates an unwanted response that may self-limit its efficacy in fighting tumors, according to a new study led by Francesco Marangoni, Ph.D., assistant professor ...

Oncology & Cancer

Combining immunotherapies against cancer

A new cancer vaccine could boost the positive effects of existing immunotherapy drugs, improving the success rate of treatments from 20% to 75% of cases, according to a new study by immunologists from the University of Konstanz. ...

Medical research

Mitochondria could boost immunotherapy effectiveness

Boosting mitochondrial function in a subpopulation of T cells could make cancer immunotherapy more effective, according to a recent study published in the Proceedings of the National Academy of Sciences (PNAS).

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