Medical research

Cannabinoids control memory through mitochondria

(Medical Xpress)—Few classes of drugs have galvanized the pharmaceutical industry in recent times like the cannabinoids. This class of molecules includes not only the natural forms, but also a vast new treasury of powerful ...

Neuroscience

Team discovers potential new way to treat anxiety

Chemically modified inhibitors of the COX-2 enzyme relieve anxiety behaviors in mice by activating natural "endocannabinoids" without gastrointestinal side effects, Vanderbilt University scientists will report next week.

Neuroscience

Breakthrough discovery in neurotransmission

Samir Haj-Dahmane, Ph.D., senior research scientist at the University at Buffalo Research Institute on Addictions, has discovered how certain neurotransmitters are transported and reach their targets in the brain, which could ...

Medications

Non-psychotropic cannabinoids show promise for pain relief

Some cancers love bone. They thrive in its nutrient-rich environment while gnawing away at the very substrate that sustains them, all the while releasing inflammatory substances that cause pain—pain so severe that opioids ...

Medical research

Omega-3 fatty acids fight inflammation via cannabinoids

Chemical compounds called cannabinoids are found in marijuana and also are produced naturally in the body from omega-3 fatty acids. A well-known cannabinoid in marijuana, tetrahydrocannabinol, is responsible for some of its ...

Psychology & Psychiatry

Study finds natural chemical helps brain adapt to stress

A natural signaling molecule that activates cannabinoid receptors in the brain plays a critical role in stress-resilience—the ability to adapt to repeated and acute exposures to traumatic stress, according to researchers ...

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Cannabinoid

Cannabinoids are a class of chemical compounds which include the phytocannabinoids (oxygen-containing C21 aromatic hydrocarbon compounds found in the cannabis plant), and chemical compounds which mimic the actions of phytocannabinoids or have a similar structure (e.g. endocannabinoids, found in the nervous and immune systems of animals and that activate cannabinoid receptors). The most notable of the cannabinoids is ∆9-tetrahydrocannabinol (THC)—the primary psychoactive compound of cannabis.

Synthetic cannabinoids encompass a variety of distinct chemical classes: the classical cannabinoids structurally related to THC, the nonclassical cannabinoids including the aminoalkylindoles, 1,5-diarylpyrazoles, quinolines and arylsulphonamides, as well as eicosanoids related to the endocannabinoids.

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