Overweight & Obesity

The role of a single molecule in obesity

A single cholesterol-derived molecule, called 27-hydroxycholesterol (27HC), lurks inside your bloodstream and will increase your body fat, even if you don't eat a diet filled with red meat and fried food. That kind of diet, ...

Medical research

Preventing tumor metastasis

Researchers at the Paul Scherrer Institute, together with colleagues from the pharmaceutical company F. Hoffmann-La Roche AG, have taken an important step toward the development of an agent against the metastasis of certain ...

Oncology & Cancer

Super-powered immune cells

The phase 1 clinical trial will test the feasibility and safety of CAR-T cells—genetically modified white blood cells harvested from a patient's own blood with the unique ability to directly attack and kill cancers—to ...

Oncology & Cancer

Study finds new pathway for potential glioblastoma treatment

A team led by Texas A&M University's College of Veterinary Medicine & Biomedical Sciences' (CVM) researcher Dr. Stephen Safe has discovered a new pathway that may help suppress the development of glioblastoma tumors, one ...

Immunology

It's Fab! A hidden touch of antibody

In our immune system, antibodies recognize viruses, bacteria and even cancer cells through their Fab arms, initiating recruitment of leucocytes for the destruction of these invaders. The recruitment is mediated by receptors ...

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Receptor (biochemistry)

In biochemistry, a receptor is a protein molecule, embedded in either the plasma membrane or cytoplasm of a cell, to which a mobile signaling (or "signal") molecule may attach. A molecule which binds to a receptor is called a "ligand," and may be a peptide (such as a neurotransmitter), a hormone, a pharmaceutical drug, or a toxin, and when such binding occurs, the receptor undergoes a conformational change which ordinarily initiates a cellular response. However, some ligands merely block receptors without inducing any response (e.g. antagonists). Ligand-induced changes in receptors result in physiological changes which constitute the biological activity of the ligands.

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