Oncology & Cancer

Combination therapy overcomes BET inhibitor resistance, shows study

Scientists at St. Jude Children's Research Hospital developed a novel combination therapy approach for a leukemia subtype harboring rearrangements in the KMT2A gene. The approach overcomes the cancer's drug resistance, without ...

Gastroenterology

Two-organ chip developed to answer fatty liver questions

A new chip that holds different cell types in tiny, interconnected chambers could allow scientists to better understand the physiological and disease interactions between organs. The integrated-gut-liver-on-a-chip (iGLC) ...

Oncology & Cancer

Alternative glucose breakdown ensures the survival of cancer cells

A key enzyme in sugar metabolism is inactivated particularly easily and efficiently by oxidative stress. Scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now shown that with this ...

Oncology & Cancer

Tool targets cancer-causing fusions' weak spot

Scientists at St. Jude Children's Research Hospital comprehensively characterized oncogenic fusions in pediatric cancer, providing proof-of-principle for genetic engineering-based therapies.

Medications

CBD shows promise for reducing cigarette smoking

Cannabidiol or CBD, a non-psychoactive component of cannabis, inhibits the metabolism of nicotine, new research has found, meaning it could help tobacco users curb the urge for that next cigarette.

Medications

Researchers use a new approach to hit an 'undruggable' target

The protein STAT5 has long been an appealing target against cancer, but after decades of research it was consigned to the "undruggable" category. Now, University of Michigan Rogel Cancer Center researchers have found success ...

page 5 from 40