Oncology & Cancer

Researchers discover key protein in endometrial cancer growth

The hormone estrogen plays many critical roles in men and women, in both healthy tissues and in cancer. In breast and gynecologic cancers, estrogen sends signals to tumors instructing the cancer cells to grow out of control. ...

Oncology & Cancer

Combined drug treatment for lung cancer and secondary tumors

Researchers at Kanazawa University report in the Journal of Thoracic Oncology a promising novel approach for a combined treatment of the most common type of lung cancer and associated secondary cancers in the central nervous ...

Neuroscience

'Chemical earmuffs' could prevent hearing loss

Once you start to lose your hearing, you can't get it back. But what if you could prevent hearing loss by blocking in advance the effects of loud noises?

Obstetrics & gynaecology

Designing an emergency stop switch for immunotherapies

Immunotherapy, unlike chemotherapy and radiotherapy, arms the body's immune system to attack cancer cells. In recent years, it has proven to be remarkably successful at treating leukemia, lymphoma and other liquid cancers, ...

Medical research

Unanticipated response to estrogen at the single cell level

A team led by researchers at Baylor College of Medicine found that not only do individual mammalian cells in a population fail to respond synchronously to estrogen stimulation, neither do individual gene copies, known as ...

Medical research

New opportunity for cancer drug development

After years of research on cell surface receptors called Frizzleds, researchers at Karolinska Institutet in Sweden provide the proof-of-principle that these receptors are druggable by small molecules. The results, which are ...

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Receptor (biochemistry)

In biochemistry, a receptor is a protein molecule, embedded in either the plasma membrane or cytoplasm of a cell, to which a mobile signaling (or "signal") molecule may attach. A molecule which binds to a receptor is called a "ligand," and may be a peptide (such as a neurotransmitter), a hormone, a pharmaceutical drug, or a toxin, and when such binding occurs, the receptor undergoes a conformational change which ordinarily initiates a cellular response. However, some ligands merely block receptors without inducing any response (e.g. antagonists). Ligand-induced changes in receptors result in physiological changes which constitute the biological activity of the ligands.

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