Researchers at UT Southwestern Medical Center have identified a previously unknown role of a cellular signaling molecule involved in release of the "hunger hormone" ghrelin, a finding that could have implications for optimal ...
Aug 22, 2016
0
2
Reprogramming of the molecular pathways underlying normal metabolism is essential for T cell infection-fighting function and for the immune system to form a "memory" of the microbes it has already encountered. But exactly ...
Aug 2, 2016
0
2
Multiple sclerosis (MS) is an autoimmune disorder that results in demyelination of neurons. The FDA-approved drug fingolimod (Gilenya, FTY-720) modulates signaling by the bioactive lipid sphingosine-1-phosphate (S1P), which ...
Jun 16, 2016
0
0
When the body is fighting an invading pathogen, white blood cells—including T cells—must respond. Now, Salk Institute researchers have imaged how vital receptors on the surface of T cells bundle together when activated.
Jun 15, 2016
0
151
The next generation of drugs to tackle two of the planet's biggest killers are to be developed through a partnership bringing together powerful Nobel Prizewinning imaging technology and some of the brightest scientific ...
May 12, 2016
0
1
About thirty percent of all medical drugs such as beta-blockers or antidepressants interact with certain types of cell surface proteins called G protein coupled receptors. In collaboration with researchers from the Paul Scherrer ...
Feb 3, 2016
0
28
T cells are the guardians of our bodies: they constantly search for harmful invaders and diseased cells, ready to swarm and kill off any threats. A better understanding of these watchful sentries could allow scientists to ...
Aug 3, 2015
0
132
A naturally occurring bioluminescent protein found in deep sea shrimp—which helps the crustacean spit a glowing cloud at predators—has been touted as a game-changer in terms of monitoring the way drugs interact with live ...
Jul 7, 2015
0
79
An international research team, led by the University of Melbourne, have discovered a way to control the stem cell behaviour responsible for the spread of bowel cancer.
Jun 25, 2015
0
12
A*STAR researchers have shown that the RASAL2 gene, which is known to inhibit tumor growth in some breast cancers, actually advances tumor formation and metastasis in more aggressive forms of breast cancer and have suggested ...
May 27, 2015
0
16
