Scientists at The Wistar Institute discovered a novel pathway that enables detection of DNA in the cytoplasm and triggers inflammation and cellular senescence. This pathway may be modulated during senescence-inducing chemotherapy ...
Feb 19, 2020
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169
An international research team has succeeded in stopping the growth of malignant melanoma by reactivating a protective mechanism that prevents tumor cells from dividing. The team used chemical agents to block the enzymes ...
Feb 22, 2018
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273
Cells that become senescent irrevocably stop dividing under stress, spewing out a mix of inflammatory proteins that lead to chronic inflammation as more and more of the cells accumulate over time. Publishing in the September ...
Sep 24, 2019
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109
Glioblastomas are the most common malignant tumors of the adult brain. They resist conventional treatment, including surgery, followed by radiation therapy and chemotherapy. Despite this armamentarium, glioblastomas inexorably ...
Feb 21, 2023
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Intermittent dosing with rapamycin selectively breaks the cascade of inflammatory events that follow cellular senescence, a phenomena in which cells cease to divide in response to DNA damaging agents, including many chemotherapies. ...
Jul 6, 2015
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89
Inhibiting a key enzyme that controls a large network of proteins important in cell division and growth paves the way for a new class of drugs that could stop glioblastoma, a deadly brain cancer, from growing.
Feb 12, 2021
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113
Working with researchers from Stanford University and St. Anna Children's Cancer Research, researchers from Jürgen Pollheimer's laboratory at the Medical University of Vienna's Department of Obstetrics and Gynecology have ...
Oct 15, 2018
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88
In an unfinished part of his basement, 95-year-old Richard Soller zips around a makeshift track encircling boxes full of medals he's won for track and field and long-distance running.
Aug 31, 2022
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10
Buck Institute faculty Judith Campisi, PhD, says age researchers need to stop thinking of cellular senescence, now accepted as an important driver of aging, as a single phenotype that stems from genotoxic stress. Research ...
Dec 10, 2015
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145
For the first time, researchers have shown that an enzyme key to regulating gene expression—and also an oncogene when mutated—is critical for the expression of numerous inflammatory compounds that have been implicated ...
Feb 3, 2016
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