Alzheimer's disease & dementia

Ceramides predict vascular brain injury and dementia

Novel blood-based biomarkers for dementia could identify disease at an early preclinical stage, serve as surrogate outcomes for clinical trials of investigational therapies and even identify future potential therapeutic targets. ...

Diabetes

Tiny change has big effects, reverses prediabetes in mice

A small chemical change—shifting the position of two hydrogen atoms—makes the difference between mice that are healthy and mice with insulin resistance and fatty liver, major risk factors for diabetes and heart disease. ...

Diabetes

Improved diabetes in spite of obesity

Eating too much fat and sugar causes weight gain and reduced health. But why is that, and is there a remedy? In a study published in the journal Cell, Prof. Jens Brüning's research group at the Max Planck Institute for Metabolism ...

Parkinson's & Movement disorders

New evidence sheds light on how Parkinson's disease may happen

Researchers at Baylor College of Medicine and Texas Children's Hospital have identified unexpected new key players in the development of an early onset form of Parkinson's disease called Parkinsonism. These key players are ...

Cardiology

Controlling ceramides could help treat heart disease

Sanford Burnham Prebys Medical Discovery Institute (SBP) researchers have discovered that accumulation of a type of lipid (fat), known as ceramides, plays a crucial role in lipotoxic cardiomyopathy (LCM)—a heart condition ...

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