Losing the activity of a key ion channel in the brain may contribute to the buildup of a devastating and toxic protein responsible for the clumps of plaque that accumulate in Alzheimer's disease, a team of neurobiologists ...
Potential clues to how autism miswires the brain are emerging from a study of a rare, purely genetic form of the disorders that affects fewer than 20 people worldwide. Using cutting-edge "disease-in a-dish" technology, researchers ...
Nov 27, 2011
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A research team led by Prof. Dr. Hilmar Bading, neurobiologist at Heidelberg University, examined a neuroprotective molecule that belongs to a novel drug class. It is able to inhibit the interactions of certain proteins and ...
Feb 8, 2024
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The Noelin family of secreted proteins bind to the external portion of AMPA glutamate receptors and stabilize them on the neuronal cellular membrane, a process necessary for transmission of full-strength signals between neurons, ...
Aug 16, 2023
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The first mapping of the heart's crucial ion channels reveals a surprisingly extensive network of proteins. This understanding is the first step towards more precise treatment for patients with cardiac arrhythmias.
Aug 16, 2023
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A signaling protein known as STING is a critical player in the human immune system, detecting signs of danger within cells and then activating a variety of defense mechanisms.
Aug 3, 2023
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Early cognitive decline may result from a shift in the ratio of a protein sub-type in our brain cells triggering cell-loss. This new study, published in Scientific Reports, shows how this might be caused. The discovery provides ...
Oct 10, 2022
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Sometimes, even the alteration of a single nucleotide in a gene can cause serious disease. In a young boy with epilepsy, this kind of mutation has not just affected the functioning of the protein in question—it could also ...
May 23, 2022
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Dozens of commonly used drugs, including antibiotics, antinausea and anticancer medications, have a potential side effect of lengthening the electrical event that triggers contraction, creating an irregular heartbeat, or ...
May 14, 2021
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An unfortunate biological "feed-forward" loop drives cartilage cells in an arthritic joint to actually contribute to progression of the disease, say researchers at Duke University and Washington University in Saint Louis.
Mar 22, 2021
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