Chaperone protein imbalance can play a significant role in initiating toxic accumulation of tau in the aging brain—an early step in the development of Alzheimer's disease and related neurodegenerative disorders known as ...
Apr 20, 2021
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UNSW medical researcher Dr. David Jacques and his team have discovered how the human immunodeficiency virus (HIV) breaches the cell nucleus to establish infection, a finding that has implications beyond HIV biology.
Jan 24, 2024
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Scientists at the Max Planck Institute of Psychiatry in Munich have now identified a new functional link between the established depression risk factor FKBP51 and epigenetic changes. This new link improves our understanding ...
Nov 25, 2015
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Although the mutually beneficial relationship between human beings and gut microbes is clear, how we—the host—affect the functions of gut microbial communities remains poorly understood.
Aug 19, 2019
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Aging is the most significant and universal risk factor for developing neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and Alzheimer's, Parkinson's and Huntington's diseases. This risk increases disproportionately ...
Nov 3, 2014
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A study led by scientists at the Institute for Research in Biomedicine (IRB Barcelona) and published in Nature Communications proposes chaperone protein Hps70 as an attractive therapeutic target for the treatment of Kennedy's ...
Aug 8, 2019
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Targeting a single protein can help fight both breast cancers and leukemias, according to two reports published online on January 23 in the Journal of Experimental Medicine.
Jan 23, 2012
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Mutations in a gene involved in steroid signaling likely contribute to preterm birth, report Johanna Huusko of the University of Oulu and Cincinnati Children's Hospital Medical Center and colleagues, in a study of European ...
Jul 12, 2018
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Chaperone proteins play an important role in protein folding in human cells and in bacteria and are promising new targets for drugs to treat cancer and Alzheimer's disease and for novel antiviral drugs and antibiotics. How ...
Mar 9, 2015
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A drug that indirectly impairs the function of several cancer-driving proteins, including anaplastic lymphoma kinase (ALK), may be an effective new treatment for patients with ALK—positive non-small cell lung cancer.
Mar 26, 2013
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