Genetics

A protein essential for chikungunya virus replication identified

Originally from Africa, chikungunya is aptly named. It derives from a word in the Kimakonde language meaning "to become contorted," because the severe muscle and joint pains endured by the patients prevent them from moving ...

Diseases, Conditions, Syndromes

Study traces the origins of Chikungunya in Brazil

New evidence suggests that Chikungunya virus arrived in Brazil at least one year earlier than it was detected by public health surveillance systems. Scientists at the Center for Infection and Immunity (CII) at the Columbia ...

Diseases, Conditions, Syndromes

Toward vaccination against the chikungunya virus

A live vaccine genetically engineered from a common measles vaccine promises to be effective against the chikungunya virus. Such is the central finding of a recently completed Phase II trial now published in the prestigious ...

Diseases, Conditions, Syndromes

Why chikungunya, other arthritis-causing viruses target joints

Chikungunya virus is a growing threat to the United States and other regions of the world as the mosquito that carries the virus expands its reach. Telltale symptoms of chikungunya infection are fever and joint pain that ...

Diseases, Conditions, Syndromes

Infection mechanism of Rift Valley fever virus identified

Rift Valley fever virus, transmitted by mosquitoes, is responsible for outbreaks in livestock in Africa and can also be fatal in humans. Scientists from the Institut Pasteur and the CNRS, working with the University of Göttingen, ...

Diseases, Conditions, Syndromes

Drug combination effective against chikungunya arthritis in mice

Combining a drug for rheumatoid arthritis with one that targets the chikungunya virus can eliminate the signs of chikungunya arthritis in mice in the disease's earliest stage, according to researchers at Washington University ...

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Chikungunya

Chikungunya (in the Makonde language "that which bends up") virus (CHIKV) is an insect-borne virus, of the genus Alphavirus, that is transmitted to humans by virus-carrying Aedes mosquitoes. There have been recent breakouts of CHIKV associated with severe illness. CHIKV infection causes an illness with symptoms similar to dengue fever, with an acute febrile phase of the illness lasting only two to five days, followed by a prolonged arthralgic disease that affects the joints of the extremities. The pain associated with CHIKV infection of the joints persists for weeks or months, or in some cases years.

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