Cell differentiation is a widely studied phenomenon forming the basis of all developmental processes including fetal growth and bone fracture healing. A series of recent studies indicates the emerging role of chondrocyte-to-osteoblast ...
Articular cartilage is a connective tissue lining the surfaces of joints. When the cartilage severely wears down, it leads to osteoarthritis (OA), a debilitating disease that affects millions of people globally.
Jun 22, 2021
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An unfortunate biological "feed-forward" loop drives cartilage cells in an arthritic joint to actually contribute to progression of the disease, say researchers at Duke University and Washington University in Saint Louis.
Mar 22, 2021
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A disease of the joints, osteoarthritis affects more than 30 million adults and is the fifth-leading cause of disability in the United States. In a new study, scientists have discovered the cellular pathway that leads to ...
Feb 10, 2021
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In a paper published in the journal Nature, an international research team led by researchers at Karolinska Institutet in Sweden reports that bone growth in mice takes place in accordance with the same principles as when ...
Feb 27, 2019
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Our bones are smart. Bones know that by adolescence it's time to stop growing longer and stronger, and from that point on bones keep their shape by healing injuries.
Nov 24, 2014
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We live with the same cartilage—the tissue that connects our joints—for a lifetime. And since we can't readily make new cartilage cells, we had better figure out how to keep what we have healthy.
Nov 10, 2014
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(Medical Xpress)—Cartilage injuries are difficult to repair. Current surgical options generally involve taking a piece from another part of the injured joint and patching over the damaged area, but this approach involves ...
Jun 4, 2013
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A new research paper titled "Development of a DNA damage-induced senescence model in osteoarthritic chondrocytes" has been published in Aging.
Sep 20, 2023
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Growth plates (GP), situated at the ends of long bones in children, supply chondrocytes necessary for bone growth. Damage to the growth plate due to fractures often results in arrested bone growth, making it a significant ...
Jul 25, 2023
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