Oncology & Cancer

Study identifies link between DNA-protein binding, cancer onset

Researchers at the Stanford University School of Medicine and their collaborators at other institutions have identified a link between how proteins bind to our DNA and how cancer develops. This finding may allow researchers ...

Oncology & Cancer

A non-coding RNA lasso catches proteins in breast cancer cells

A Danish-German study reports new findings about long non-coding RNA expression in the development of cancer. The results have an impact on the understanding of dynamic regulation of gene expression in biological processes.

Neuroscience

Autism's social deficits are reversed by an anti-cancer drug

Of all the challenges that come with a diagnosis of autism spectrum disorder (ASD), the social difficulties are among the most devastating. Currently, there is no treatment for this primary symptom of ASD. New research at ...

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Chromatin

Chromatin is the combination of DNA and proteins that make up the contents of the nucleus of a cell. The primary functions of chromatin are; to package DNA into a smaller volume to fit in the cell, to strengthen the DNA to allow mitosis and meiosis and prevent DNA damage, and to control gene expression and DNA replication. The primary protein components of chromatin are histones that compact the DNA. Chromatin is only found in eukaryotic cells: prokaryotic cells have a very different organization of their DNA which is referred to as a genophore (a chromosome without chromatin).

The structure of chromatin depends on several factors. The overall structure depends on the stage of the cell cycle: during interphase the chromatin is structurally loose to allow access to RNA and DNA polymerases that transcribe and replicate the DNA. The local structure of chromatin during interphase depends on the genes present on the DNA: DNA coding genes that are actively transcribed ("turned on") are more loosely packaged and are found associated with RNA polymerases (referred to as euchromatin) while DNA coding inactive genes ("turned off") are found associated with structural proteins and are more tightly packaged (heterochromatin). Epigenetic chemical modification of the structural proteins in chromatin also alter the local chromatin structure, in particular chemical modifications of histone proteins by methylation and acetylation. As the cell prepares to divide, i.e. enters mitosis or meiosis, the chromatin packages more tightly to facilitate segregation of the chromosomes during anaphase. During this stage of the cell cycle this makes the individual chromosomes in many cells visible by optical microscope.

In general terms, there are three levels of chromatin organization:

There are, however, many of cells which do not follow this organisation. For example spermatozoa and avian red blood cells have more tightly packed chromatin than most eukaryotic cells and trypanosomatid protazoa do not condense their chromatin into visible chromosomes for mitosis.

This text uses material from Wikipedia, licensed under CC BY-SA