For more than 50 years, the conventional wisdom in the field of research in cocaine use has been that people take cocaine based on the theory of the drug providing positive reinforcement to the user.
Nov 15, 2023
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A study in Biological Psychiatry has identified unique genetic changes in the brain's reward circuitry that are associated with cocaine use, including first-time use, withdrawal, and re-exposure to the drug after prolonged ...
May 31, 2018
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The hypocretin/orexin (HCRT) system of the brain is best known for promoting wakefulness and appetite. A new paper in Biological Psychiatry suggests that blocking hypocretin signaling via the HCRT-1 receptor (HCRT-R1) might ...
Mar 16, 2017
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In the ongoing fight against drug addiction, researchers from the University of Pennsylvania's School of Nursing and Perelman School of Medicine have discovered a unique application for an FDA-approved drug currently used ...
Feb 10, 2016
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Yaoying Ma says that biology, by nature, has a yin and a yang—a push and a pull. Addiction, particularly relapse, she finds, is no exception.
Sep 4, 2014
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On the other side of the cocaine high is the cocaine crash, and understanding how one follows the other can provide insight into the physiological effects of drug abuse. For decades, brain research has focused on the pleasurable ...
Mar 5, 2014
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Research from the Perelman School of Medicine at the University of Pennsylvania and Massachusetts General Hospital (MGH) reveals that sons of male rats exposed to cocaine are resistant to the rewarding effects of the drug, ...
Dec 16, 2012
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