Psychology & Psychiatry

Women's hormones play role in drug addiction, higher relapse rates

Women's hormonal cycles may not only make them more prone to drug addiction but also more affected by triggers that lead to relapse, a new Vanderbilt University study revealed. The findings are especially significant since ...

Psychology & Psychiatry

Cocaine adulterant may cause brain damage

People who regularly take cocaine cut with the animal anti-worming agent levamisole demonstrate impaired cognitive performance and a thinned prefrontal cortex. These findings from two recent studies at the University of Zurich ...

Neuroscience

Resetting addicted brain: Laser light zaps away cocaine addiction

By stimulating one part of the brain with laser light, researchers at the National Institutes of Health (NIH) and the Ernest Gallo Clinic and Research Center at UC San Francisco (UCSF) have shown that they can wipe away addictive ...

Neuroscience

Researchers identify protein involved in cocaine addiction

Mount Sinai researchers have identified a protein produced by the immune system—granulocyte-colony stimulating factor (G-CSF)—that could be responsible for the development of cocaine addiction.

Neuroscience

Long-term cocaine addiction therapy developed

(MedicalXpress)—A team of researchers with the University of Kentucky has developed a long-term chemical treatment option for cocaine addiction. In their paper published in Proceedings of the National Academy of Sciences, ...

Neuroscience

Cocaine relapse is reversed with BDNF microinjections in the brain

Cocaine relapse was significantly reduced in a preclinical model when brain-derived neurotropic factor (BDNF) was applied to the nucleus accumbens deep in the brain immediately before cocaine-seeking behavior, report investigators ...

Medical research

Morphine and cocaine affect reward sensation differently

(Medical Xpress)—A new study by scientists in the US has found that the opiate morphine and the stimulant cocaine act on the reward centers in the brain in different ways, contradicting previous theories that these types ...

Neuroscience

Study in mice links cocaine use to new brain structures

Mice given cocaine showed rapid growth in new brain structures associated with learning and memory, according to a research team from the Ernest Gallo Clinic and Research Center at UC San Francisco. The findings suggest a ...

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Cocaine

Cocaine (benzoylmethylecgonine) is a crystalline tropane alkaloid that is obtained from the leaves of the coca plant. The name comes from "coca" in addition to the alkaloid suffix -ine, forming cocaine. It is both a stimulant of the central nervous system and an appetite suppressant. Specifically, it is a dopamine reuptake inhibitor, a norepinephrine reuptake inhibitor and a serotonin reuptake inhibitor, which mediates functionality of such as an exogenous DAT ligand. Because of the way it affects the mesolimbic reward pathway, cocaine is addictive.

Its possession, cultivation, and distribution are illegal for non-medicinal and non-government sanctioned purposes in virtually all parts of the world. Although its free commercialization is illegal and has been severely penalized in virtually all countries, its use worldwide remains widespread in many social, cultural, and personal settings.

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