Past research findings suggest that women who are addicted to cocaine are more sensitive to cocaine-related stimuli that make them crave the drug and relapse into addiction. However, other studies suggest that steroid hormones ...
Drug addiction is characterized by compulsive drug use among individuals despite adverse consequences underlying such tendencies. However, the specific neural circuits underlying the mechanisms of addictive behavior remain ...
(Medical Xpress)—A team of researchers working at Columbia University has found a possible link between prior use of alcohol and an increased risk of cocaine addiction. In their paper published on the open access site Science ...
(Medical Xpress)—A team of researchers with Fudan University in China has found that male rats are able to pass on their susceptibility to cocaine addiction through non-genetic means. In their paper published in the journal ...
Working with mice, researchers at Johns Hopkins have contributed significant new evidence to support the idea that high doses of cocaine kill brain cells by triggering overactive autophagy, a process in which cells literally ...
Jan 18, 2016
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Researchers from the Icahn School of Medicine at Mount Sinai have identified a new molecular mechanism by which cocaine alters the brain's reward circuits and causes addiction. Published online in the journal Proceedings ...
Jan 20, 2014
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Mice given cocaine showed rapid growth in new brain structures associated with learning and memory, according to a research team from the Ernest Gallo Clinic and Research Center at UC San Francisco. The findings suggest a ...
Aug 25, 2013
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By stimulating one part of the brain with laser light, researchers at the National Institutes of Health (NIH) and the Ernest Gallo Clinic and Research Center at UC San Francisco (UCSF) have shown that they can wipe away addictive ...
Apr 3, 2013
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Research from the Perelman School of Medicine at the University of Pennsylvania and Massachusetts General Hospital (MGH) reveals that sons of male rats exposed to cocaine are resistant to the rewarding effects of the drug, ...
Dec 16, 2012
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(Medical Xpress)—A new study by scientists in the US has found that the opiate morphine and the stimulant cocaine act on the reward centers in the brain in different ways, contradicting previous theories that these types ...
Cocaine (benzoylmethylecgonine) is a crystalline tropane alkaloid that is obtained from the leaves of the coca plant. The name comes from "coca" in addition to the alkaloid suffix -ine, forming cocaine. It is both a stimulant of the central nervous system and an appetite suppressant. Specifically, it is a dopamine reuptake inhibitor, a norepinephrine reuptake inhibitor and a serotonin reuptake inhibitor, which mediates functionality of such as an exogenous DAT ligand. Because of the way it affects the mesolimbic reward pathway, cocaine is addictive.
Its possession, cultivation, and distribution are illegal for non-medicinal and non-government sanctioned purposes in virtually all parts of the world. Although its free commercialization is illegal and has been severely penalized in virtually all countries, its use worldwide remains widespread in many social, cultural, and personal settings.
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