Cardiology

Lipo-protein apheresis and PCSK9-inhibitors

Research suggests a specific treatment for Homozygous Familial Hypercholesterolaemic (HoFH) pateints; a combination therapy with PCSK9-inhibitors (PCSK9-I) and lipoprotein-apheresis (LA) may have synergistic effects on circulating ...

Diseases, Conditions, Syndromes

Buruli ulcer: Promising new drug candidate against a forgotten disease

Buruli ulcer, a neglected tropical disease, is debilitating and stigmatising. Affecting mainly children in West and Central Africa, the chronic disease results in devastating skin lesions and can lead to permanent disfigurement ...

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Combination therapy

In contemporary usage, the expression combination therapy most often refers to the simultaneous administration of two or more medications to treat a single disease, but the expression is also used when other types of therapy are used at the same time.

Conditions treated with combination therapy include tuberculosis, leprosy, cancer, malaria, and HIV/AIDS.

Combination therapy may seem costlier than monotherapy in the short term but causes significant savings: lower treatment failure rate, lower case-fatality ratios, slower development of resistance and consequently, less money needed for the development of new drugs.

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