Medical research

Researchers solve structure of immune-evading HIV protein complex

The HIV-1 virus can neutralize cellular defenses with its viral infectivity factor (Vif). OIST researchers Prof. Matthias Wolf and Dr. Takahide Kouno together with an international team of colleagues have now determined the ...

Neuroscience

How a highly unstable protein may lead to neurodegeneration

EPFL scientists have reproduced key features of pathological protein aggregates found in the brain of patients with Lou Gehrig's disease and other neurological diseases, providing insight into the underlying mechanism and ...

Oncology & Cancer

Structural insights reveal how SPOP protein contributes to cancer

SPOP is the most mutated protein in prostate cancer and plays a role in endometrial, uterine and other cancers. Despite this importance, how SPOP mutations drive cancer has been incompletely understood. Scientists at St. ...

Diseases, Conditions, Syndromes

Researchers discover 'weak spot' across major COVID-19 variants

Researchers at the University of British Columbia have discovered a key vulnerability across all major variants of the SARS-CoV-2 virus, including the recently emerged BA.1 and BA.2 Omicron subvariants.

Neuroscience

Functioning of antibodies in autoimmune encephalitis deciphered

Using a state-of-the-art method, researchers at DZNE and the University of Texas have succeeded for the first time at unraveling the effects of autoimmune antibodies that are directed against the brain in detail at the atomic ...

Diseases, Conditions, Syndromes

Scientists reveal how 35B5 antibody neutralizes SARS-CoV-2 Omicron

Since November 2021, the SARS-CoV-2 Omicron has spread expeditiously all over the world and gradually superseded the previous attention-capturing the SARS-CoV-2 variants of concern (VOCs). The Omicron variant harbors more ...

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