Medical research

Changing the perspective on the 'Cinderella of the cytoskeleton'

SETD2 is a protein well known as a chromatin remodeler, one that helps turn genes on or off by modifying histone proteins in the nucleus of the cell. When researchers discovered that SETD2 is mutated or lost in several cancer ...

Genetics

A deeper connection to Hyaline Fibromatosis Syndrome

Hyaline Fibromatosis Syndrome (HFS) is a rare but severe genetic disease that affects babies, children, and adults. Hyaline, a glassy substance, accumulates in the skin and various organs, and causes painful deformities that ...

Oncology & Cancer

Form drives function in cancer proliferation

A new study finds that the protein responsible for the crawling movements of cells also drives the ability of cancer cells to grow when under stress.

Alzheimer's disease & dementia

Neuronal cytoskeletons involved in Alzheimer's disease

A researcher at the UPV/EHU participated in a study describing the loss of dynamics and subsequent impairment of the dendritic spines in Alzheimer's disease. Dendritic spines are the compartments of neurons responsible for ...

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Cytoskeleton

The cytoskeleton (also CSK) is a cellular "scaffolding" or "skeleton" contained within a cell's cytoplasm and is made out of protein. The cytoskeleton is present in all cells; it was once thought to be unique to eukaryotes, but recent research has identified the prokaryotic cytoskeleton. It has structures such as flagella, cilia and lamellipodia and plays important roles in both intracellular transport (the movement of vesicles and organelles, for example) and cellular division. In 1903 Nikolai K Koltsov proposed that the shape of cells was determined by a network of tubules which he termed the cytoskeleton. The concept of a protein mosaic that dynamically coordinated cytoplasmic biochemistry was proposed by Rudolph Peters in 1929 while the term (cytosquelette, in French) was first introduced by French embryologist Paul Wintrebert in 1931.

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