Medical research

Scientists discover potential cause of Alzheimer's disease

Prevailing theories posit plaques in the brain cause Alzheimer's disease. New UC Riverside research instead points to cells' slowing ability to clean themselves as the likely cause of unhealthy brain buildup.

Alzheimer's disease & dementia

LATE: A common but largely unknown cause of dementia

If dementia is a general term that means thinking and memory has deteriorated to the point that it interferes with day-to-day function, what are the top three disorders that cause dementia in older individuals?

Alzheimer's disease & dementia

Metformin treatment linked to slowed cognitive decline

Metformin is the first-line treatment for most cases of type 2 diabetes and one of the most commonly prescribed medications worldwide, with millions of individuals using it to optimize their blood glucose levels.

Neuroscience

Brain benefits of exercise can be gained with a single protein

A little-studied liver protein may be responsible for the well-known benefits of exercise on the aging brain, according to a new study in mice by scientists in the UC San Francisco Eli and Edythe Broad Center for Regeneration ...

Alzheimer's disease & dementia

Improving deep sleep may prevent dementia, study finds

As little as 1% reduction in deep sleep per year for people over 60 years of age translates into a 27% increased risk of dementia, according to a study which suggests that enhancing or maintaining deep sleep, also known as ...

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Dementia

Dementia (meaning "deprived of mind") is a cognitive impairment. It may be static, the result of a unique global brain injury or progressive, resulting in long-term decline in cognitive function due to damage or disease in the body beyond what might be expected from normal aging. Although dementia is far more common in the geriatric population, it may occur in any stage of adulthood. This age cutoff is defining, as similar sets of symptoms due to organic brain syndrome or dysfunction, are given different names in populations younger than adult. Up to the end of the nineteenth century, dementia was a much broader clinical concept.

Dementia is a non-specific illness syndrome (set of signs and symptoms) in which affected areas of cognition may be memory, attention, language, and problem solving. It is normally required to be present for at least 6 months to be diagnosed; cognitive dysfunction which has been seen only over shorter times, particularly less than weeks, must be termed delirium. In all types of general cognitive dysfunction, higher mental functions are affected first in the process. Especially in the later stages of the condition, affected persons may be disoriented in time (not knowing what day of the week, day of the month, or even what year it is), in place (not knowing where they are), and in person (not knowing who they are or others around them). Dementia, though often treatable to some degree, is usually due to causes which are progressive and incurable.

Symptoms of dementia can be classified as either reversible or irreversible, depending upon the etiology of the disease. Less than 10 percent of cases of dementia are due to causes which may presently be reversed with treatment. Causes include many different specific disease processes, in the same way that symptoms of organ dysfunction such as shortness of breath, jaundice, or pain are attributable to many etiologies. Without careful assessment of history, the short-term syndrome of delirium (often lasting days to weeks) can easily be confused with dementia, because they have all symptoms in common, save duration, and the fact that delirium is often associated with over-activity of the sympathetic nervous system. Some mental illnesses, including depression and psychosis, may also produce symptoms which must be differentiated from both delirium and dementia.

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