Health

Immune study sheds light on vitamin D effects

Scientists have uncovered fresh insights into how vitamin D affects the immune system and might influence susceptibility to diseases such as multiple sclerosis.

Immunology

Immunotherapy kicks and kills HIV by exploiting a common virus

In a first on the quest to cure HIV, University of Pittsburgh Graduate School of Public Health scientists report today in EBioMedicine that they've developed an all-in-one immunotherapy approach that not only kicks HIV out ...

Cancer

Nullifying protein YTHDF1 enhances anti-tumor response

Cancer immunotherapy—an approach that removes the barriers that protect cancer cells from a patient's immune system—has revolutionized the treatment of many cancer types. About 40 percent of melanoma patients, for example, ...

Alzheimer's disease & dementia

Neuronal cytoskeletons involved in Alzheimer's disease

A researcher at the UPV/EHU participated in a study describing the loss of dynamics and subsequent impairment of the dendritic spines in Alzheimer's disease. Dendritic spines are the compartments of neurons responsible for ...

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Dendrite

Dendrites (from Greek δένδρον déndron, “tree”) are the branched projections of a neuron that act to conduct the electrochemical stimulation received from other neural cells to the cell body, or soma, of the neuron from which the dendrites project. Electrical stimulation is transmitted onto dendrites by upstream neurons via synapses which are located at various points throughout the dendritic arbor. Dendrites play a critical role in integrating these synaptic inputs and in determining the extent to which action potentials are produced by the neuron. Recent research has also found that dendrites can support action potentials and release neurotransmitters, a property that was originally believed to be specific to axons.

The long outgrowths on immune system dendritic cells are also called dendrites. These dendrites do not process electrical signals.

Certain classes of dendrites (i.e. Purkinje cells of cerebellum, cerebral cortex) contain small projections referred to as "appendages" or "spines". Appendages increase receptive properties of dendrites to isolate signal specificity. Increased neural activity at spines increases their size and conduction which is thought to play a role in learning and memory formation. There are approximately 200,000 spines per cell, each of which serve as a postsynaptic process for individual presynaptic axons.

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