Medical research

Like patching a flat tire: New fix heals herniated discs

A new two-step technique to repair herniated discs uses hyaluronic acid gel to re-inflate the disc and collagen gel to seal the hole, essentially repairing ruptured discs like you'd repair a flat tire.

Surgery

Best treatment for herniated disc

Sudden back pain is often caused by a herniated disc. The intervertebral discs are a kind of buffer between the vertebrae and are heavily strained over the years. If they become brittle and break, parts of the tissue can ...

Medications

Opioid crisis brings concerns about heart dangers

Dan Willard doesn't remember a thing from those fateful 48 hours. Not what happened to the 32 pills of prescribed painkiller—nor how his daughter dragged his body from the chair to the floor so she could follow the emergency ...

Diseases, Conditions, Syndromes

Genetic studies and MRI scans shed light on low back pain

By delving into the mysteries of low back pain, scientists have identified three genes linked to chronic back pain and proposed the order in which pathological changes to the spine lead to low back pain.

page 1 from 13

DLG4

PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the DLG4 (disks large homolog 4) gene.

PSD-95 is a member of the membrane-associated guanylate kinase (MAGUK) family. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins.

PSD-95 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin, NMDA receptors, AMPA receptors, and potassium channels.

This text uses material from Wikipedia, licensed under CC BY-SA