Last week in a post on X, owner of the platform Elon Musk recommended people look into disk replacement if they're experiencing severe neck or back pain.
13 hours ago
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Type 2 diabetes alters the behavior of disks in the vertebral column, making them stiffer, and also causes the disks to change shape earlier than normal. As a result, the disk's ability to withstand pressure is compromised. ...
Feb 13, 2024
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Consistent daily patterns of exercise and rest can synchronize the local body clocks associated with joints and spine with the brain clock, potentially helping individuals to maintain skeletal health, improve athletic performance ...
Nov 14, 2023
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If you haven't had lower back pain, it's likely you know someone who has. It affects around 40% of adults in any year, ranging from adolescents to those in later life. While most people recover, around 20% go on to develop ...
Sep 9, 2023
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The phrase "pain in the neck" is a tongue-in-cheek way to describe annoying situations or people that test our patience, but for those who experience genuine neck pain, it's no laughing matter.
Jun 21, 2023
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Imagine a life where even the simplest movement becomes a painful endeavor.
Jun 21, 2023
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The leading cause of vision loss in Western countries is age-related macular degeneration (AMD), a deterioration of central vision that begins when droplets of lipids and proteins called lipofuscin accumulate in the retina ...
May 11, 2023
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It's a familiar story: you feel a twinge in your back and next thing you know, you can't get out of bed. From back pain to achy joints, musculoskeletal pain, while common, can be life-changing and debilitating. But does it ...
Mar 2, 2023
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A minimally invasive treatment that injects allograft disk tissue into the spine to relieve pain associated with degenerative disk disease provides significant improvement in pain and function over a sustained period, according ...
Mar 1, 2023
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A recent study from University Hospitals (UH) Connor Whole Health has found that adults who initially visit a chiropractor to receive spinal manipulation for low back pain caused by disc herniation or radiculopathy (i.e., ...
Dec 19, 2022
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PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the DLG4 (disks large homolog 4) gene.
PSD-95 is a member of the membrane-associated guanylate kinase (MAGUK) family. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins.
PSD-95 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin, NMDA receptors, AMPA receptors, and potassium channels.
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