Diabetes

A better diagnosis of rare diabetes to adapt treatment

Diabetes affects more than 400 million people worldwide and is a major public health problem. Although commonly referred to as a single disease, it actually constitutes a group of metabolic disorders with hyperglycaemia as ...

Dentistry

Study reveals how too much fluoride causes defects in tooth enamel

Exposing teeth to excessive fluoride alters calcium signaling, mitochondrial function, and gene expression in the cells forming tooth enamel—a novel explanation for how dental fluorosis, a condition caused by overexposure ...

Genetics

Gene therapy can protect against ALS and SMA-related cell death

Researchers at Karolinska Institutet in Sweden and the University of Milan in Italy have identified a gene in human neurons that protects against the degeneration of motor neurons in the deadly diseases ALS and SMA. Gene ...

Genetics

CRISPR 'minigene' approach stops genetic liver disease in mice

A new CRISPR gene-editing technique prevented a genetic liver disease known to be driven by hundreds of different mutations and improved clinical symptoms in mice, Penn Medicine researchers reported in new proof-of-concept ...

Medical research

Fat droplets play surprise role in metabolism

In suspense novels, the most unassuming character sometimes turns out to be a mastermind, influencing events without attracting attention. That same storyline may be afoot in cells as well: an unglamorous fat-storing droplet ...

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