Researchers identify abrupt epigenetic aging of the colon
DNA methylation data provide extremely accurate age predictors, but so far, little is known about the dynamics of this epigenomic biomarker over the course of life.
Apr 22, 2024
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DNA methylation data provide extremely accurate age predictors, but so far, little is known about the dynamics of this epigenomic biomarker over the course of life.
Apr 22, 2024
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A study has revealed how aberrant epigenetic regulation contributes to the development of atypical teratoid/rhabdoid (AT/RT) tumors, which are aggressive brain tumors that mainly affect young children. There is an urgent ...
Apr 15, 2024
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Mutations are the changes in the DNA that gradually occur in human cells as they replicate, and the organism grows and ages. Some of these changes, particularly when they occur in genes, can be instrumental during the development ...
Apr 10, 2024
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Many psychiatric illnesses are related to stress. Negative experiences in childhood can often affect how we deal with stress later in life. But what biological processes are involved? A study recently published in the journal ...
Apr 9, 2024
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Pregnancy may carry a cost, reports a new study from the Columbia University Mailman School of Public Health. The research, carried out among 1,735 young people in the Philippines, shows that women who reported having been ...
Apr 8, 2024
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The central dogma proposed that genetic information predominantly transfers from DNA to RNA during gene expression to make a functional product protein. This absolute theory has been debunked because of the influence of the ...
Mar 25, 2024
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E-cigarette users with a limited smoking history experience similar DNA changes to specific cheek cells as smokers, finds a new study led by researchers at UCL (University College London) and University of Innsbruck.
Mar 19, 2024
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Researchers have identified several differences in DNA methylation in people who experienced preeclampsia during pregnancy, according to a new study from Oregon Health & Science University. The study also revealed these differences ...
Mar 14, 2024
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It's no secret that smoking is extremely detrimental to health. Tobacco smoke contains thousands of chemicals, including carcinogens, increasing the risk of cancer, cardiovascular and respiratory diseases.
Mar 14, 2024
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A new research paper titled "Associations of prenatal one-carbon metabolism nutrients and metals with epigenetic aging biomarkers at birth and in childhood in a US cohort" has been published in Aging.
Mar 12, 2024
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DNA methylation is a type of chemical modification of DNA that can be inherited and subsequently removed without changing the original DNA sequence. As such, it is part of the epigenetic code and is also the best characterized epigenetic mechanism. Because methylation is a common capability of all viruses for self non-self identification, the epigenetic code could be a persistent remnant of ancient viral infection events.
DNA methylation involves the addition of a methyl group to DNA — for example, to the number 5 carbon of the cytosine pyrimidine ring — in this case with the specific effect of reducing gene expression. DNA methylation at the 5 position of cytosine has been found in every vertebrate examined. In adult somatic tissues, DNA methylation typically occurs in a CpG dinucleotide context; non-CpG methylation is prevalent in embryonic stem cells.
In plants, cytosines are methylated both symmetrically (CpG or CpNpG) and asymmetrically (CpNpNp), where N can be any nucleotide but guanine.
Research has suggested that long term memory storage in humans may be regulated by DNA methylation.
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