Genetics

Study finds crucial step in DNA repair

Scientists at Washington State University have identified a crucial step in DNA repair that could lead to targeted gene therapy for hereditary diseases such as "children of the moon" and a common form of colon cancer.

Oncology & Cancer

New cancer algorithm flags genetic weaknesses in tumors

A new way to identify tumors that could be sensitive to particular immunotherapies has been developed using data from thousands of NHS cancer patient samples sequenced through the 100,000 Genomes Project. The MMRDetect clinical ...

Neuroscience

Study finds that aging neurons accumulate DNA damage

MIT neuroscientists have discovered that an enzyme called HDAC1 is critical for repairing age-related DNA damage to genes involved in memory and other cognitive functions. This enzyme is often diminished in both Alzheimer's ...

Medications

Potential drug targets for ALS and FTD identified in two studies

A pair of collaborative studies led by Fen-Biao Gao, Ph.D., have identified two potential drug targets for the diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The studies, which appear in Nature ...

Oncology & Cancer

New role for a driver of metastatic cancers

Metastatic ovarian, prostate and breast cancers are notoriously difficult to treat and often deadly. Now, Salk Institute researchers have revealed a new role for the CDK12 protein. The findings were published in the print ...

Genetics

More than just a DNA repair deficiency syndrome

Cockayne syndrome is a rare hereditary disease that can lead to dwarfism, neurological impairment, premature aging and a shortened life span. Skin symptoms include a striking sensitivity to UV rays and a dramatic loss of ...

Oncology & Cancer

Key cancer-fighting gene's secret weapons revealed

The findings revealed that a special group of genes that function within the body's normal DNA repair process were vital to the effectiveness of p53. This new information could help doctors to better identify patients with ...

page 1 from 10